Results 31 to 40 of about 9,649,206 (293)
Neuroscience Insights, 2019 Recombinant adeno-associated virus (rAAV) vectors have emerged as the safe vehicles of choice for long-term gene transfer in mammalian nervous system. Recombinant adeno-associated virus–mediated localized gene transfer in adult nervous system following ...
Asad Jan +4 more
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A simplified purification protocol for recombinant adeno-associated virus vectors
Molecular Therapy: Methods & Clinical Development, 2014 We describe a new rapid, low cost, and scalable method for purification of various recombinant adeno-associated viruses (rAAVs) from the lysates of producer cells of either mammalian or insect origin. The method takes advantage of two general biochemical
Mark Potter +10 more
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Thermostability and in vivo performance of AAV9 in a film matrix
Communications Medicine, 2022 Doan et al. characterize and assess the stability of film matrix embedded Adeno-Associated Virus 9 (AAV9) vectors during storage and transport at ambient temperatures.
Trang Nguyen Kieu Doan +10 more
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Receptor targeting of adeno-associated virus vectors [PDF]
Gene Therapy, 2003 Adeno-associated virus (AAV) is a promising vector for human somatic gene therapy. However, its broad host range is a disadvantage for in vivo gene therapy, because it does not allow the selective tissue- or organ-restricted transduction required to enhance the safety and efficiency of the gene transfer.
H, Büning +6 more
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Generation of enhanced gene delivery vectors by directed evolution of adeno-associated virus [PDF]
, 2006 Despite promising advance in the development of viral vectors based on AAV for human gene therapy, several major hurdles for a more general use remain.
Endell, Jan
core +1 more source
Scientific Reports, 2021 Available therapeutics for autoimmune disorders focused on mitigating symptoms, rather than treating the cause of the disorder. A novel approach using adeno-associated virus (AAV) could restore tolerance to the autoimmune targets and provide a permanent ...
Matthew Wade +3 more
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Adeno-associated virus integration: virus versus vector [PDF]
Gene Therapy, 2008 Although a large percentage of the world population is seropositive for exposure to various strains of adeno-associated virus (AAV), a human parvovirus, AAV has never been identified as an etiologic agent of human disease. Most likely contributing to the pronounced lack of pathogenicity is the fact that AAV is a naturally defective virus that requires ...
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Adeno-associated virus vector integration junctions [PDF]
Journal of Virology, 1997 Vectors derived from adeno-associated virus (AAV) have the potential to stably transduce mammalian cells by integrating into host chromosomes. Despite active research on the use of AAV vectors for gene therapy, the structure of integrated vector proviruses has not previously been analyzed at the DNA sequence level.
E A, Rutledge, D W, Russell
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Adeno‐associated virus vectors for gene therapy—focusing on melanoma
Interdisciplinary MedicineAdeno‐Associated Virus (AAV) vectors have been found to have great potential in the field of gene therapy due to their unique properties. These nonpathogenic vectors exhibit high tissue specificity, low immunogenicity, and sustained gene expression ...
Xingyue Wang +6 more
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Nature Communications, 2020 Adeno-associated virus is the basis of many gene therapies and gene transfer vectors. Here the authors report a pipeline to enable side-by-side comparison of pre-selected capsids in a high throughput manner.
Jonas Weinmann +17 more
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