Results 231 to 240 of about 672,479 (309)

Designing Tissue Function Through Embedded Bioprinting Architectures

open access: yesAdvanced Science, EarlyView.
Embedded bioprinting enables soft, cell‐dense constructs to be fabricated within supporting bath environments. This review introduces a function‐guided framework linking target tissue functions to architectural requirements, supporting bath selection, bioink design, printing dynamics, and validation assays.
Qi Li   +4 more
wiley   +1 more source

Targeting the PHB2–ACSL3 Lipid‐Remodeling Axis Overcomes Cisplatin Resistance by Restoring Ferroptosis in Gastric Cancer

open access: yesAdvanced Science, EarlyView.
ABSTRACT Platinum‐based chemotherapy resistance remains a major obstacle in gastric cancer (GC) treatment. Through integrated transcriptomic profiling of cisplatin‐resistant xenografts and pharmacogenomic interrogation of the NCI‐60 dataset, we identified Prohibitin‐2 (PHB2) as a previously unrecognized determinant of chemoresistance.
Liang Xu   +10 more
wiley   +1 more source

Tissue‐Agnostic Cellular Morphometric Biomarkers for Risk‐Adapted Management Across Gastrointestinal Precancerous Lesions and Cancers

open access: yesAdvanced Science, EarlyView.
An interpretable, unsupervised artificial intelligence framework identifies a 13‐cellular morphometric biomarker (CMB) signature from routine H&E whole‐slide images. Validated across 2,602 patients, the fixed signature generalizes across colorectal, gastric, and esophageal tissues without retraining, stratifies prognosis and precancerous lesion risk ...
Pin Wang   +14 more
wiley   +1 more source

Ectopic Pancreatic Adenocarcinoma Arising in the Mesentery of the Jejunum: A Case Report. [PDF]

open access: yesSurg Case Rep
Furusho I   +11 more
europepmc   +1 more source

AL398, A Novel NSUN6 Inhibitor, Attenuates Epithelial‐Mesenchymal Transition and Metastasis in Endometrial Cancer by Abrogating m5C‐Dependent Stabilization of Snail mRNA

open access: yesAdvanced Science, EarlyView.
Proposed molecular mechanism: NSUN6 catalyzes m5C methylation on Snail mRNA to enhance its stability, leading to Snail upregulation and EMT promotion. The first‐in‐class inhibitor AL398 suppresses endometrial cancer metastasis by targeting the NSUN6‐m5C‐Snail. axis. ABSTRACT Endometrial cancer (EC) constitutes a leading gynecologic malignancy for which
Xiangzhuan Zhao   +19 more
wiley   +1 more source

A Case of Cecal Mixed Neuroendocrine-Non-Neuroendocrine Neoplasm Requiring Adjuvant Chemotherapy Based on Comprehensive Pathological Assessment. [PDF]

open access: yesSurg Case Rep
Yokoi R   +11 more
europepmc   +1 more source

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