Results 211 to 220 of about 1,279,856 (386)

Classification of human lung carcinomas by mRNA expression profiling reveals distinct adenocarcinoma subclasses

Proceedings of the National Academy of Sciences of the United States of America, 2001
Arindam Bhattacharjee, William G. Richards, Jane Staunton, Cheng Li, Stefano Monti, Priya Vasa, C. Ladd, J. Beheshti, Raphael Bueno, Michael A. Gillette, Massimo Loda, G. Weber, Eugene J. Mark, Eric S. Lander, W. Wong, Bruce E. Johnson, Todd R. Golub, D. Sugarbaker, M. Meyerson   +18 more
semanticscholar   +1 more source

Obesity‐Associated TRIM15 Promotes the Proliferation of Esophageal Adenocarcinoma Through the YY2/FOXRED1 Axis

Advanced Science, EarlyView.
The study identifies TRIM15 as a key driver in the development of obesity‐associated esophageal adenocarcinoma (EAC). Mechanistically, TRIM15 degrades YY2 through the proteasome pathway, suppressing FOXRED1 transcription and ultimately accelerating tumor proliferation.
Haohui Wang, Chong Yang, Dayuan Luo, Pingting Liu, Zhen Zeng, Weilin Peng, Dongzi Peng, Hao Su, Xiaoxiong Xiao, Haiqin Wang, Xin Jin   +10 more
wiley   +1 more source

HERV‐K TM Subunit Elicits CD8+ T Cell Anergy and Tumor Immune Evasion via Targeting CD3 Coreceptor ε in AML and PDAC

Advanced Science, EarlyView.
Novel viral immune checkpoint K‐TM subunit is aberrantly expressed in CD8+ T cells and enriched in sera of cancer patients, inducing CD8+ T cell anergy and eliciting potent tumor immune escape in mouse model. Mechanistically, K‐TM directly targets and induces the phosphorylation of CD3ε receptor.
Mengyuan Li, Shuwen Zheng, Qinyuan Gong, Zhaoxing Wu, Wen Lei, Wanyue Cao, Ping Wang, Xuzhao Zhang, Wenbin Qian, Yun Liang, Ying Lu, Fenglin Li, Qi Zhang, Rongzhen Xu   +13 more
wiley   +1 more source

DKK3 Initially Preserves Acinar Integrity Through MEK‐Fos Signaling, but Later Switches to an Oncogenic Role in Pancreatic Cancer

Advanced Science, EarlyView.
In pancreatic cancer, the protein DKK3 is found to play a complex role: it initially slows early tumor growth but later promotes tumor aggressiveness. DKK3 expression evolves during progression and drives cancer severity by orchestrating cellular and molecular signaling pathways.
Dharini Srinivasan, Elodie Roger, Lukas Perkhofer, Eleni Zimmer, Thomas F.E. Barth, Julia P. Mosler, Anna Härle, Stephanie E. Weissinger, Nadine T. Gaisa, Peter Möller, Nico Fischer, Chantal Allgöwer, J.‐Matthias Löhr, Dirk Grimm, Thomas Seufferlein, Stefan Liebau, Ninel Azoitei, Michael K. Melzer, Frank Arnold, Johann Gout, Alexander Kleger   +20 more
wiley   +1 more source

Pancreatic ductal adenocarcinoma: long-term survival does not equal cure.

Surgery, 2012
C. Ferrone, R. Pieretti-Vanmarcke, Jordan P Bloom, Hui Zheng, Jackye Szymonifka, J. Wargo, S. Thayer, G. Lauwers, V. Deshpande, Mari Mino-Kenudson, C. F. Fernandez-Del Castillo, K. D. Lillemoe, A. Warshaw   +12 more
semanticscholar   +1 more source

Cancer Immunotherapy via Disruption of Integrin αvβ3 and CD47 Costabilization on Cancer Cell Surface

Advanced Science, EarlyView.
This study identifies a cancer‐specific interaction between CD47 and integrin αvβ3 that facilitates immune evasion. A rationally designed peptide, PSFL‐NK13, disrupts this axis, enhancing macrophage‐mediated phagocytosis and suppressing tumor growth without inducing anemia.
Peng‐Cheng Yu, Chen‐Xi Yue, Wen‐Zhong Dong, Cui‐Yun Hao, Yi‐Fan Qiao, Di Liu, Xin Zhang, Qi Zhan, Jia‐Bao Yao, Dong‐Ping Wang, Peng Cao, Ying‐Zhe Fan, Ye Yu   +12 more
wiley   +1 more source

Second Primary Lung Cancer Associated With Family History of Lung Cancer. [PDF]

Cancer Med
Zitricky F, Sundquist K, Sundquist J, Försti A, Hemminki A, Hemminki K.   +5 more
europepmc   +1 more source

Deacetylation of ACLY Mediates RNA M6A‐Modification of NOXA and Promotes Chemoresistance of Colorectal Cancer

Advanced Science, EarlyView.
This study investigates the deacetylation of ACLY at K978 acts as a novel risk in colorectal cancer chemoresistance. The deacetylation of K978 induces ACLY relocation to the nucleus and promotes its binding to RBM15, a m6A methylation modification “writer”.
Jun Wen, Mengqin Shen, Haitao Zhao, Liu Liu, Qian Hua, Xiaoping Zhao, Jianjun Liu, Haizhong Feng, Gang Huang   +8 more
wiley   +1 more source

Stage- and smoking-associated microRNA expression in lung adenocarcinoma. [PDF]

Transl Lung Cancer Res
Huang M, Ge Y, Chen H, Wei C, Cogdell D, Ivan C, Chen M, Zhang W, Calin GA, Guo M.   +9 more
europepmc   +1 more source

Pancreatic Adenocarcinoma, Version 2.2017, NCCN Clinical Practice Guidelines in Oncology.

The Journal of the National Comprehensive Cancer Network, 2017
M. Tempero, M. Malafa, M. Al-Hawary, H. Asbun, Andrew J. Bain, S. Behrman, A. Benson, E. Binder, D. Cardin, Charles Cha, E. Chiorean, V. Chung, B. Czito, Mary E. Dillhoff, E. Dotan, C. Ferrone, J. Hardacre, W. Hawkins, J. Herman, A. Ko, S. Komanduri, A. Koong, N. Loconte, A. Lowy, C. Moravek, E. Nakakura, E. O’Reilly, Jorge V. Obando, S. Reddy, C. Scaife, S. Thayer, C. Weekes, R. Wolff, B. Wolpin, J. Burns, S. Darlow   +35 more
semanticscholar   +1 more source