Results 201 to 210 of about 823,307 (385)

The Nuclear Receptor NR1B1/RARα Arrests the Differentiation of Anti‐Tumor Effector Cytotoxic T Cells

Advanced Science, EarlyView.
RARα is highly expressed by differentiated effector and exhausted T cells and exerts a negative effect on effector T cell differentiation and the associated trafficking receptor switch. Upregulated RARα levels decrease the nuclear histone acetylase (HAT) activity, and this suppresses the expression of key Teff transcription factor BATF and trafficking ...
Patrick Niekamp, Ryun Hee Kim, Adithyan Jayaraman, Nils Klement, Raymond Kostlan, Chang H. Kim   +5 more
wiley   +1 more source

Frailty and surgical outcomes in gastrointestinal cancer: Integration of geriatric assessment and prehabilitation into surgical practice for vulnerable patients

Annals of Gastroenterological Surgery, Volume 7, Issue 1, Page 27-41, January 2023., 2023
Accumulating evidence demonstrates that the integration of preoperative geriatric assessment and prehabilitation for frail patients into clinical practice may improve perioperative and long‐term outcomes in patients with gastrointestinal cancer. We proposed an example for the integration of older patients‐specific care into treatment strategies for ...
Kosuke Mima, Shigeki Nakagawa, Tatsunori Miyata, Yo‐ichi Yamashita, Hideo Baba   +4 more
wiley   +1 more source

USP4 promotes proliferation and metastasis in human lung adenocarcinoma. [PDF]

Sci Rep
Wei Y, Wei S, Lei Z, Zhang Y, Wu J, Huang J, Fu L, Li Z, Huang G, Liang Y, Zheng J.   +10 more
europepmc   +1 more source

DNA Origami‐Cyanine Nanocomplex for Precision Imaging of KRAS‐Mutant Pancreatic Cancer Cells

Advanced Science, EarlyView.
DNA origami‐cyanine (Do‐Cy) nanocomplexes are synthesized to selectively image KRAS‐mutant pancreatic cancer cells in the highly desmoplastic tumors. This study shows that the Do‐Cy nanocomplexes are preferentially internalized by cancer cells over other stroma cells via KRAS‐dependent macropinocytosis.
Hye‐ran Moon, Yancheng Du, Sae Rome Choi, Seongmin Seo, Cih Cheng, Bennett D. Elzey, Jong Hyun Choi, Bumsoo Han   +7 more
wiley   +1 more source

Differences in prognosis and underuse of adjuvant chemotherapy between elderly and non‐elderly patients in stage III colorectal cancer

Annals of Gastroenterological Surgery, Volume 7, Issue 1, Page 91-101, January 2023., 2023
This study analyzed data from consecutive patients with stage III colorectal cancer following curative resection and examined the reason for not introducing adjuvant chemotherapy (AC) and the differences in prognosis between completed and incomplete AC in elderly and non‐elderly patients.
Takuya Shiraishi, Hiroomi Ogawa, Ikuma Shioi, Naoya Ozawa, Katsuya Osone, Takuhisa Okada, Makoto Sohda, Ken Shirabe, Hiroshi Saeki   +8 more
wiley   +1 more source

Mechanism of astragaloside A against lung adenocarcinoma based on network pharmacology combined with molecular dynamics simulation technique. [PDF]

Sci Rep
Ding J, Xue Q, Guo W, Cheng G, Zhang L, Huang T, Wu D, Tong J, Yang C, Gao Y, Li Z.   +10 more
europepmc   +1 more source

Acinic cell adenocarcinoma of minor salivary glands [PDF]

, 1978
Ssu‐Yuan Chen, Robert B. Brannon, Arthur S. Miller, D. K. White, S. P. Hooker   +4 more
openalex   +1 more source

Gastric adenocarcinoma

, 2020
openaire   +1 more source

Targeting Replication Fork Processing Synergizes with PARP Inhibition to Potentiate Lethality in Homologous Recombination Proficient Ovarian Cancers

Advanced Science, EarlyView.
This study demonstrates that the resveratrol analogue, trans‐4,4′‐dihydroxystilbene (DHS), exhibits synergistic anti‐tumor activity with the PARP inhibitor talazoparib, inducing significant ovarian cancer cell death. The synergistic effect of this combination arises from the concurrent downregulation of homologous recombination factors and the ...
Ganesh Pai Bellare, Kshama Kundu, Papiya Dey, Krupa Thankam Philip, Nitish Chauhan, Muskan Sharma, Sankarsingh Kesharsingh Rajput, Birija Sankar Patro   +7 more
wiley   +1 more source

Survival outcomes of laparoscopic versus open total gastrectomy with nodal dissection for gastric cancer in a high‐volume Japanese center: A propensity score‐matched analysis

Annals of Gastroenterological Surgery, Volume 7, Issue 1, Page 53-62, January 2023., 2023
To compare the survival outcomes of laparoscopic total gastrectomy (LTG) with those of open total gastrectomy (OTG), 580 patients were enrolled and 1:1 propensity score matching was implemented to reduce selection bias. Five‐year overall survival was better in the LTG group, and there was no significant difference in overall survival according to ...
Takahiro Kinoshita, Eigo Akimoto, Masahiro Yura, Mitsumasa Yoshida   +3 more
wiley   +1 more source