Results 311 to 320 of about 3,117,738 (383)

Nuclear to Cytoplasmic Transport Is a Druggable Dependency in HDAC7‐driven Small Cell Lung Cancer

Advanced Science, Volume 12, Issue 14, April 10, 2025.
This work reports that a HDAC7‐high SCLC subtype is associated with enhanced proliferation and a poor prognosis. Furthermore, nuclear‐to‐cytoplasmic transport is emerged as a druggable dependency in HDAC7‐mediated SCLC. Elevated HDAC7 predicts increase sensitivity to selinexor both in vitro and in patient‐derived organoids.
Tingting Qin, Jingya Wang, Jian Wang, Qingwu Du, Liuchun Wang, Hailin Liu, Wenting Liu, Xueyang Li, Yantao Jiang, Qi Xu, Junjie Yu, Huiyan Liu, Ting Wang, Mengjie Li, Dingzhi Huang   +14 more
wiley   +1 more source

Desmoglein 3 and Keratin 14 for Distinguishing Between Lung Adenocarcinoma and Lung Squamous Cell Carcinoma. [PDF]

Onco Targets Ther, 2020
Dong Y, Li S, Sun X, Wang Y, Lu T, Wo Y, Leng X, Kong D, Jiao W.   +8 more
europepmc   +1 more source

A Case of Small Peripheral Lung Adenocarcinoma with Remarkable Invasion of Bronchial Submucosal Lymph Ducts.

, 1998
Ko Tsuji, Takashi Hirano, Norihiko Kawate, Chimori Konaka, Yoshiro Ebihara, Harubumi Kato   +5 more
openalex   +2 more sources

LincNEAT1 Encoded‐NEAT1‐31 Promotes Phagocytosis by Directly Activating the Aurora‐A–PI3K–AKT Pathway

Advanced Science, EarlyView.
LincNEAT1 Encoded‐NEAT1‐31 micropeptide directly binds with Aurora‐A and enhanced AKT pathways to pormotes phagocytosis against multi cancer cells. Abstract Macrophages play vital roles in innate and adaptive immunity, and their essential functions are mediated by phagocytosis and antigen presentation.
Jie Li, Jing Zhang, Xixi Li, Xin Liu, Bo Zeng, Jiayue Luo, Huijin Wang, Hanbing Zhang, Xinya Gao   +8 more
wiley   +1 more source

Electron Microscopic Morphometry of the Nucleus and its Clinical Significance in Adenocarcinoma of the Lung.

, 1995
Tomohiko Ikeya, Shigeki Sugiyama, Takurou Misaki   +2 more
openalex   +2 more sources

Meisoindigo Acts as a Molecular Glue to Target PKMYT1 for Degradation in Chronic Myeloid Leukemia Therapy

Advanced Science, EarlyView.
Meisoindigo targets PKMYT1 for degradation by acting as a molecular glue that enhances PKMYT1‐TRIM25 interaction, leading to K48‐linked ubiquitination and subsequent proteasomal degradation, thereby exerting therapeutic effects in chronic myeloid leukemia.
Zhao‐Xin Zhang, Shu‐Ying Li, Fang‐Fei Li, Qin‐Yan Shi, Cheng‐Yong Tan, Xiao‐Jing Wang, Mi Li, Yun‐Bao Liu, Jing Jin, Yong Li, Shi‐Shan Yu   +10 more
wiley   +1 more source

A CLDN18.2‐Targeted Nanoplatform Manipulates Magnetic Hyperthermia Spatiotemporally for Synergistic Immunotherapy in Gastric Cancer

Advanced Science, Volume 12, Issue 16, April 24, 2025.
CLDN18.2 is a highly selective biomarker exposed in gastric cancer. A CLDN18.2‐specific antibody 1D5 conjugated fluorescence‐magnetic nanoparticle is developed for image‐guided precision theragnostics. Under the assistance of sensitive FMI and deep‐penetrating MPI for tracing and timing the optimal nanoparticle dosage, combining α‐PD1 therapy with ...
Xueying Wang, Hui Hui, Jing Han, Ting Guo, Yiding Wang, Lin Meng, Cong Chen, Jie He, Xiaoyong Guo, Fuyu Zhong, Hong Du, Jie Tian, Xiaofang Xing, Yang Du, Jiafu Ji   +14 more
wiley   +1 more source

TRIM56 Promotes White Adipose Tissue Browning to Attenuate Obesity by Degrading TLE3

Advanced Science, Volume 12, Issue 13, April 3, 2025.
This study pinpoints TRIM56 as a viable candidate for promoting white adipose tissue browning and as a promising therapeutic target for addressing obesity and metabolic disorders. Functioning as an E3 ubiquitin ligase, TRIM56 facilitates the degradation of the TLE3 protein, thereby accelerating the thermogenic process and enhancing energy expenditure ...
Haojie Qin, Yi Zhong, Jinhui Huang, Yanli Miao, Meng Du, Kai Huang   +5 more
wiley   +1 more source

A Versatile High‐Throughput Single‐Cell Screening Platform for Profiling Antigen‐Specific Long‐Lived B Cells in Blood and Bone Marrow

Advanced Science, EarlyView.
The MoSMAR‐chip platform provides a high‐throughput and cost‐effective tool for identifying and characterizing antigen‐specific antibody‐secreting cells (ASCs) and memory B cells (MBCs) at the single‐cell level. The ASCs from coronavirus disease 2019 (COVID‐19) vaccine‐immunized mice were successfully analyzed, revealing diverse neutralizing antibodies
Tian Zhao, Yuqing Lei, Chang Liu, Dong Zhang, Kaiyi Li, Sisi Shan, Chenyu Li, Zimeng Wei, Yuhan Yang, Ting Zhang, Kai Sun, Haoran Sun, Linqi Zhang, Peng Liu   +13 more
wiley   +1 more source

Transcriptome Landscape of Cancer‐Associated Fibroblasts in Human PDAC

Advanced Science, EarlyView.
AP‐1 family members FOS and JUN regulate the malignant phenotype conversion of normal fibroblasts (NFs) to normal‐like cancer‐associated fibroblasts (nCAFs), while transforming growth factor‐β (TGFβ) and interferon‐γ (IFNγ) signals triggers the interconversion between classic myofibroblastic CAFs (myCAFs) and inflammatory CAFs (iCAFs), respectively ...
Mengyu Tao, Wenting Liu, Jianhua Chen, Rujiao Liu, Jianling Zou, Bo Yu, Chenchen Wang, Mingzhu Huang, Qingjian Chen, Zhe Zhang, Zhiyu Chen, Haoyu Sun, Cheng Zhou, Shuguang Tan, Yuxuan Zheng, Hongxia Wang   +15 more
wiley   +1 more source