Results 111 to 120 of about 34,994 (277)

T‐cell exhaustion from a multiomics perspective: Differentiation mechanisms and regulatory networks in the journey from progenitor‐Exhausted T cells to terminally exhausted T cells

Clinical and Translational Medicine, Volume 16, Issue 2, February 2026.
(1) Core Process: Persistent antigen, from TDLNs to TME, drives Tpex → Tex‐int → Tex‐term differentiation. (2) Multiomics Regulation: This fate transition is orchestrated by a co‐ordinated, multi‐layered molecular network. (3) Functional Outcome: Dysregulated signalling and surging co‐inhibitory receptors lock in proliferative arrest and functional ...
Tong Zhu, Xiaoyu Teng, Qinlian Jiao, Yidan Ren, Yunshan Wang, Maoxiao Feng   +5 more
wiley   +1 more source

Adenosine A2a receptor promotes lymphangiogenesis and lymph node metastasis

OncoImmunology, 2019
The formation of new lymphatic vessels, or lymphangiogenesis, is a critical step of the tissue repair program. In pathological conditions involving chronic inflammation or tumorigenesis, this process is often dysregulated and can contribute to disease ...
Bertrand Allard, Isabelle Cousineau, David Allard, Laurence Buisseret, Sandra Pommey, Pavel Chrobak, John Stagg   +6 more
doaj   +1 more source

Static Stretching Acutely Reduces the Ergogenic Effects of Caffeine on Sprint Performance but Not Maximal Ball Velocity in Football Players

European Journal of Sport Science, Volume 26, Issue 2, February 2026.
ABSTRACT This study aimed to investigate the independent and combined effects of caffeine and static stretching (SS) on maximal ball velocity and 30‐m sprint performance. Sixteen male amateur football players performed 30‐m sprint and an instep kicking ball velocity test under six conditions.
Refik Çabuk, İzzet İslamoğlu, Onur Demirarar, Faruk Albay, Yıldırım Kayacan   +4 more
wiley   +1 more source

Adenosine A2A receptor agonist ameliorates EAE and correlates with Th1 cytokine‐induced blood brain barrier dysfunction via suppression of MLCK signaling pathway

Immunity, Inflammation and Disease, 2018
Introduction Multiple sclerosis (MS) disease activity is associated with blood‐brain barrier (BBB) disruption, which is mediated by inflammatory cytokines released by CD4+ lymphocytes.
Ying Liu, Marwan Alahiri, Bianca Ulloa, Boxun Xie, Saud A. Sadiq   +4 more
doaj   +1 more source

The Role Played by Adenosine in Modulating Reflex Sympathetic and Pressor Responses Evoked by Stimulation of TRPV1 in Muscle Afferents

Cellular Physiology and Biochemistry, 2016
Background/Aims: Activation of metabolite-sensitive transient receptor potential vanilloid type 1 (TRPV1) receptors (capsaicin receptors) in afferent nerves of the hindlimb muscles of rats increases renal sympathetic nerve activity (RSNA) and blood ...
Jihong Xing, Jianhua Li
doaj   +1 more source

Neuro‐Immune Crosstalk: Molecular Mechanisms, Biological Functions, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
Neurons, immune cells, and other cellular components within the disease microenvironment (such as stromal cells and tumor cells) constitute a dynamically evolving ecosystem. Neurons directly modulate immune cell activity and inflammatory responses through the release of neurotransmitters (e.g., norepinephrine and CGRP), while also promoting tumor ...
Xin Guo, Hui Liu, Yu‐Jing Song, Jian‐Hua Wang, Danfeng Liu, Zhi‐Wei Zheng, Jia‐Jun Li, Boya Li, An Song, Wei He, Lei‐Lei Yang, Shuo Wang   +11 more
wiley   +1 more source

BDNF-induced presynaptic facilitation of GABAergic transmission in the hippocampus of young adults is dependent of TrkB and adenosine A2A receptors [PDF]

, 2016
Mariana Colino-Oliveira, Diogo M. Rombo, Raquel B. Dias, Joaquim A. Ribeiro, Ana M. Sebastião   +4 more
openalex   +1 more source

Dual Anta-Inhibitors Targeting Protein Kinase CK1δ and A2A Adenosine Receptor Useful in Neurodegenerative Disorders [PDF]

, 2023
Beatrice Francucci, Simone Angeloni, Diego Dal Ben, Catia Lambertucci, Massimo Ricciutelli, Andrea Spinaci, Aleksei N. Smirnov, Rosaria Volpini, Michela Buccioni, Gabriella Marucci   +9 more
openalex   +1 more source

Stabilization versus flexibility: Detergent‐dependent trade‐offs in neurotensin receptor 1 GPCR ensembles

Protein Science, Volume 35, Issue 2, February 2026.
Abstract Detergents provide essential membrane‐mimetic environments for studying G protein‐coupled receptors (GPCRs), but their molecular impact on receptor energetics remains incompletely understood. We combined ligand binding, thermostability measurements, and atomistic molecular dynamics to dissect detergent‐ versus ligand‐driven stabilization in a ...
James B. Bower, Wijnand J. C. van der Velden, Karen P. Gomez, Mingzhe Pan, Fabian Bumbak, Nagarajan Vaidehi, Joshua J. Ziarek   +6 more
wiley   +1 more source

The Effects of Caffeine on Anxiety Behavior in Healthy Individuals: A Systematic Review of the Literature

Stress and Health, Volume 42, Issue 1, February 2026.
ABSTRACT To assess available evidence on the association between anxiety and caffeine consumption in healthy individuals. A high‐sensitivity electronic search was performed, as recommended by the Cochrane Handbook, which underwent peer review according to the PRESS Guide, in March 2021 in the following databases: Cochrane Library, MEDLINE via PUBMED ...
Alef Oliveira do Nascimento, Carlos Emanoel Chaves da Silva, Marianne Lucena da Silva, Katiane da Costa Cunha   +3 more
wiley   +1 more source