Results 231 to 240 of about 34,994 (277)

Radiosynthesis and In Vitro Evaluation of [¹¹C]tozadenant as Adenosine A_2A Receptor Radioligand. [PDF]

Molecules
Humpert S, Schneider D, Lang M, Schulze A, Neumaier F, Holschbach M, Bier D, Neumaier B.   +7 more
europepmc   +1 more source

Adenosine A_2A receptor as a potential regulator of Mycobacterium leprae survival mechanisms: new insights into leprosy neural damage. [PDF]

Front Pharmacol
Dos Santos PMF, Díaz Acosta CC, Rosa TLSA, Ishiba MH, Dias AA, Pereira AMR, Gutierres LD, Pereira MP, da Silva Rocha M, Rosa PS, Bertoluci DFF, Meyer-Fernandes JR, da Mota Ramalho Costa F, Marques MAM, Belisle JT, Pinheiro RO, Rodrigues LS, Pessolani MCV, Berrêdo-Pinho M.   +18 more
europepmc   +1 more source

Minute-timescale free-energy calculations reveal a pseudo-active state in the adenosine A_2A receptor activation mechanism.

Chem
D'Amore VM, Conflitti P, Marinelli L, Limongelli V.   +3 more
europepmc   +1 more source

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Adenosine A2A receptors and sleep

2023
Adenosine, a known endogenous somnogen, induces sleep via A1 and A2A receptors. In this chapter, we review the current knowledge regarding the role of the adenosine A2A receptor and its agonists, antagonists, and allosteric modulators in sleep-wake regulation.
Mustafa, Korkutata, Michael, Lazarus
openaire   +2 more sources

Pharmacology of adenosine A2A receptors

Trends in Pharmacological Sciences, 1996
Adenosine A2A receptors, which have been cloned from several mammalian species, are activated by physiological concentrations of adenosine to stimulate the formation of cAMP and other mediators. The A2A receptors are found on neutrophil leukocytes, platelets, blood vessels and, very abundantly, on some cells in the CNS.
E, Ongini, B B, Fredholm
openaire   +3 more sources

Adenosine A2A receptor and glia

2023
The adenosine A2A receptor (A2AR) is abundantly expressed in the brain, including both neurons and glial cells. While the expression of A2AR is relative low in glia, its levels elevate robustly in astrocytes and microglia under pathological conditions.
openaire   +2 more sources

Adenosine A2A Receptors and Parkinson’s Disease

2009
The drug treatment of Parkinson's disease (PD) is accompanied by a loss of drug efficacy, the onset of motor complications, lack of effect on non-motor symptoms, and a failure to modify disease progression. As a consequence, novel approaches to therapy are sought, and adenosine A(2A) receptors (A(2A)ARs) provide a viable target.
MORELLI, MICAELA, CARTA, ANNAROSA, JENNER P.   +2 more
openaire   +3 more sources

Adenosine receptor modelling. A1/A2a selectivity

European Journal of Medicinal Chemistry, 2006
Three-dimensional models of the A(1) and A(2a) adenosine receptors (AR) were constructed by means of a homology procedure, using bovine rhodopsin as a template. In order to validate the two models, a docking analysis of selective agonists was carried out.
TUCCINARDI, TIZIANO, ORTORE, GABRIELLA MARIA PIA, MANERA, CLEMENTINA, SACCOMANNI, GIUSEPPE, MARTINELLI, ADRIANO   +4 more
openaire   +3 more sources

Neuropharmacology of the adenosine A2A receptors

Drug Development Research, 1996
Studies done over the last 20 years have clearly shown that the adenosine A 2A receptors are abundant in the striatum of several animal species. A 2A receptors have also been found in the cerebral cortex and hippocampus. The distribution of A 2A receptors closely matches that of dopamine D 2 receptors, being expressed in striatopallidal GABAergic ...
ONGINI E, DIONISOTTI S, MORELLI, MICAELA, FERRE S, SVENNINGSSON P, FUXE K, FREDHOLM B.   +6 more
openaire   +2 more sources

Selective adenosine A2A receptor antagonists

Il Farmaco, 2001
In the early 1990s it became clear that the A2A adenosine receptor had characteristics that made it distinct from the other A1, A2B and A3 adenosine receptors. Great progress has been made with the discovery of selective A2A receptor antagonists. A variety of synthetic substitutions on the xanthine moiety led the chemists of Kyowa-Hakko to discover ...
BARALDI, Pier Giovanni, MONOPOLI A, CACCIARI, Barbara, BARALDI PG   +3 more
openaire   +2 more sources