scRNA‐Seq reveals anti‐lymphoma immune responses in mogamulizumab‐associated skin eruptions
Journal of the European Academy of Dermatology and Venereology, EarlyView.CCR4 was expressed in malignant clones and regulatory T cells in untreated CTCL, that were decreased in MAR. Malignant clones in MAR showed a silenced phenotype with decreases in central memory markers SELL and CCR7, and GTP‐binding member GIMAP7 and upregulation of MMP2 inhibitor TIMP2 and tumour suppressor gene RUNX3.
Shannon Meledathu +13 more
wiley +1 more source
The NLRP3 inflammasome is activated by nanoparticles through ATP, ADP and adenosine.
, 2015 International audienceThe NLR pyrin domain containing 3 (NLRP3) inflammasome is a major component of the innate immune system, but its mechanism of activation by a wide range of molecules remains largely unknown.
Baron, Ludivine +11 more
core +3 more sources
Sex differences in acute and chronic experimental pain models [PDF]
, 2010 Sex differences in response to noxious stimuli and in the development of chronic pain have been increasingly recognized and studied in humans and laboratory animals.
Li, Lili
core +1 more source
Modification of astrocytic Cx43 hemichannel activity in animal models of AD: modulation by adenosine A2A receptors [PDF]
, 2023 Daniela Madeira +5 more
openalex +1 more source
Periodontology 2000, EarlyView.Abstract Peri‐implant diseases are dysbiosis‐mediated inflammatory disorders that occur in susceptible hosts. Antimicrobials and immunomodulatory agents therefore might be pertinent as adjunctive measures in the treatment of such disorders. The aim of this narrative review was to examine the existing evidence and assess the effectiveness of emerging ...
Alberto Monje +3 more
wiley +1 more source
A2A Receptor Antagonism and Dyskinesia in Parkinson’s Disease
Parkinson's Disease, 2012 Dyskinesia, a major complication of treatment of Parkinson’s disease (PD), involves two phases: induction, which is responsible for dyskinesia onset, and expression, which underlies its clinical manifestation.
Micaela Morelli +3 more
doaj +1 more source
Genetic stress echocardiography: role of A2a receptors polymorphism in modulating coronary flow reserve response in non-ischemic dilated cardiomyopathy [PDF]
Background: Vasodilator stress imaging is based on coronary A2a receptor stimulation via endogenous adenosine (with dipyridamole administration), exogenous adenosine, or selective A2a receptor stimulation (with binodenoson).The recognized inter ...
Andreassi, Maria Grazia +8 more
core
Human adenosine A2A receptor : molecular mechanism of ligand binding and activation [PDF]
, 2017 Adenosine receptors (ARs) comprise the P1 class of purinergic receptors and belong to the largest family of integral membrane proteins in the human genome, the G protein-coupled receptors (GPCRs).
Carpenter, Byron, Lebon, Guillaume
core +2 more sources
Glial cells in the heart: Implications for their roles in health and disease
The Journal of Physiology, EarlyView.Abstract figure legend Schematic representation of cardiac autonomic ganglia within epicardial fat pads (posterior heart surface shown), containing vagal postganglionic neuron cell bodies, associated fibres, and glia. These ganglia receive cholinergic input from vagal preganglionic neurons and adrenergic input from sympathetic postganglionic neurons ...
Svetlana Mastitskaya +2 more
wiley +1 more source
Adenosine receptor expression and function in rat striatal cholinergic interneurons [PDF]
, 2000 1. Cholinergic neurons were identified in rat striatal slices by their size, membrane properties, sensitivity to the NK(1) receptor agonist (Sar(9), Met(O(2))(11)) Substance P, and expression of choline acetyltransferase mRNA.
Alistair K Dixon +33 more
core +2 more sources