Results 1 to 10 of about 132,293 (166)

Pasireotide for Refractory Hypoglycemia in Malignant Insulinoma- Case Report and Review of the Literature

Frontiers in Endocrinology, 2022
Malignant insulinomas are functional neuroendocrine tumors of the pancreas and the primary cause of tumor-related hypoglycemia. Malignant insulinoma is rare and has a poor prognosis.
Sandrine Oziel-Taieb, Jemima Maniry-Quellier, Brice Chanez, Flora Poizat, Jacques Ewald, Patricia Niccoli   +5 more
doaj   +1 more source

Methylmalonic acid promotes colorectal cancer progression via activation of Wnt/β-catenin pathway mediated epithelial–mesenchymal transition

Cancer Cell International, 2023
Background It has been manifested in several studies that age-related metabolic reprogramming is associated with tumor progression, in particular, colorectal cancer (CRC).
Chunhua Hu, Mujie Ye, Jianan Bai, Pengfei Liu, Feiyu Lu, Jinhao Chen, Ping Yu, Tiaotiao Chen, Xiaoting Shi, Qiyun Tang   +9 more
doaj   +1 more source

Down-regulated FTO and ALKBH5 co-operatively activates FOXO signaling through m6A methylation modification in HK2 mRNA mediated by IGF2BP2 to enhance glycolysis in colorectal cancer

Cell & Bioscience, 2023
Background N6-methyladenosine (m6A) modification is the most abundant reversible methylation modification in eukaryotes, and it is reportedly closely associated with a variety of cancers progression, including colorectal cancer (CRC).
Mujie Ye, Jinhao Chen, Feiyu Lu, Minghui Zhao, Suwen Wu, Chunhua Hu, Ping Yu, Jingbao Kan, Jianan Bai, Ye Tian, Qiyun Tang   +10 more
doaj   +1 more source

ALKBH5 enhances lipid metabolism reprogramming by increasing stability of FABP5 to promote pancreatic neuroendocrine neoplasms progression in an m6A-IGF2BP2-dependent manner

Journal of Translational Medicine, 2023
The process of post-transcriptional regulation has been recognized to be significantly impacted by the presence of N6-methyladenosine (m6A) modification.
Jinhao Chen, Mujie Ye, Jianan Bai, Zhihui Gong, Lijun Yan, Danyang Gu, Chunhua Hu, Feiyu Lu, Ping Yu, Lin Xu, Yan Wang, Ye Tian, Qiyun Tang   +12 more
doaj   +1 more source

FAM201A encodes small protein NBASP to inhibit neuroblastoma progression via inactivating MAPK pathway mediated by FABP5

Communications Biology, 2023
Increasing evidence indicates that long non-coding RNA (lncRNA) is one of the most important RNA regulators in the pathogenesis of neuroblastoma (NB). Here, we found that FAM201A was low expressed in NB and a variety of gain and loss of function studies ...
Mujie Ye, Runnan Gao, Shiyu Chen, Jianan Bai, Jinhao Chen, Feiyu Lu, Danyang Gu, Xiaoting Shi, Ping Yu, Ye Tian, Qiyun Tang, Kuiran Dong   +11 more
doaj   +1 more source

Limited Diagnostic Utility of Chromogranin A Measurements in Workup of Neuroendocrine Tumors

Diagnostics, 2020
Background: Plasma chromogranin A (CgA) is related to tumor burden and recommended in the follow-up of patients diagnosed with neuroendocrine tumors (NETs). The use of CgA in the workup of a suspected NET is more questionable.
Jonas Baekdal, Jesper Krogh, Marianne Klose, Pernille Holmager, Seppo W. Langer, Peter Oturai, Andreas Kjaer, Birgitte Federspiel, Linda Hilsted, Jens F. Rehfeld, Ulrich Knigge, Mikkel Andreassen   +11 more
doaj   +1 more source

Transcatheter arterial embolization in patients with neuroendocrine neoplasms related to liver metastasis with different blood supplies

Cancer Medicine, 2023
Purpose Liver metastasis is one of the most important factors affecting the prognosis of patients with neuroendocrine neoplasms (NENs). Transhepatic artery embolization (TAE) is the main local treatment of NENs with liver metastasis (NENLM).
Jianan Bai, Jinhua Song, Yang Zhang, Xiaolin Li, Lijun Yan, Ping Hu, Qiyun Tang   +6 more
doaj   +1 more source

Neuroendocrine Carcinomas of the Gastroenteropancreatic System: A Comprehensive Review

Diagnostics, 2015
To date, empirical literature has generally been considered lacking in relation to neuroendocrine carcinomas (NECs), the highly malignant subgroup of neuroendocrine neoplasms.
Emma Elizabeth Ilett, Seppo W. Langer, Ingrid Holst Olsen, Birgitte Federspiel, Andreas Kjær, Ulrich Knigge   +5 more
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P53, Somatostatin receptor 2a and Chromogranin A immunostaining as prognostic markers in high grade gastroenteropancreatic neuroendocrine neoplasms

BMC Cancer, 2020
Background High grade gastroenteropancreatic (GEP) neuroendocrine neoplasms (NEN) with a Ki67 proliferation index > 20%, include well-differentiated tumours grade 3 (NET G3) and poorly differentiated (PD) neuroendocrine carcinomas (NEC).
Kirstine Nielsen, Tina Binderup, Seppo W. Langer, Andreas Kjaer, Pauline Knigge, Veronica Grøndahl, Linea Melchior, Birgitte Federspiel, Ulrich Knigge   +8 more
doaj   +1 more source

Recent epidemiology of patients with gastro-entero-pancreatic neuroendocrine neoplasms (GEP-NEN) in Japan: a population-based study

BMC Cancer, 2020
Background The worldwide prevalence and incidence of neuroendocrine neoplasms (NEN) have been increasing recently, although few studies have analyzed data on the current situation of NENs in Japan.
Toshihiko Masui, Tetsuhide Ito, Izumi Komoto, Shinji Uemoto, JNETS Project Study Group   +4 more
doaj   +1 more source