Results 31 to 40 of about 61,617 (230)

Adenosine A2A Receptor Modulates the Activity of Globus Pallidus Neurons in Rats

Frontiers in Physiology, 2017
The globus pallidus is a central nucleus in the basal ganglia motor control circuit. Morphological studies have revealed the expression of adenosine A2A receptors in the globus pallidus.
Hui-Ling Diao, Hui-Ling Diao, Yan Xue, Xiao-Hua Han, Shuang-Yan Wang, Shuang-Yan Wang, Cui Liu, Wen-Fang Chen, Lei Chen   +8 more
doaj   +1 more source

Evidence for Arrhythmogenic Effects of A2A-Adenosine Receptors

Frontiers in Pharmacology, 2019
Adenosine can be released from the heart and may stimulate four different cardiac adenosine receptors. A receptor subtype that couples to the generation of cyclic adenosine monophosphate (cAMP) is the A2A-adenosine receptor (A2A-AR). To better understand
Peter Boknik, Katharina Drzewiecki, John Eskandar, Ulrich Gergs, Britt Hofmann, Hendrik Treede, Stephanie Grote-Wessels, Larissa Fabritz, Larissa Fabritz, Paulus Kirchhof, Paulus Kirchhof, Paulus Kirchhof, Lisa Fortmüller, Frank Ulrich Müller, Wilhelm Schmitz, Norbert Zimmermann, Uwe Kirchhefer, Joachim Neumann   +17 more
doaj   +1 more source

Cryo-EM structure of the adenosine A2A receptor coupled to an engineered heterotrimeric G protein

bioRxiv, 2018
The adenosine A2A receptor (A2AR) is a prototypical G protein-coupled receptor (GPCR) that couples to the heterotrimeric G protein GS. Here we determine the structure by electron cryo-microscopy (cryo-EM) of A2AR at pH 7.5 bound to the small molecule ...
J. García-Nafría, Yang Lee, X. Bai, B. Carpenter, C. Tate   +4 more
semanticscholar   +1 more source

The Adenosine A2A Receptor Agonist Accelerates Bone Healing and Adjusts Treg/Th17 Cell Balance through Interleukin 6

BioMed Research International, 2020
The aim of this study was to explore the effect of adenosine A2A receptor agonists on fracture healing and the regulation of the immunity system after bone fracture. We implanted fibrin gel containing adenosine A2A receptor agonist CGS 21680/inhibitor ZM
Xi Zheng, Dong Wang
semanticscholar   +1 more source

Adenosine A2A Receptor Blockade Modulates Glucocorticoid-Induced Morphological Alterations in Axons, But Not in Dendrites, of Hippocampal Neurons

Frontiers in Pharmacology, 2018
The exposure to supra-physiological levels of glucocorticoids in prenatal life can lead to a long-term impact in brain cytoarchitecture, increasing the susceptibility to neuropsychiatric disorders.
Helena Pinheiro, Helena Pinheiro, Rita Gaspar, Rita Gaspar, Filipa I. Baptista, Filipa I. Baptista, Carlos A. Fontes-Ribeiro, Carlos A. Fontes-Ribeiro, Carlos A. Fontes-Ribeiro, António F. Ambrósio, António F. Ambrósio, António F. Ambrósio, Catarina A. Gomes, Catarina A. Gomes, Catarina A. Gomes   +14 more
doaj   +1 more source

A2A Adenosine Receptor Antagonism Reverts the Blood-Brain Barrier Dysfunction Induced by Sleep Restriction. [PDF]

PLoS ONE, 2016
Chronic sleep restriction induces blood-brain barrier disruption and increases pro-inflammatory mediators in rodents. Those inflammatory mediators may modulate the blood-brain barrier and constitute a link between sleep loss and blood-brain barrier ...
Gabriela Hurtado-Alvarado, Emilio Domínguez-Salazar, Javier Velázquez-Moctezuma, Beatriz Gómez-González   +3 more
doaj   +1 more source

Adenosine A2A Receptor Blockade as an Immunotherapy for Treatment-Refractory Renal Cell Cancer.

Cancer Discovery, 2019
Adenosine mediates immunosuppression within the tumor microenvironment through triggering adenosine 2A receptors (A2AR) on immune cells. To determine whether this pathway could be targeted as an immunotherapy, we performed a phase 1 clinical trial with a
L. Fong, A. Hotson, J. Powderly, M. Sznol, R. Heist, T. Choueiri, S. George, B. Hughes, M. Hellmann, D. Shepard, B. Rini, S. Kummar, A. Weise, Matthew J. Riese, B. Markman, L. Emens, D. Mahadevan, J. Luke, G. Laport, J. Brody, L. Hernandez-Aya, P. Bonomi, J. Goldman, L. Berim, D. Renouf, R. Goodwin, Brian Munneke, P. Ho, J. Hsieh, I. McCaffery, L. Kwei, S. Willingham, Richard A. Miller   +32 more
semanticscholar   +1 more source

Involvement of Adenosine A2a Receptor in Intraocular Pressure Decrease Induced by 2-(1-Octyn-1-yl)adenosine or 2-(6-Cyano-1-hexyn-1-yl)adenosine

Journal of Pharmacological Sciences, 2005
The aim of the present study is to clarify the mechanism for the decrease in intraocular pressure by 2-alkynyladenosine derivatives in rabbits. The receptor binding analysis revealed that 2-(1-octyn-1-yl)adenosine (2-O-Ado) and 2-(6-cyano-1-hexyn-1-yl ...
Takashi Konno, Akira Murakami, Takehiro Uchibori, Akihiko Nagai, Kentaro Kogi, Norimichi Nakahata   +5 more
doaj   +1 more source

Phenotyping of Mice with Heart Specific Overexpression of A2A-Adenosine Receptors: Evidence for Cardioprotective Effects of A2A-Adenosine Receptors

Frontiers in Pharmacology, 2018
Background: Adenosine can be produced in the heart and acts on cardiac adenosine receptors. One of these receptors is the A2A-adenosine receptor (A2A-AR).Methods and Results: To better understand its role in cardiac function, we generated and ...
Peter Boknik, Katharina Drzewiecki, John Eskandar, Ulrich Gergs, Stephanie Grote-Wessels, Larissa Fabritz, Paulus Kirchhof, Frank U. Müller, Frank Stümpel, Wilhelm Schmitz, Norbert Zimmermann, Uwe Kirchhefer, Joachim Neumann   +12 more
doaj   +1 more source

Adenosine A2a Receptor Regulates Autophagy Flux and Apoptosis to Alleviate Ischemia-Reperfusion Injury via the cAMP/PKA Signaling Pathway

Frontiers in Cardiovascular Medicine, 2022
Exploring effective methods to lessen myocardial ischemia-reperfusion injury still has positive significance. The adenosine A2a receptor (A2aR) has played a crucial part in cardiac ischemia-reperfusion injury. Previous studies revealed that the adenosine
Yun Xia, Feng He, Mohamed Bassirou Moukeila Yacouba, Huimin Zhou, Jingfan Li, Ying Xiong, Jingjing Zhang, Hui Li, Yanlin Wang, Jianjuan Ke   +9 more
doaj   +1 more source