Inhibition of adenosine/A2A receptor signaling suppresses dermal fibrosis by enhancing fatty acid oxidation [PDF]
Cell Communication and SignalingBackground Skin fibrosis presents a major challenge for clinicians treating conditions like systemic sclerosis (SSc) due to its progressive course and limited treatment options.
Xiaoye Zhang +9 more
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Role of adenosine A2a receptor in cancers and autoimmune diseases. [PDF]
Immun Inflamm Dis, 2023 Adenosine receptors are P1 class of purinergic receptors that belong to G protein‐coupled receptors. There are 4 subtypes of adenosine receptors, namely A1, A2A, A2B, and A3. A2AR has a high affinity for the ligand adenosine.
Ye H +6 more
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Adenosine-A2A Receptor Pathway in Cancer Immunotherapy. [PDF]
Front Immunol, 2022 A2A receptors (A2AR), a typical GPCR with a high affinity for adenosine, was expressed in many immune cells, such as regulatory T cells, cytotoxic T cells, macrophages, etc.
Sun C, Wang B, Hao S.
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Dual roles of the adenosine A2a receptor in autoimmune neuroinflammation [PDF]
Journal of Neuroinflammation, 2016 Conditions of inflammatory tissue distress are associated with high extracellular levels of adenosine, due to increased adenosine triphosphate (ATP) degradation upon cellular stress or the release of extracellular ATP upon cell death, which can be ...
Jens Ingwersen +11 more
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Characterization of the trigeminovascular actions of several adenosine A2A receptor antagonists in an in vivo rat model of migraine [PDF]
The Journal of Headache and Pain, 2018 Background Migraine is considered a neurovascular disorder, but its pathophysiological mechanisms are not yet fully understood. Adenosine has been shown to increase in plasma during migraine attacks and to induce vasodilation in several blood vessels ...
Kristian A. Haanes +10 more
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Frontiers in Immunology, 2017 The lack of a functional Foxp3 transcription factor and regulatory T (Treg) cells causes lethal, CD4+ T cell-driven autoimmune diseases in scurfy (SF) mice and humans.
Baokun He +4 more
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Adenosine A2A receptor agonist ameliorates EAE and correlates with Th1 cytokine‐induced blood brain barrier dysfunction via suppression of MLCK signaling pathway [PDF]
Immunity, Inflammation and Disease, 2018 Introduction Multiple sclerosis (MS) disease activity is associated with blood‐brain barrier (BBB) disruption, which is mediated by inflammatory cytokines released by CD4+ lymphocytes.
Ying Liu +4 more
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Adenosine A2A Receptor: A New Neuroprotective Target in Light-Induced Retinal Degeneration [PDF]
Frontiers in Pharmacology, 2022 Continuous illumination induces the degeneration of photoreceptors. This animal model of light-induced retinal degeneration resembles many characteristics of human degenerative diseases of the outer retina, such as age-related macular degeneration.
Manuel Soliño +8 more
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Adenosine A2A receptor agonists with potent antiplatelet activity
Platelets, 2018 Selected adenosine A2A receptor agonists (PSB-15826, PSB-12404, and PSB-16301) have been evaluated as new antiplatelet agents. In addition, radioligand-binding studies and receptor-docking experiments were performed in order to explain their differential
Eduardo Fuentes +6 more
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Discovery of indolylpiperazinylpyrimidines with dual-target profiles at adenosine A2A and dopamine D2 receptors for Parkinson's disease treatment. [PDF]
PLoS ONE, 2018 Parkinson's disease (PD) is a neurodegenerative disorder characterized by progressive loss of dopaminergic neurons in the substantia nigra of the human brain, leading to depletion of dopamine production.
Yi-Ming Shao +13 more
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