Results 41 to 50 of about 34,994 (277)

Adenosine A2A receptor agonists with potent antiplatelet activity

Platelets, 2018
Selected adenosine A2A receptor agonists (PSB-15826, PSB-12404, and PSB-16301) have been evaluated as new antiplatelet agents. In addition, radioligand-binding studies and receptor-docking experiments were performed in order to explain their differential
Eduardo Fuentes, Manuel Fuentes, Julio Caballero, Iván Palomo, Sonja Hinz, Ali El-Tayeb, Christa E. Müller   +6 more
doaj   +1 more source

Inhibition of platelet activation and thrombus formation by adenosine and inosine: studies on their relative contribution and molecular modeling. [PDF]

PLoS ONE, 2014
The inhibitory effect of adenosine on platelet aggregation is abrogated after the addition of adenosine-deaminase. Inosine is a naturally occurring nucleoside degraded from adenosine.The mechanisms of antiplatelet action of adenosine and inosine in vitro
Eduardo Fuentes, Jaime Pereira, Diego Mezzano, Marcelo Alarcón, Julio Caballero, Iván Palomo   +5 more
doaj   +1 more source

Adenosine A2A Receptor: A New Neuroprotective Target in Light-Induced Retinal Degeneration

Frontiers in Pharmacology, 2022
Continuous illumination induces the degeneration of photoreceptors. This animal model of light-induced retinal degeneration resembles many characteristics of human degenerative diseases of the outer retina, such as age-related macular degeneration.
Manuel Soliño, Ignacio M. Larrayoz, Ester María López, Manuel Rey-Funes, Mariana Bareiro, Cesar Fabián Loidl, Elena Girardi, Alfredo Martínez, Juan José López-Costa   +8 more
doaj   +1 more source

Dystonia: sparse synapses for D2 receptors in striatum of a DYT1 knock-out mouse model [PDF]

, 2020
Dystonia pathophysiology has been partly linked to downregulation and dysfunction of dopamine D2 receptors in striatum. We aimed to investigate the possible morpho-structural correlates of D2 receptor downregulation in the striatum of a DYT1 Tor1a mouse ...
Biagioni, S., Cardarelli, S., D'angelo, V., Fusco, F. R., Giorgi, M., Mercuri, N. B., Paldino, E., Sancesario, G., Sorge, R.   +8 more
core   +1 more source

Adenosine A2A receptor deficiency up-regulates cystatin F expression in white matter lesions induced by chronic cerebral hypoperfusion. [PDF]

PLoS ONE, 2012
In previous studies, we have shown that the inactivation of the adenosine A2A receptor exacerbates chronic cerebral hypoperfusion-induced white matter lesions (WMLs) by enhancing neuroinflammatory responses.
Wei Duan, Hong Ran, Zhujuan Zhou, Qifen He, Jian Zheng   +4 more
doaj   +1 more source

Adenosine A2A receptors and basal ganglia physiology [PDF]

Progress in Neurobiology, 2007
Adenosine A2A receptors are highly enriched in the basal ganglia system. They are predominantly expressed in enkephalin-expressing GABAergic striatopallidal neurons and therefore are highly relevant to the function of the indirect efferent pathway of the basal ganglia system.
Schiffmann,SN, Fisone,G, MORESCO, ROSA MARIA, Cunha, RA, Ferrè,S   +4 more
openaire   +5 more sources

Randomized phase 2 trial of regadenoson for treatment of acute vaso-occlusive crises in sickle cell disease [PDF]

, 2017
Key Points Regadenoson did not reduce iNKT cell activation to a prespecified level when administered to patients with SCD. Because iNKT cell activation was not reduced, the benefit of iNKT cell-based therapies in SCD cannot be determined.
Achebe, Maureen, Chu, Hillary, Field, Joshua J., George, Alex, Gordeuk, Victor R., Gowhari, Michel, Heeney, Matthew M., Hoppe, Carolyn, Lin, Gene, Linden, Joel, Majerus, Elaine, Nathan, David G., Neuberg, Donna, Puligandla, Maneka, Sheehan, Brian   +14 more
core   +2 more sources

Characterization of the trigeminovascular actions of several adenosine A2A receptor antagonists in an in vivo rat model of migraine

The Journal of Headache and Pain, 2018
Background Migraine is considered a neurovascular disorder, but its pathophysiological mechanisms are not yet fully understood. Adenosine has been shown to increase in plasma during migraine attacks and to induce vasodilation in several blood vessels ...
Kristian A. Haanes, Alejandro Labastida-Ramírez, Kayi Y. Chan, René de Vries, Brian Shook, Paul Jackson, Jimmy Zhang, Christopher M. Flores, Alexander H. J. Danser, Carlos M. Villalón, Antoinette MaassenVanDenBrink   +10 more
doaj   +1 more source

Adenosine A2A receptor modulation of hippocampal CA3-CA1 synapse plasticity during associative learning in behaving mice [PDF]

, 2009
© 2009 Nature Publishing Group All rights reservedPrevious in vitro studies have characterized the electrophysiological and molecular signaling pathways of adenosine tonic modulation on long-lasting synaptic plasticity events, particularly for
A de Mendonça, A de Mendonça, A Gruart, A Gruart, A Monopoli, Agnès Gruart, AM Sebastião, AM Thomson, Ana M Sebastião, BM Fontinha, Bruno M Fontinha, C Zocchi, CC Fernandes, CD Woody, CS Rex, DKJE von Lubitz, E Dominguez-del-Toro, E Porras-García, ER Kandel, F Engert, F Suzuki, FS Lee, G Burnstock, G Neves, G Paxinos, GG Turrigiano, HJ Normile, I Gureviciene, I Sahún, JA Ribeiro, JE Kelsey, JM Delgado-Garcia, Joaquim A Ribeiro, José M Delgado-García, JR Whitlock, K Kessey, K Kessey, K Takatsuki, L Boulanger, L Connole, L Winsky, M de Jonge, M El Yacoubi, M El Yacoubi, M Ohno, M Yang, MJ Diógenes, MJ Diógenes, MT Tebano, MT Tebano, N Madroñal, N Rebola, Noelia Madroñal, O Dall'Igna, PA Schwartzkroin, RF Thompson, RS Zucker, S Ferré, S Maren, S Mingote, SR Kopf, T Sakamoto, TV Bliss, TVP Bliss, W Tseng, Y Kishimoto, Y Kishimoto, Y Sekino, Y Wang   +68 more
core   +1 more source

Targeting Post‐Irradiation Thyroid Dysfunction: Electrospun Scaffolds As A Dual‐Action Approach for Antioxidant and Immune Modulation

Advanced Healthcare Materials, EarlyView.
Radiation‐induced hypothyroidism follows head and neck radiotherapy due to oxidative stress and inflammation. Electrospun polycaprolactone scaffolds containing adenosine have potential to modulate thyroid repair. Scaffolds enhance thyrocyte proliferation, antioxidant enzymes glutathione peroxidase and catalase, reduce senescence and apoptosis markers ...
Maria Heim, Ella‐Louise Handley, Daniel Grant, Lizi M. Hegarty, Elaine Emmerson, Anthony Callanan   +5 more
wiley   +1 more source