Results 171 to 180 of about 57,312 (301)

Metformin as a Multifaceted Therapeutic Agent for Gastrointestinal Diseases: Mechanisms, Clinical Efficacy, and Future Directions

open access: yesPharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.
ABSTRACT The high prevalence of gastrointestinal (GI) diseases and their significant impact on the quality of life require new therapeutic strategies. The development of novel therapeutic strategies should prioritize targeting the fundamental pathophysiological mechanisms underlying these diseases, including inflammation, cellular proliferation, and ...
Sayedeh Azimeh Hosseini   +7 more
wiley   +1 more source

Aquaporin‐1 differentiates intrahepatic cholangiocarcinoma from liver metastases of pancreatic ductal adenocarcinoma

open access: yesHistopathology, Volume 88, Issue 7, Page 1360-1372, June 2026.
Differentiating intrahepatic CCA from PDAC metastatic to the liver is critical for the clinical management of patients with pancreatobiliary cancers. AQP1 has demonstrated an excellent discriminatory performance in this clinical scenario. Aims Differentiating intrahepatic cholangiocarcinoma (iCCA) from metastatic ductal adenocarcinoma of the pancreas ...
Leoncini Giuseppe   +7 more
wiley   +1 more source

Changes in the 6th edition of the World Health Organization classification of tumours of the digestive system

open access: yesHistopathology, Volume 88, Issue 7, Page 1295-1314, June 2026.
Changes and new entities in the 6th edition WCT of the digestive system, including structural, molecular, and diagnostic updates to standardize terminology and improve clinical relevance. Epithelial tumours are organized by site; neuroendocrine, mesenchymal and haematolymphoid tumours have dedicated chapters, with refined grading, redefined ...
Mark J Arends   +48 more
wiley   +1 more source

Human papillomavirus‐associated adenoma of the anorectum

open access: yesHistopathology, Volume 88, Issue 7, Page 1459-1463, June 2026.
Aims Human papillomavirus (HPV) is the most common sexually transmitted disease in the United States. HPV‐associated invasive anorectal adenocarcinoma has been previously described. In this study, we report the clinicopathological features of three HPV‐associated anorectal adenomas.
Paula Toro   +3 more
wiley   +1 more source

Home - About - Disclaimer - Privacy