Results 181 to 190 of about 1,201,752 (348)

Classification of human lung carcinomas by mRNA expression profiling reveals distinct adenocarcinoma subclasses

Proceedings of the National Academy of Sciences of the United States of America, 2001
Arindam K Bhattacharjee, William G. Richards, J. Staunton, Cheng Li, Stefano Monti, P. Vasa, C. Ladd, J. Beheshti, Raphael Bueno, Michael A. Gillette, Massimo Loda, G. Weber, E. J. Mark, Eric S. Lander, W. Wong, B. E. Johnson, Todd R. Golub, D. Sugarbaker, M. Meyerson   +18 more
semanticscholar   +1 more source

Targeting UXS1‐Dependent Glucuronate Detoxification Potentiates Metformin's Anti‐Tumor Efficacy in Lung Adenocarcinoma

Advanced Science, EarlyView.
This study reveals that metformin promotes glucuronic acid metabolism in lung adenocarcinoma by activating UGDH S476 phosphorylation and enhancing the conversion of UDPG to UDPGA based on metabolomics analysis. Through compound virtual screening, it is found that plantainoside targeting UGDH downstream UXS1 leads to UDPGA toxicity accumulation ...
Qihai Sui, Zhencong Chen, Guangyao Shan, Zhengyang Hu, Xing Jin, Jiaqi Liang, Yanjun Yi, Jiacheng Yin, Haochun Shi, Xifei Jiang, Junjie Xi, Zongwu Lin, Cheng Zhan, Fenghao Sun, Wei Jiang   +14 more
wiley   +1 more source

RNF213 Is an Interferon‐Stimulated Gene That Targets Influenza A Virus NP and Activates MDA5 to Restrict Infection

Advanced Science, Volume 13, Issue 31, 4 June 2026.
RNF213 is characterized as a dual‐functional antiviral effector. It directly mediates the degradation of the influenza A virus nucleoprotein (NP) while simultaneously activating the MDA5‐mediated innate immune signaling pathway. This coordinated response establishes a powerful host defense system against viral infection. ABSTRACT Influenza A virus (IAV)
Haoning Li, Yuying Zhang, Jingjing Wang, Qianqian Zhang, Hailiang Sun, Fanhua Wei   +5 more
wiley   +1 more source

Identifying expression and DNA methylation biomarkers for lung adenocarcinoma risk in East Asia. [PDF]

J Natl Cancer Inst
Chen TY, Chien LH, Jiang SS, Choi J, Hung HH, Hsiao CF, Shi J, Blechter B, Breeze CE, Chang GC, Chen KY, Tsai YH, Su WC, Huang MS, Chen YM, Wen YF, Chen CY, Wang CL, Tsai FY, Chen HL, Hsieh WS, Lin HC, Wang LH, Chen CJ, Yang PC, Chen CY, Rothman N, Chanock SJ, Lan Q, Chang IS, Hsiung CA.   +30 more
europepmc   +1 more source

LMO7 Suppresses Tumor‐Associated Macrophage Phagocytosis of Tumor Cells Through Degradation of LRP1

Advanced Science, EarlyView.
LMO7 in tumor‐associated macrophages suppresses phagocytosis of tumor cells and limits cytotoxic T lymphocytes infiltration, fostering tumor progression. Mechanistically, LMO7 mediates the ubiquitination and degradation of the phagocytic receptor LRP1, impairing its ability to engulf tumor cells and driving macrophages toward an antitumor phenotype ...
Mengkai Li, Tao Wang, Yuwen Zhong, Zhiming Wang, Wei Li, Zejian Wang, Xinyi Yang, Yu Qiao, Jianfeng Xiang, Wei Gu, Zishu Wang, Lei Sun, Feng Qian   +12 more
wiley   +1 more source

Iris metastasis from lung adenocarcinoma diagnosed solely through aqueous humor cytology: A case report. [PDF]

Am J Ophthalmol Case Rep
Okubo A, Kanda S, Okinaga K, Ishii K, Aoki S, Kitamoto K, Terao R, Azuma K.   +7 more
europepmc   +1 more source

CDK4/6 Inhibition Induces CD8+ T Cell Antitumor Immunity via MIF‐Induced Functional Orchestration of Tumor‐Associated Macrophages

Advanced Science, EarlyView.
CDK4/6 inhibition promotes CD8+ T cell expansion through tumor‐macrophage crosstalk by activating HIF‐1α and enhancing MIF‐CD44/CD74 signaling. This reprograms TAMs to boost MHC‐I antigen presentation, and CDK4/6 inhibitor‐trained M1 TAM supernatant therapy synergizes with low‐dose PD‐1 blockade to restore antitumor immunity.
Lin He, Yuzhong Peng, Lat‐lun Leong, Jingbo Zhou, Dongyang Tang, Weilu Wang, Xiaoran Wu, Josh haipeng Lei, Yongqin Ye, Yangyang Feng, Yunfeng Qiao, Xiangpeng Chu, Di Mu, Qi Zhao, Tzuming Liu, Yan Chen, Paul Kwonghang Tam, Chu‐Xia Deng   +17 more
wiley   +1 more source

Marburg Virus Glycoprotein Is a Remarkable Virulent Factor Linked to Hemorrhagic Pathology: Evidence from Multimodal Experimental Systems

Advanced Science, EarlyView.
By integrating data from in vitro, ex vivo, and in vivo models, our research identifies the MARV glycoprotein as a remarkable hemorrhagic factor, filling a major gap in this important field. It also provides practical experimental tools for the basic research on viral pathogenesis and applied research aimed at antiviral intervention for hemorrhagic ...
Ting Yao, Hang Liu, Yanfeng Yao, Wei Deng, Jiawen Sun, Zhenyu Kang, Ashaq Ali, Chao Shan, Zhiming Yuan, Fei Deng, Hualin Wang, Yun‐Jia Ning   +11 more
wiley   +1 more source

Pancreatic Adenocarcinoma, Version 2.2017, NCCN Clinical Practice Guidelines in Oncology.

The Journal of the National Comprehensive Cancer Network, 2017
M. Tempero, M. Malafa, M. Al-Hawary, H. Asbun, Andrew J. Bain, S. Behrman, A. Benson, E. Binder, D. Cardin, Charles Cha, E. Chiorean, V. Chung, B. Czito, Mary E. Dillhoff, E. Dotan, C. Ferrone, J. Hardacre, W. Hawkins, J. Herman, A. Ko, S. Komanduri, A. Koong, N. Loconte, A. Lowy, C. Moravek, E. Nakakura, E. O’Reilly, Jorge V. Obando, S. Reddy, C. Scaife, S. Thayer, C. Weekes, R. Wolff, B. Wolpin, J. Burns, S. Darlow   +35 more
semanticscholar   +1 more source

Adenocarcinoma of the appendix

Journal of British Surgery, 1953
openaire   +2 more sources