Results 1 to 10 of about 34,914 (208)

Supporting the identification of novel fragment-based positive allosteric modulators using a supervised molecular dynamics approach: A retrospective analysis considering the human A2A adenosine receptor as a key example [PDF]

, 2017
Structure-driven fragment-based (SDFB) approaches have provided efficient methods for the identification of novel drug candidates. This strategy has been largely applied in discovering several pharmacological ligand classes, including enzyme inhibitors ...
Deganutti, Giuseppe, Moro, Stefano
core   +3 more sources

Biphasic actions of the adenosine A2a receptor antagonist istradefylline in mice with obstructive uropathy [PDF]

Scientific Reports
Regardless of its underlying causes, progressive chronic kidney disease is characterized by progressive kidney fibrosis. The adenosine A2a receptor is expressed by activated kidney fibroblasts.
Emily S. H. Yeung, Duc Tin Tran, Sri Nagarjun Batchu, Suzanne L. Advani, Youan Liu, Harmandeep Kaur, Darren A. Yuen, Rukhsana Aslam, Cynthia T. Luk, Andrew Advani   +9 more
doaj   +2 more sources

Inhibition of adenosine/A2A receptor signaling suppresses dermal fibrosis by enhancing fatty acid oxidation [PDF]

Cell Communication and Signaling
Background Skin fibrosis presents a major challenge for clinicians treating conditions like systemic sclerosis (SSc) due to its progressive course and limited treatment options.
Xiaoye Zhang, Jinjian Sun, Jia Guo, Xiaoru Hu, Junyu Zhou, Xiaoyun Xie, Xiang Chen, Hui Luo, Hong Liu, Yuzi Tian   +9 more
doaj   +2 more sources

Adenosine-A2A Receptor Pathway in Cancer Immunotherapy. [PDF]

Front Immunol, 2022
Sun C, Wang B, Hao S.
europepmc   +3 more sources

Discovery of a potent, selective, and tumor-suppressing antibody antagonist of adenosine A2A receptor [PDF]

PLoS One
Wang L, Garg P, Chan K, Yuan T, Lujan Hernandez A, Han Z, Peterson S, Tuscano E, Safavi C, Kwan E, Villalta M, Mathur M, Lai J, Axelrod F, Souders C, Emery C, Sato A.   +16 more
europepmc   +3 more sources

Expression of A2A and A2B Adenosine Receptors in Human Breast Tumors

مجله دانشکده پزشکی اصفهان, 2011
Background: The expression profile, signal transduction, molecular function and cell growth modulation of adenosine receptor subtypes in the human breast cancer cell lines are described; we decided to investigate the possible roles of adenosine receptors
Mojtaba Panjehpour, Mohammad Moosavi Nasab   +1 more
doaj   +1 more source

Annexin A2-Mediated Plasminogen Activation in Endothelial Cells Contributes to the Proangiogenic Effect of Adenosine A2A Receptors

Frontiers in Pharmacology, 2021
Adenosine A2A receptor mediates the promotion of wound healing and revascularization of injured tissue, in healthy and animals with impaired wound healing, through a mechanism depending upon tissue plasminogen activator (tPA), a component of the ...
María D. Valls, María Soldado, Jorge Arasa, Jorge Arasa, Miguel Perez-Aso, Adrienne J. Williams, Bruce N. Cronstein, Bruce N. Cronstein, Bruce N. Cronstein, M. Antonia Noguera, M. Antonia Noguera, M. Carmen Terencio, M. Carmen Terencio, M. Carmen Montesinos, M. Carmen Montesinos   +14 more
doaj   +1 more source

A2A adenosine receptor-driven cAMP signaling in olfactory bulb astrocytes is unaffected in experimental autoimmune encephalomyelitis

Frontiers in Immunology, 2023
IntroductionThe cyclic nucleotide cyclic adenosine monophosphate (cAMP) is a ubiquitous second messenger, which is known to play an important anti-inflammatory role.
Marina Wendlandt, Alina J. Kürten, Antonia Beiersdorfer, Charlotte Schubert, Kiana Samad-Yazdtchi, Jessica Sauer, M. Carolina Pinto, Kristina Schulz, Manuel A. Friese, Christine E. Gee, Daniela Hirnet, Christian Lohr   +11 more
doaj   +1 more source

Evidence for coordinated induction and repression of ecto-5'-nucleotidase (CD73) and the A2a adenosine receptor in a human B cell line [PDF]

, 2003
In the human B cell line P493-6 two mitogenic signals, the EpsteinBarr virus nuclear antigen 2 (EBNA2) and myc, can be independently regulated by means of an estrogen receptor fusion construct or an inducible expression vector, respectively.
Burgemeister R., LeHir M., Narravula S., Savic V., Spychala J., Xaus J., Zimmermann H.   +6 more
core   +1 more source

Adenosine A2A Receptor Deletion Blocks the Beneficial Effects of Lactobacillus reuteri in Regulatory T-Deficient Scurfy Mice

Frontiers in Immunology, 2017
The lack of a functional Foxp3 transcription factor and regulatory T (Treg) cells causes lethal, CD4+ T cell-driven autoimmune diseases in scurfy (SF) mice and humans.
Baokun He, Thomas K. Hoang, Dat Q. Tran, Jon Marc Rhoads, Yuying Liu   +4 more
doaj   +1 more source