Results 11 to 20 of about 61,617 (230)

Adenosine A2a Receptor Polymorphisms and Susceptibility to Anxiety Disorders. [PDF]

Iran J Child Neurol
Keyvanloo Shahrestanaki M, Karami H, Lotfi H, Khorasani M, Babaei Z, Salari Zare M, Kafami M, Abrishami I.   +7 more
europepmc   +3 more sources

Molecular Determinants of CGS21680 Binding to the Human Adenosine A2A Receptor [PDF]

Molecular Pharmacology, 2015
Guillaume Lebon, Patricia C. Edwards, Andrew G. W. Leslie, Christopher G. Tate   +3 more
openalex   +2 more sources

Expression of A2A and A2B Adenosine Receptors in Human Breast Tumors

مجله دانشکده پزشکی اصفهان, 2011
Background: The expression profile, signal transduction, molecular function and cell growth modulation of adenosine receptor subtypes in the human breast cancer cell lines are described; we decided to investigate the possible roles of adenosine receptors
Mojtaba Panjehpour, Mohammad Moosavi Nasab   +1 more
doaj   +1 more source

CRISPR/Cas9 mediated deletion of the adenosine A2A receptor enhances CAR T cell efficacy

Nature Communications, 2021
Adenosine is an immunosuppressive factor that limits anti-tumor immunity through the suppression of multiple immune subsets including T cells via activation of the adenosine A2A receptor (A2AR). Using both murine and human chimeric antigen receptor (CAR)
Lauren Giuffrida, K. Sek, M. Henderson, Junyun Lai, Amanda X. Y. Chen, D. Meyran, Kirsten L Todd, Emma V. Petley, Sherly Mardiana, C. Mølck, Gregory D. Stewart, B. Solomon, I. Parish, P. Neeson, S. Harrison, Lev M. Kats, Imran G. House, P. Darcy, P. Beavis   +18 more
semanticscholar   +1 more source

The Pharmacological Potential of Adenosine A2A Receptor Antagonists for Treating Parkinson’s Disease

Molecules, 2022
The adenosine A2A receptor subtype is recognized as a non-dopaminergic pharmacological target for the treatment of neurodegenerative disorders, notably Parkinson’s disease (PD).
A. Mori, J. Chen, S. Uchida, Cécile Durlach, S. M. King, P. Jenner   +5 more
semanticscholar   +1 more source

Allosteric modulation of the adenosine A2A receptor by cholesterol

bioRxiv, 2021
Cholesterol is a major component of the cell membrane and commonly regulates membrane protein function. Here, we investigate how cholesterol modulates the conformational equilibria and signaling of the adenosine A2A receptor (A2AR) in reconstituted ...
S. K. Huang, Omar Almurad, Reizel J Pejana, Zachary A. Morrison, A. Pandey, Louis-Philippe Picard, M. Nitz, Adnan Sljoka, R. Prosser   +8 more
semanticscholar   +1 more source

Annexin A2-Mediated Plasminogen Activation in Endothelial Cells Contributes to the Proangiogenic Effect of Adenosine A2A Receptors

Frontiers in Pharmacology, 2021
Adenosine A2A receptor mediates the promotion of wound healing and revascularization of injured tissue, in healthy and animals with impaired wound healing, through a mechanism depending upon tissue plasminogen activator (tPA), a component of the ...
María D. Valls, María Soldado, Jorge Arasa, Jorge Arasa, Miguel Perez-Aso, Adrienne J. Williams, Bruce N. Cronstein, Bruce N. Cronstein, Bruce N. Cronstein, M. Antonia Noguera, M. Antonia Noguera, M. Carmen Terencio, M. Carmen Terencio, M. Carmen Montesinos, M. Carmen Montesinos   +14 more
doaj   +1 more source

Pulsed Electromagnetic Fields: A Novel Attractive Therapeutic Opportunity for Neuroprotection After Acute Cerebral Ischemia

Neuromodulation: Technology at the Neural Interface, EarlyView., 2021
Abstract Objectives Acute cerebral ischemia is characterized by several pathological processes evolving during time, which contribute to the final tissue damage. Secondary processes, such as prolonged inflammatory response, impaired mitochondrial function and oxidative stress, are responsible for the progression of brain injury to the peri‐infarct area,
Fioravante Capone, Simona Salati, Fabrizio Vincenzi, Micaela Liberti, Giorgio Aicardi, Francesca Apollonio, Katia Varani, Ruggero Cadossi, Vincenzo Di Lazzaro   +8 more
wiley   +1 more source

A2A adenosine receptor-driven cAMP signaling in olfactory bulb astrocytes is unaffected in experimental autoimmune encephalomyelitis

Frontiers in Immunology, 2023
IntroductionThe cyclic nucleotide cyclic adenosine monophosphate (cAMP) is a ubiquitous second messenger, which is known to play an important anti-inflammatory role.
Marina Wendlandt, Alina J. Kürten, Antonia Beiersdorfer, Charlotte Schubert, Kiana Samad-Yazdtchi, Jessica Sauer, M. Carolina Pinto, Kristina Schulz, Manuel A. Friese, Christine E. Gee, Daniela Hirnet, Christian Lohr   +11 more
doaj   +1 more source

Activation of adenosine A2A receptor by lipids from docosahexaenoic acid revealed by NMR

Science Advances, 2020
NMR studies of A2AAR in lipid bilayers of nanodiscs revealed the mechanism underlying activation of A2AAR by DHA chains. The lipid composition of the plasma membrane is a key parameter in controlling signal transduction through G protein–coupled ...
Takuya Mizumura, Keita Kondo, Masatoshi Kurita, Yutaka Kofuku, Mei Natsume, Shunsuke Imai, Yutaro Shiraishi, Takumi Ueda, I. Shimada   +8 more
semanticscholar   +1 more source