Results 111 to 120 of about 823,307 (385)

MicroRNA expression profiles associated with prognosis and therapeutic outcome in colon adenocarcinoma.

Journal of the American Medical Association (JAMA), 2008
CONTEXT MicroRNAs have potential as diagnostic biomarkers and therapeutic targets in cancer. No study has evaluated the association between microRNA expression patterns and colon cancer prognosis or therapeutic outcome.
Aaron J. Schetter, S. Leung, Jane J. Sohn, Krista A. Zanetti, E. Bowman, N. Yanaihara, S. Yuen, T. Chan, D. Kwong, G. Au, Chang-gong Liu, G. Calin, C. Croce, C. Harris   +13 more
semanticscholar   +1 more source

Adenosine A3 receptor antagonists as anti‐tumor treatment in human prostate cancer: an in vitro study

FEBS Open Bio, EarlyView.
The A3 adenosine receptors (A3ARs) are overexpressed in prostate cancer. AR 292 and AR 357, as A3AR antagonists, are capable of blocking proliferation, modulating the expression of drug transporter genes involved in chemoresistance, ferroptosis, and the hypoxia response, and inducing cell death.
Maria Beatrice Morelli, Andrea Spinaci, Cui Chang, Rosaria Volpini, Catia Lambertucci, Matteo Landriscina, Vincenza Conteduca, Consuelo Amantini, Cristina Aguzzi, Laura Zeppa, Martina Giangrossi, Laura Soverchia, Matteo Santoni, Massimo Nabissi, Giorgio Santoni, Carlo Polidori   +15 more
wiley   +1 more source

BRCA2‐positive lung adenocarcinoma treated with olaparib: A case report

Respirology Case Reports
A 66‐year‐old woman was found to have abnormal shadows on a chest radiograph at a previous hospital 4 years ago, which led to a diagnosis of lung adenocarcinoma, cT2aN1M1b stage IVA.
Takumi Motohashi, Kazutoshi Isobe, Takahiro Yoshizawa, Yusuke Usui, Hiroshige Shimizu, Muneyuki Sekiya, Shion Miyoshi, Yasuhiko Nakamura, Naohisa Urabe, Susumu Sakamoto, Sakae Homma, Sota Sadamoto, Naobumi Tochigi, Kazuma Kishi   +13 more
doaj   +1 more source

Detecting Pancreatic Ductal Adenocarcinoma in Multi-phase CT Scans via Alignment Ensemble [PDF]

arXiv, 2020
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers among the population. Screening for PDACs in dynamic contrast-enhanced CT is beneficial for early diagnosis. In this paper, we investigate the problem of automated detecting PDACs in multi-phase (arterial and venous) CT scans.
arxiv  

Possible role of human ribonuclease dicer in the regulation of R loops

FEBS Open Bio, EarlyView.
R loops play an important role in regulating key cellular processes such as replication, transcription, centromere stabilization, or control of telomere length. However, the unscheduled accumulation of R loops can cause many diseases, including cancer, and neurodegenerative or inflammatory disorders. Interestingly, accumulating data indicate a possible
Klaudia Wojcik, Paulina Krzeminska, Anna Kurzynska‐Kokorniak   +2 more
wiley   +1 more source

A solitary rod‐shaped intertrabecular metastasis in the femur

Respirology Case Reports
Key message Intertrabecular metastasis (ITM) is a type of bone metastasis characterized by tumour growth without significant trabecular changes. ITM is most commonly found in vertebral bodies, and rarely in long bones. We report a solitary rod‐shaped ITM
Mako Yokoyama, Toshihide Inui, Tomohiro Namiki, Hiroaki Ishikawa, Hiroko Watanabe, Yuichi Dai, Tohru Sakamoto   +6 more
doaj   +1 more source

Downregulation of O‐GlcNAcylation enhances etoposide‐induced p53‐mediated apoptosis in HepG2 human liver cancer cells

FEBS Open Bio, EarlyView.
Etoposide, a topoisomerase II inhibitor, reduces O‐GlcNAcylation in HepG2 liver cancer cells. Further inhibition of O‐GlcNAc transferase by OSMI‐1 enhanced etoposide‐induced apoptosis, lowering the IC50 for viability and increasing the EC50 for cytotoxicity.
Jaehoon Lee, Gi‐Bang Koo, Jihye Park, Byung‐Cheol Han, Mijin Kwon, Seung‐Ho Lee   +5 more
wiley   +1 more source

Long non‐coding RNAs as therapeutic targets in head and neck squamous cell carcinoma and clinical application

FEBS Open Bio, EarlyView.
Long non‐coding RNAs (lncRNAs) occupy an abundant fraction of the eukaryotic transcriptome and an emerging area in cancer research. Regulation by lncRNAs is based on their subcellular localization in HNSCC. This cartoon shows the various functions of lncRNAs in HNSCC discussed in this review.
Ellen T. Tran, Ruchi A. Patel, Amogh Chariyamane, Ratna B. Ray   +3 more
wiley   +1 more source

Understanding and Overcoming Immunotherapy Resistance in Skin Cancer: Mechanisms and Strategies

Aging and Cancer, EarlyView.
This narrative review explores the mechanisms driving immunotherapy resistance in skin cancer, including tumor microenvironment factors, genetic mutations, and immune evasion strategies. It highlights potential strategies to overcome resistance, offering insights for improving therapeutic outcomes and guiding future research in personalized ...
Shreya Singh Beniwal, Abhimanyu Chiraparambil Radhakrishnan, Ayanchetty Haripraba, Saif Syed, Gajawada Pragna, Ayush Dwivedi, Akash Rawat, Daniela Castro Calderón, Martin Cevallos‐Cueva   +8 more
wiley   +1 more source

T2‐weighted imaging of rectal cancer using a 3D fast spin echo sequence with and without deep learning reconstruction: A reader study

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Purpose To compare image quality and clinical utility of a T2‐weighted (T2W) 3‐dimensional (3D) fast spin echo (FSE) sequence using deep learning reconstruction (DLR) versus conventional reconstruction for rectal magnetic resonance imaging (MRI).
Dan Nguyen, Sarah Palmquist, Ken‐Pin Hwang, Jingfei Ma, Usama Salem, Jia Sun, Xinzeng Wang, Jong Bum Son, Randy Ernst, Peng Wei, Harmeet Kaur, Nir Stanietzky   +11 more
wiley   +1 more source