Results 191 to 200 of about 61,617 (230)

Adenosine A_2A receptor as a potential regulator of Mycobacterium leprae survival mechanisms: new insights into leprosy neural damage. [PDF]

Front Pharmacol
Dos Santos PMF, Díaz Acosta CC, Rosa TLSA, Ishiba MH, Dias AA, Pereira AMR, Gutierres LD, Pereira MP, da Silva Rocha M, Rosa PS, Bertoluci DFF, Meyer-Fernandes JR, da Mota Ramalho Costa F, Marques MAM, Belisle JT, Pinheiro RO, Rodrigues LS, Pessolani MCV, Berrêdo-Pinho M.   +18 more
europepmc   +1 more source

Physiology and pathophysiology of central adenosine A1 and A2A receptors

, 2003
Linda Henriksson
openalex  

Radiosynthesis and In Vitro Evaluation of [¹¹C]tozadenant as Adenosine A_2A Receptor Radioligand. [PDF]

Molecules
Humpert S, Schneider D, Lang M, Schulze A, Neumaier F, Holschbach M, Bier D, Neumaier B.   +7 more
europepmc   +1 more source

Caffeine's Neuroprotective Effect on Memory Impairment: Suppression of Adenosine A₂A Receptor and Enhancement of Tyrosine Hydroxylase in Dopaminergic Neurons Under Hypobaric Hypoxia Conditions. [PDF]

CNS Neurosci Ther
Zhong Z, Dong H, Zhou S, Lin C, Huang P, Li X, Zhang J, Xie J, Wu Y, Li P.   +9 more
europepmc   +1 more source

Minute-timescale free-energy calculations reveal a pseudo-active state in the adenosine A_2A receptor activation mechanism.

Chem
D'Amore VM, Conflitti P, Marinelli L, Limongelli V.   +3 more
europepmc   +1 more source

Adenosine A_2A receptor-mediated interactions between Th1⁺ T cells and the choroid plexus epithelium via IFN-γ signalling control T-Cell infiltration in experimental autoimmune encephalomyelitis. [PDF]

Cell Commun Signal
Qi C, Yang Y, Tang P, Zheng C, Li X, Jiang N, Qu J, Chen JF, Zheng W.   +8 more
europepmc   +1 more source

Nociceptive adenosine A_2A receptor on trigeminal nerves orchestrates CGRP release to regulate the progression of oral squamous cell carcinoma. [PDF]

Int J Oral Sci
Jiang L, Zhou Y, Tang S, Yang D, Zhang Y, Zhang J, Yang F, Zhou T, Xia X, Chen Q, Jiang L, Jiang Y, Feng X.   +12 more
europepmc   +1 more source

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Adenosine A2A Receptor Antagonists for Cancer Immunotherapy.

Journal of Medicinal Chemistry, 2020
Currently, the most promising therapeutic modality for cancer treatment is the blockade of immune checkpoint pathways, which has revolutionized cancer therapy in the last 15 years.
Fazhi Yu, Chenyu Zhu, Qiong Xie, Yonghui Wang   +3 more
semanticscholar   +1 more source

Targeting adenosine A2A receptor antagonism for treatment of cancer

Expert Opinion on Drug Discovery, 2018
Introduction: Adenosine A2A Receptor (A2AR) antagonists are an emerging class of agents that treat cancers, both as a monotherapy and in combination with other therapeutic agents. Several studies support the accumulation of extracellular adenosine in the
M. Congreve, Giles A. Brown, A. Borodovsky, M. Lamb   +3 more
semanticscholar   +1 more source