Results 241 to 250 of about 1,187,996 (336)

Hypofractionated Radiotherapy Induces ISG15+MHC‐I+ Neutrophils to Augment Anti‐Tumor Immunity and Prime Immune Checkpoint Blockade Responses in Rectal Cancer

Advanced Science, EarlyView.
ABSTRACT Our previous clinical trials had demonstrated that neoadjuvant hypofractionated radiotherapy (HFRT) combined with immunotherapy yields promising clinical outcomes in locally advanced rectal cancer (LARC). However, this combined modality benefits only a subset of patients, highlighting the need to uncover the mechanisms underlying how ...
Lichao Liu, Haihong Wang, Mingjie Li, Qian Xu, Linlin Zheng, Chaoqun Han, Zhenwei Zou, Jinghua Ren, Xiaorong Dong, Peng Zhang, Kaixiong Tao, Zhenyu Lin, Tao Zhang   +12 more
wiley   +1 more source

Clinical predictors of leptomeningeal metastasis from lung adenocarcinoma based on retrospective analysis. [PDF]

Oncol Lett
Lu Y, Lu Y, Zhang Y, Du H, Cao X, Jin D, Chen G, Yang X.   +7 more
europepmc   +1 more source

A comparison of multimodal therapy and surgery for esophageal adenocarcinoma.

New England Journal of Medicine, 1996
T. Walsh, N. Noonan, D. Hollywood, A. Kelly, N. Keeling, T. Hennessy   +5 more
semanticscholar   +1 more source

DMAP1 Deficiency Suppresses Lung Cancer Progression by Destabilizing Replication Fork and Activating IFN Signaling‐Mediated Anti‐tumor Immunity

Advanced Science, EarlyView.
Lung cancer remains the leading cause of cancer‐related death. We investigated the role of the epigenetic regulator DMAP1 in NSCLC and found that its loss induces replication stress and DNA damage. This in turn activates type I IFN signaling via the cGAS–STING pathway and transcriptional ISG de‐repression, enhancing anti‐tumor immune responses ...
Kan Huang, Xi Dai, Shuaihu Li, Yingxue Chen, Yaxin Yu, Lin Wang, Kun Liu, Shuhan Lyu, Chongyang Li, Yihua Sun, Fei Li   +10 more
wiley   +1 more source

Complete pathological response to neoadjuvant chemoradiotherapy in Crohn's disease-associated fistula adenocarcinoma: a case report. [PDF]

Front Med (Lausanne)
Dahmeni W, Souilem E, Hassen H, Ghdiri Y, Ahlem Z, Dahmoul A, Slama AB, Brahem A, Jaziri H, Mestiri S, Elleuch N, Hmissa S, Ksiaa M.   +12 more
europepmc   +1 more source

International Endocervical Adenocarcinoma Criteria and Classification (IECC): A New Pathogenetic Classification for Invasive Adenocarcinomas of the Endocervix

American Journal of Surgical Pathology, 2018
S. Stolnicu, Iulia Bârsan, L. Hoang, Prusha Patel, C. Terinte, A. Pesci, S. Aviel‐Ronen, T. Kiyokawa, I. Alvarado-Cabrero, M. Pike, E. Oliva, Kay J. Park, R. Soslow   +12 more
semanticscholar   +1 more source

The AUTACE That Degrades KRAS and Engages CD8+ T Cells for the Treatment of KRAS/TP53 Co‐Mutant Tumors

Advanced Science, EarlyView.
AUTACE is a bifunctional nanoplatform that integrates tumor targeting, immune engagement, and on‐demand KRAS degradation. It targets KRAS/TP53 co‐mutant tumors via TP53‐specific TCRs, elicits antitumor CD8+ T‐cell responses through surface anti‐CD3 antibodies, and uses low‐intensity focused ultrasound (LIFU) to trigger controlled release of the KRAS ...
Luo Li, Bolin Li, Yanan Hao, Bo Pang, Pan Li, Chunli Li, Yu Tang   +6 more
wiley   +1 more source

Pleomorphic Carcinoma With EGFR and Concomitant Mutations Transformed From Lung Adenocarcinoma: A Case Report. [PDF]

Cancer Rep (Hoboken)
Akazawa Y, Sato T, Yagami Y, Kesen Y, Furo T, Watanabe A, Endo J, Nakano M, Kurata H, Matsuo H, Nakahara Y, Sasaki J, Naoki K.   +12 more
europepmc   +1 more source

MicroRNA expression profiles associated with prognosis and therapeutic outcome in colon adenocarcinoma.

Journal of the American Medical Association (JAMA), 2008
Aaron J Schetter, S. Leung, Jane J. Sohn, Krista A. Zanetti, E. Bowman, N. Yanaihara, S. Yuen, T. Chan, D. Kwong, G. Au, Chang-Gong Liu, G. Calin, C. Croce, C. Harris   +13 more
semanticscholar   +1 more source

Context‐Dependent Role of GDF15: GDF15+ Tumor‐Associated Macrophages Suppress OSCC Progression by Enhancing Phagocytosis

Advanced Science, EarlyView.
This study identifies GDF15+ TAMs as a cell subset mediating tumor regression after immunotherapy. Macrophage‐intrinsic GDF15 enhances phagocytosis and antigen cross‐presentation to CD8+ T cells through the NF‐κB signaling pathway, thereby inhibiting tumor progression.
Xinyu Zhou, Zhihang Zhou, Houyu Ju, Chaoyang Guo, Fangxing Zhu, Yiyi Zhang, Xu Chen, Tongchao Zhao, Laiping Zhong, Jingzhou Hu   +9 more
wiley   +1 more source