Results 11 to 20 of about 34,994 (277)

Adenosine A2A receptors: localization and function [PDF]

, 2015
Adenosine is an endogenous purine nucleoside present in all mammalian tissues, that originates from the breakdown of ATP. By binding to its four receptor subtypes (A1, A2A, A2B, and A3), adenosine regulates several important physiological functions at ...
A Brand, A Gharib, A Kalhan, A Montinaro, A Mori, A Nishi, A Pinna, A Santos-Rodrigues Dos, A Sato, A Tomaru, AA Link, AE King, AK Dixon, AM Mott, AM Sebastiao, AM Sebastiao, AS Awad, B Sperlagh, B Sperlagh, B Sperlagh, BB Fredholm, BB Fredholm, BB Fredholm, BB Fredholm, BB Fredholm, BB Fredholm, BD Hettinger, C Hammarberg, C Ledent, C Quiroz, C Salgado Garcia, CD Bonan, CM Anderson, CN Wilson, CP Sevigny, D Boison, D Boison, D Boison, D Joel, DC Cassada, DJ Brooks, DJ LaPar, DK Glover, DL Rosin, DL Rosin, DN Bowser, E Dare, E Mazzon, F Ciruela, F Ciruela, F Squadrito, FE Parkinson, G Burnstock, G Burnstock, G Burnstock, G Ghimire, G Haskó, G Schulte, G Schulte, GA Higgins, GE Garcia, GG Yegutkin, GM Halliday, GW Sullivan, H Kobayashi, H Zimmermann, HJ Groenewegen, I Feoktistov, J Espinosa, J Fastbom, J Kang, J Snel, J Tchekalarova, JA Ribeiro, JF Chen, JF Chen, JG Dobson Jr, JM Dickenson, JP Headrick, JR Fozard, JS Fink, K Biber, K Fuxe, K Yamada, KD Pierce, L Antonioli, L Antonioli, L Antonioli, L Belardinelli, L Wells, LC Rump, LP Shearman, M Canals, M Fornai, M Katebi, M Kawamura Jr, M Kurokawa, M Kurokawa, M Lazarus, M Matos, M Matos, M Milanese, M Morelli, M Morelli, M Odashima, M O’Neill, M Pouliot, M Reddington, M Schindler, M Storr, MA Ruiz, MA Schwarzschild, MA Souza, MA Trevethick, MC Wittendorp, MD Desrosiers, MD Okusa, MF Jarvis, MJ Bours, MJ Hussey, MJ Wall, MP Abbracchio, MP Abbracchio, MS Hershfield, N Ates, N Cabello, N Levens, N Rebola, N Rebola, N Simola, O Bonneau, O Cauli, O Pascual, P Carriba, P Carriba, P Popoli, P Popoli, P Svenningsson, P Svenningsson, P Svenningsson, P Svenningsson, P Voorn, PA LeWitt, PJ Gebicke-Haerter, R Rahimian, RA Cunha, RA Cunha, RA Cunha, RD Prediger, RH Al-Mashhadi, RJ Rodrigues, S Ferre, S Ferré, S Ferré, S Ferré, S Ferré, S James, S Latini, S Latini, S Revan, SA Baldwin, SA Hunsucker, SA Rivkees, SA Rivkees, SG Khasar, SJ Augood, SJ Brown, SM Duffy, SN Schiffmann, SN Schiffmann, SP Alexander, SW Schoen, T Eckle, T Kadowaki Horita, T Ochiishi, T Othman, TC Bingham, TF Wang, TH Adair, TV Dunwiddie, TV Dunwiddie, V Ralevic, W Hauber, Y Mizuno, Y Pankratov, Y Pankratov, Y Zhong, Z Díaz-Cabiale, Z Justinova, Z Kovacs, Z Selmeczy   +190 more
core   +3 more sources

Adenosine A2A receptor activation reduces chondrocyte senescence. [PDF]

FASEB J, 2023
Abstract Osteoarthritis (OA) pathogenesis is associated with reduced chondrocyte homeostasis and increased levels of cartilage cellular senescence. Chondrosenescence is the development of cartilage senescence that increases with aging joints and disrupts chondrocyte homeostasis and is associated with OA.
Friedman B, Larranaga-Vera A, Castro CM, Corciulo C, Rabbani P, Cronstein BN.   +5 more
europepmc   +3 more sources

Adenosine A2a receptor in Experimental Periodontitis

Dentistry Review
OBJECTIVES: Our previous work has shown the role of adenosine in mitochondrial health to regulate IL-1-mediated inflammation in human gingival fibroblasts, and the protective role of enzyme CD73, which is the final step to generate adenosine ...
Nathalie Paladines, Ana Carolina Morandini, DDS MDS PhD   +1 more
doaj   +2 more sources

Pulsed Electromagnetic Fields: A Novel Attractive Therapeutic Opportunity for Neuroprotection After Acute Cerebral Ischemia

Neuromodulation: Technology at the Neural Interface, EarlyView., 2021
Abstract Objectives Acute cerebral ischemia is characterized by several pathological processes evolving during time, which contribute to the final tissue damage. Secondary processes, such as prolonged inflammatory response, impaired mitochondrial function and oxidative stress, are responsible for the progression of brain injury to the peri‐infarct area,
Fioravante Capone, Simona Salati, Fabrizio Vincenzi, Micaela Liberti, Giorgio Aicardi, Francesca Apollonio, Katia Varani, Ruggero Cadossi, Vincenzo Di Lazzaro   +8 more
wiley   +1 more source

Synergistic Effects of Adenosine A2A Antagonist and L-DOPA on Rotational Behaviors in 6-Hydroxydopamine-Induced Hemi-Parkinsonian Mouse Model

Journal of Pharmacological Sciences, 2007
In this study, we examined the combination effects of L-DOPA and adenosine receptor antagonists on rotational behaviors in a hemi-Parkinsonian mouse model induced by unilateral 6-hydroxydopamine (6-OHDA) injection. The adenosine A2A antagonist SCH-58261,
Takahiro Matsuya, Kazuhiro Takuma, Kosuke Sato, Makoto Asai, Yoshihiro Murakami, Sosuke Miyoshi, Akihiro Noda, Taku Nagai, Hiroyuki Mizoguchi, Shintaro Nishimura, Kiyofumi Yamada   +10 more
doaj   +1 more source

CD73-A2a adenosine receptor axis promotes innate B cell antibody responses to pneumococcal polysaccharide vaccination. [PDF]

PLoS ONE, 2018
Many individuals at risk of streptococcal infection respond poorly to the pneumococcal polysaccharide vaccine Pneumovax 23. Identification of actionable pathways able to enhance Pneumovax responsiveness is highly relevant.
David Allard, Roxanne Charlebois, Loise Gilbert, John Stagg, Pavel Chrobak   +4 more
doaj   +1 more source

Activation of adenosine A2A receptors induces TrkB translocation and increases BDNF-mediated phospho-TrkB localization in lipid rafts : implications for neuromodulation [PDF]

, 2010
Copyright © 2010 the authorsBrain-derived neurotrophic factor (BDNF) signaling is critical for neuronal development and transmission. Recruitment of TrkB receptors to lipid rafts has been hown to be necessary for the activation of specific signaling ...
Assaife-Lopes, Natália, Chao, Moses V., Pereira, Daniela B., Ribeiro, Joaquim A., Sebastião, Ana M, Sousa, Vasco C.   +5 more
core   +1 more source

Adenosine A_2A receptor binding profile of two antagonists, ST1535 and KW6002: consideration on the presence of atypical adenosine A_2A binding sites

Frontiers in Psychiatry, 2010
Adenosine A2A receptors seem to exist in typical (more in striatum) and atypical (more in hippocampus and cortex) subtypes. In the present study, we investigated the affinity of two adenosine A2A receptor antagonists, ST1535 [2 butyl -9-methyl-8-(2H-1,2 ...
Teresa Riccioni, Fabiana Leonardi, Franco Borsini   +2 more
doaj   +1 more source

ST 1535: a preferential A2A adenosine receptor antagonist [PDF]

The International Journal of Neuropsychopharmacology, 2005
Antagonism of the A2A adenosine function has proved beneficial in the treatment of Parkinson's disease, in that it increases L-dopa therapeutical effects without concomitant worsening of its side-effects. In this paper we describe a preferential A2A adenosine antagonist, ST 1535, with long-lasting pharmacodynamic effects.
Maria Antonietta Stasi, Franco Borsini, Katia Varani, Fabrizio Vincenzi, M. Assunta Di Cesare, Patrizia Minetti, Orlando Ghirardi, Paolo Carminati   +7 more
openalex   +4 more sources

Adenosine Receptors and Wound Healing

The Scientific World Journal, 2004
Recent studies have demonstrated that application of topical adenosine A2A receptor agonists promotes more rapid wound closure and clinical studies are currently underway to determine the utility of topical A2A adenosine receptor agonists in the therapy ...
Bruce N. Cronstein
doaj   +1 more source