Results 181 to 190 of about 823,307 (385)
Somatic mutations affect key pathways in lung adenocarcinoma
Nature, 2008 L. Ding, G. Getz, D. Wheeler, E. Mardis, M. McLellan, K. Cibulskis, C. Sougnez, H. Greulich, D. Muzny, M. Morgan, L. Fulton, R. Fulton, Qunyuan Zhang, M. Wendl, M. Lawrence, D. Larson, Ken Chen, D. Dooling, A. Sabo, A. Hawes, Hua Shen, S. Jhangiani, L. Lewis, O. Hall, Yiming Zhu, T. Mathew, Yanru Ren, Jiqiang Yao, S. Scherer, Kerstin Clerc, G. Metcalf, Brian Y. Ng, A. Milosavljevic, M. Gonzalez-Garay, John R. Osborne, R. Meyer, Xiaoqi Shi, Yuzhu Tang, D. Koboldt, Ling Lin, R. Abbott, T. Miner, C. Pohl, Ginger A. Fewell, C. Haipek, Heather K. Schmidt, Brian H. Dunford-Shore, A. Kraja, S. Crosby, Christopher Sawyer, T. Vickery, Sacha N Sander, J. Robinson, W. Winckler, J. Baldwin, L. Chirieac, A. Dutt, T. Fennell, M. Hanna, B. Johnson, R. Onofrio, Roman K. Thomas, G. Tonon, B. Weir, Xiaojun Zhao, L. Ziaugra, M. Zody, T. Giordano, M. Orringer, J. Roth, M. Spitz, I. Wistuba, B. Ozenberger, P. Good, A. Chang, D. Beer, M. Watson, M. Ladanyi, S. Broderick, A. Yoshizawa, W. Travis, W. Pao, M. Province, G. Weinstock, H. Varmus, S. Gabriel, E. Lander, R. Gibbs, M. Meyerson, R. Wilson +89 moresemanticscholar +1 more sourceMetabolic‐Immune Suppression Mediated by the SIRT1‐CX3CL1 Axis Induces Functional Enhancement of Regulatory T Cells in Colorectal Carcinoma
Advanced Science, EarlyView.This study discovers that SIRT1, a hub gene involved in glucolipid metabolic conversion in colorectal carcinoma (CRC), stimulates CX3CL1 secretion in CRC cells by activating FOXO1. The CX3CL1‐CX3CR1 signaling promotes the differentiation of TCF7+ regulatory T cells (Tregs) into an enhanced immunosuppressive TNFRSF9+ Treg phenotype.Ruiyang Zi, Xiang Zhao, Limei Liu, Yijie Wang, Rui Zhang, Zhiheng Bian, Haoran Jiang, Taorui Liu, Yixin Sun, Han Peng, Xuesong Wang, Fanghao Lu, Chao Zhang, Fan Zhang, Qing Qin, Houjie Liang, Jianjun Li, Zhihao Wei, Yan Dong +18 morewiley +1 more sourceDeciphering the Transcription Factor Landscape in Prostate Cancer Progression: A Novel Approach to Understand NE Transdifferentiation
Advanced Science, EarlyView.The study deciphers the landscapes of lineage‐related transcription factors in prostatic adenocarcinoma and neuroendocrine prostate cancer using an innovative approach. These findings, validated across cohorts, highlight TFs' roles in cell development and offer novel therapeutic targets.Yu Wang, Hui Xue, Xiaohui Zhu, Dong Lin, Zheng Chen, Xin Dong, Junru Chen, Mingchen Shi, Yuchao Ni, Jonathan Cao, Rebecca Wu, Connie Kang, Xinyao Pang, Francesco Crea, Yen‐Yi Lin, Colin C. Collins, Martin E. Gleave, Abhijit Parolia, Arul Chinnaiyan, Christopher J. Ong, Yuzhuo Wang +20 morewiley +1 more sourceInhalable Hsa‐miR‐30a‐3p Liposomes Attenuate Pulmonary Fibrosis
Advanced Science, EarlyView.The study explores inhalable hsa‐miR‐30a‐3p‐loaded liposomes as a treatment for bleomycin‐induced pulmonary fibrosis in mice. Hsa‐miR‐30a‐3p is electroporated into liposomes and formulated into a dry powder for inhalation. Delivered via dry powder inhalation, it improves pulmonary function, promotes myofibroblast de‐differentiation by targeting CNPY2 ...Shuo Liu, Kristen D. Popowski, Christina M. Eckhardt, Weihang Zhang, Junlang Li, Yujia Jing, Dylan Silkstone, Elizabeth Belcher, Megan Cislo, Shiqi Hu, Halle Lutz, Asma Ghodsi, Mengrui Liu, Phuong‐Uyen C. Dinh, Ke Cheng +14 morewiley +1 more sourceStructural Insights into an Antiparallel Chair‐Type G‐Quadruplex From the Intron of NOP56 Oncogene
Advanced Science, EarlyView.This study first reports that the intron 1 of NOP56 oncogene forms an antiparallel chair‐type G4 structure composed of two G‐tetrads and one C∙G∙C∙G tetrad. NOP56 gene transcription can be inhibited by PDS that binds and stabilizes NOP56‐G4. Solution NMR structures of the free NOP56‐G4 and NOP56‐G4‐PDS complex provide valuable insights into G4 ...Zhenzhen Yan, Axin He, Liqi Wan, Qian Gao, Yan Jiang, Yang Wang, Ercheng Wang, Changling Li, Yingquan Yang, Yingjie Li, Pei Guo, Da Han +11 morewiley +1 more sourceTargeting KMT5C Suppresses Lung Cancer Progression and Enhances the Efficacy of Immunotherapy
Advanced Science, EarlyView.This study reveals that KMT5C activates DNA damage repair to inhibit STING‐IRF3 pathway, downstream type I IFN signaling and CCL5 secretion, leading to the downregulation of CD8+ T cell infiltration and function in NSCLC, ultimately facilitating tumor progression.Yunfeng Yuan, Qianyu Li, Guoquan Yan, Yifei Qian, Wenyun Guo, Songling Li, Fan Wang, Wanjing Shang, Zijun Zhu, Di Ge, Yanan Wang, Yanfeng Liu +11 morewiley +1 more sourceIntegrated Genomic Characterization of Pancreatic Ductal Adenocarcinoma.
Cancer Cell, 2017 Benjamin J. Raphael, R. Hruban, A. Aguirre, R. Moffitt, J. Yeh, C. Stewart, A. G. Robertson, A. Cherniack, M. Gupta, G. Getz, S. Gabriel, M. Meyerson, C. Cibulskis, S. Fei, T. Hinoue, Hui Shen, P. Laird, Shiyun Ling, Yiling Lu, G. Mills, Rehan Akbani, Phillipe Loher, Eric Londin, I. Rigoutsos, Aristeidis G. Telonis, E. Gibb, A. Goldenberg, A. Mezlini, K. Hoadley, E. Collisson, E. Lander, Bradley A. Murray, J. Hess, Mara W Rosenberg, Louis Bergelson, Hailei Zhang, Juok Cho, G. Tiao, Jaegil Kim, D. Livitz, I. Leshchiner, B. Reardon, E. Allen, A. Kamburov, R. Beroukhim, G. Saksena, S. Schumacher, M. Noble, David I Heiman, Nils Gehlenborg, M. Lawrence, V. Adsay, G. Petersen, D. Klimstra, N. Bardeesy, Mark D. M. Leiserson, R. Bowlby, K. Kasaian, I. Birol, K. Mungall, S. Sadeghi, J. Weinstein, P. Spellman, Yuexin Liu, L. Amundadottir, J. Tepper, A. Singhi, R. Dhir, Drwiega Paul, T. Smyrk, Lizhi Zhang, Paula Kim, Jay Bowen, J. Frick, J. Gastier-Foster, M. Gerken, Kevin R Lau, K. Leraas, T. Lichtenberg, N. Ramirez, Jeremy Renkel, M. Sherman, L. Wise, P. Yena, E. Zmuda, J. Shih, Adrian Ally, M. Balasundaram, R. Carlsen, Andy Chu, E. Chuah, A. Clarke, Noreen Dhalla, R. Holt, Steven J. M. Jones, Darlene Lee, Yussanne Ma, M. Marra, Michael Mayo, Richard A. Moore, A. Mungall, J. Schein, Payal Sipahimalani, Angela Tam, N. Thiessen, Kane Tse, Tina Wong, Denise Brooks, J. Auman, S. Balu, T. Bodenheimer, D. Hayes, A. Hoyle, S. Jefferys, Corbin D. Jones, S. Meng, P. Mieczkowski, Lisle E. Mose, C. Perou, Amy H. Perou, J. Roach, Yan Shi, J. Simons, Tara J. Skelly, Matthew G. Soloway, Donghui Tan, Umadevi Veluvolu, J. Parker, M. Wilkerson, Anil Korkut, Y. Şenbabaoğlu, P. Burch, R. McWilliams, K. G. Chaffee, A. Oberg, Wei Zhang, M. Gingras, D. Wheeler, Liu Xi, Monique Albert, J. Bartlett, H. Sekhon, Y. Stephen, Zaren Howard, M. Judy, A. Breggia, R. Shroff, Sudha Chudamani, Jia Liu, Laxmi Lolla, R. Naresh, T. Pihl, Qiang Sun, Yunhu Wan, Ye Wu, Smith Jennifer, K. Roggin, K. Becker, M. Behera, Joseph Bennett, L. Boice, E. Burks, C. G. C. Júnior, J. Chabot, D. Tirapelli, J. S. Santos, M. Dubina, J. Eschbacher, Meijuan Huang, L. Huelsenbeck-Dill, R. Jenkins, A. Karpov, R. Kemp, V. Lyadov, S. Maithel, G. Manikhas, E. Montgomery, H. Noushmehr, A. Osunkoya, T. Owonikoko, O. Paklina, O. Potapova, S. Ramalingam, W. Rathmell, K. Rieger-Christ, Charles Saller, G. Setdikova, A. Shabunin, G. Sica, T. Su, T. Sullivan, P. Swanson, Katherine Tarvin, M. Tavobilov, L. Thorne, S. Urbanski, Olga Voronina, Timothy C. Wang, D. Crain, Erin E. Curley, J. Gardner, D. Mallery, S. Morris, J. Paulauskis, R. Penny, C. Shelton, T. Shelton, K. Janssen, O. Bathe, N. Bahary, J. Slotta-Huspenina, A. Johns, H. Hibshoosh, R. Hwang, A. Sepulveda, Amie Radenbaugh, S. Baylin, Mario Berrios, Moiz Bootwalla, Andrea E Holbrook, Phillip H. Lai, D. Maglinte, S. Mahurkar, T. Triche, D. V. Berg, D. Weisenberger, L. Chin, R. Kucherlapati, M. Kucherlapati, A. Pantazi, P. Park, Douglas Voet, Pei Lin, S. Frazer, T. DeFreitas, S. Meier, S. Kwon, Y. Kim, Sang Jae Park, Sung-Sik Han, S. Kim, H. Kim, E. Furth, M. Tempero, C. Sander, A. Biankin, D. Chang, Peter Bailey, A. Gill, J. Kench, S. Grimmond, R. Postier, R. Zuna, H. Sicotte, John A. Demchok, M. Ferguson, C. Hutter, K. Shaw, Margi Sheth, H. Sofia, R. Tarnuzzer, Zhining Wang, Liming Yang, J. Zhang, Ina Felau, J. Zenklusen +265 moresemanticscholar +1 more sourceBioprinted Patient‐Derived Organoid Arrays Capture Intrinsic and Extrinsic Tumor Features for Advanced Personalized Medicine
Advanced Science, EarlyView.An embedded bioprinting enabled‐arrayed patient‐derived organoids (Eba‐PDO) platform that replicates intrinsic and extrinsic tumor characteristics is introduced. Eba‐PDOs more accurately mimic tissue than standard PDOs (Std‐PDOs) due to maturation in the tumor microenvironment.Jonghyeuk Han, Hye‐Jin Jeong, Jeonghan Choi, Hyeonseo Kim, Taejoon Kwon, Kyungjae Myung, Kyemyung Park, Jung In Park, Samuel Sánchez, Deok‐Beom Jung, Chang Sik Yu, In Ho Song, Jin‐Hyung Shim, Seung‐Jae Myung, Hyun‐Wook Kang, Tae‐Eun Park +15 morewiley +1 more source
