Results 201 to 210 of about 1,279,856 (386)

Somatic mutations affect key pathways in lung adenocarcinoma

Nature, 2008
L. Ding, G. Getz, D. Wheeler, E. Mardis, M. McLellan, K. Cibulskis, C. Sougnez, H. Greulich, D. Muzny, M. Morgan, L. Fulton, R. Fulton, Qunyuan Zhang, M. Wendl, M. Lawrence, D. Larson, Ken Chen, D. Dooling, A. Sabo, A. Hawes, Hua Shen, S. Jhangiani, L. Lewis, O. Hall, Yiming Zhu, T. Mathew, Yanru Ren, Jiqiang Yao, S. Scherer, Kerstin Clerc, G. Metcalf, Brian Y. Ng, A. Milosavljevic, M. Gonzalez-Garay, John R. Osborne, R. Meyer, Xiaoqi Shi, Yuzhu Tang, D. Koboldt, Ling Lin, R. Abbott, T. Miner, C. Pohl, Ginger A. Fewell, C. Haipek, Heather K. Schmidt, Brian H. Dunford-Shore, A. Kraja, S. Crosby, Christopher Sawyer, T. Vickery, Sacha N Sander, J. Robinson, W. Winckler, J. Baldwin, L. Chirieac, A. Dutt, T. Fennell, M. Hanna, B. Johnson, R. Onofrio, Roman K. Thomas, G. Tonon, B. Weir, Xiaojun Zhao, L. Ziaugra, M. Zody, T. Giordano, M. Orringer, J. Roth, M. Spitz, I. Wistuba, B. Ozenberger, P. Good, A. Chang, D. Beer, M. Watson, M. Ladanyi, S. Broderick, A. Yoshizawa, W. Travis, W. Pao, M. Province, G. Weinstock, H. Varmus, S. Gabriel, E. Lander, R. Gibbs, M. Meyerson, R. Wilson   +89 more
semanticscholar   +1 more source

Lithium‐Charged Gold Nanoparticles: A New Powerful Tool for Lithium Delivery and Modulation of Glycogen Synthase Kinase 3 Activity

Advanced Materials, EarlyView.
This study introduces glutathione‐stabilized gold nanoparticles for targeted lithium delivery (LiG‐AuNPs), enabling the controlled modulation of Glycogen Synthase Kinase‐3 (GSK‐3β). These non‐toxic, 2‐nm particles release lithium intracellularly, effectively inhibiting GSK‐3β in the brain without significant plasma lithium alterations.
Antonio Buonerba, Giulia Puliatti, Domenica Donatella Li Puma, Bruno Bandiera, Beatrice Cannata, Maria Elena Marcocci, Nicolina Castagno, Irene Contento, Salvatore Impemba, Mariarosa Scognamiglio, Rocco Di Girolamo, Vincenzo Naddeo, Patrizia Canton, Carmine Capacchione, Laura Sposito, Martina Albini, Francesco Pastore, Silvia Baroni, Alfonso Grassi, Claudio Grassi, Roberto Piacentini   +20 more
wiley   +1 more source

BRCA 1/2 Germline Mutation Predicts the Treatment Response of FOLFIRINOX with Pancreatic Ductal Adenocarcinoma in Korean Patients [PDF]

, 2022
Ji Hoon Park, Jung Hyun Jo, Sung Ill Jang, Moon Jae Chung, Jeong Youp Park, Seungmin Bang, Seung Woo Park, Si Young Song, Hee Seung Lee, Jae Hee Cho   +9 more
openalex   +1 more source

Antibody‐Functionalized DNA Hydrogels Recognize and Isolate Living Tumor Cells

Advanced Materials Interfaces, EarlyView.
We present a novel strategy using DNA Y‐motif nanostar hydrogels and DNA‐functionalized antibodies for precise live‐cell manipulation. Target cells are labeled with DNA sticky ends that hybridize with DNA Y‐motifs, enabling their incorporation and capture within the hydrogel during self‐assembly.
Laura Bourdon, Audrey Cochard, Yannick Tauran, Yoshinobu Sugitani, Yusuke Sato, Masahiro Takinoue, Hiroyuki Fujita, Teruo Fujii, Soo Hyeon Kim, Anthony J. Genot   +9 more
wiley   +1 more source

A High Throughput Microfluidic Approach for the Continuous Manufacture of Ibuprofen Nanocrystals

Advanced Materials Technologies, EarlyView.
A robust, continuous manufacturing platform using a high‐throughput microfluidic reactor addresses key scalability challenges in pharmaceutical production. This process efficiently generates crystalline ibuprofen nanoparticles with superior control over size and distribution.
Shorooq Abukhamees, Maximilian Besenhard, Rawan Fitaihi, Hei Ming Kenneth Ho, Asterios Gavriilidis, Duncan Q. M. Craig   +5 more
wiley   +1 more source

Apoptotic death in adenocarcinoma cell lines induced by butyrate and other histone deacetylase inhibitors

, 1997
John A. McBain, Alan Eastman, Stefan Nobel, Gerald C. Mueller   +3 more
openalex   +1 more source

The Hippo signaling effector WWTR1 is a metastatic biomarker of gastric cardia adenocarcinoma [PDF]

, 2019
Jing Wei, Lincui Wang, Jun Zhu, Aiqin Sun, Guanzhen Yu, Miao Chen, Pan Huang, Hanqing Liu, Genbao Shao, Wannian Yang, Qiong Lin   +10 more
openalex   +1 more source

Cooperative Rh2(OAc)4/Chiral Phosphoric Acid‐Catalyzed (3 + 3)‐Cycloadditions of Pyrrole‐3‐Methides and Carbonyl Ylides

Advanced Synthesis &Catalysis, EarlyView.
A stereoselective one‐step (3 + 3)‐cycloaddition between in situ generated pyrrole‐3‐methides and carbonyl ylides has been developed using cooperative rhodium and chiral phosphoric acid catalysis. The reaction affords oxa‐bridged cyclohepta[1,2‐b]pyrroles bearing three stereogenic centers, including two quaternary ones, in high yields and ...
Philipp Stehr, Christoph Schneider
wiley   +1 more source

Phase‐Separation of YAP Mediates AJUBA Super Enhancer Activation to Promote Aberrant Mitosis in Breast Cancer

Advanced Science, EarlyView.
YAP undergoes phase separation to activate the AJUBA super‐enhancer, driving aberrant mitosis through spindle checkpoint dysregulation in breast cancer. This study uncovers a mechanistic link between YAP condensates, super‐enhancer activation, and aneuploidy formation.
Rui Zhang, Qingwen Huang, Zhuo Chen, Weijian Meng, Hongliang Dong, Zhihong Qi, Liang Liu, Jie Shen, Daxing Xie   +8 more
wiley   +1 more source

Prevalence and factors associated to the types of esophageal cancer in Arzobispo Loayza National Hospital during 2009 to 2013

Horizonte Médico, 2015
Objective: To determine the prevalence and the risk factors associated with the different types of esophageal cancer in Arzobispo Loayza National Hospital during 2009-2013. Materials and methods: This study was a retrospective cohort study.
Luis Andrés Norabuena Huapaya
doaj