Results 61 to 70 of about 61,617 (230)

Adenosine A2A Receptor Antagonists in Neurodegenerative Diseases: Huge Potential and Huge Challenges

Frontiers in Psychiatry, 2018
In this opinion paper, we provide scientific-based reasons about the huge therapeutic potential of adenosine A2A receptor antagonists, and about the huge challenges to demonstrate efficacy in clinical trials, i.e., to provide data now required to approve
R. Franco, Gemma Navarro
semanticscholar   +1 more source

scRNA‐Seq reveals anti‐lymphoma immune responses in mogamulizumab‐associated skin eruptions

Journal of the European Academy of Dermatology and Venereology, EarlyView.
CCR4 was expressed in malignant clones and regulatory T cells in untreated CTCL, that were decreased in MAR. Malignant clones in MAR showed a silenced phenotype with decreases in central memory markers SELL and CCR7, and GTP‐binding member GIMAP7 and upregulation of MMP2 inhibitor TIMP2 and tumour suppressor gene RUNX3.
Shannon Meledathu, Agata Kurowski, Malini P. Naidu, Jonas Adalsteinsson, Shane A. Meehan, Natalia Alkon, Lauren R. Port, Sumanth Chennareddy, Emry R. Cohenour, Grace Christensen, Jonah Shulman, Nicholas Gulati, Constanze Jonak, Patrick M. Brunner   +13 more
wiley   +1 more source

LASSBio-897 Reduces Lung Injury Induced by Silica Particles in Mice: Potential Interaction with the A2A Receptor

Frontiers in Pharmacology, 2017
Silicosis is a lethal fibro-granulomatous pulmonary disease highly prevalent in developing countries, for which no proper therapy is available. Among a small series of N-acylhydrazones, the safrole-derived compound LASSBio-897 (3-thienylidene-3, 4 ...
Vinicius F. Carvalho, Tatiana P. T. Ferreira, Ana C. S. de Arantes, François Noël, François Noël, Roberta Tesch, Roberta Tesch, Carlos M. R. Sant’Anna, Eliezer J. L. Barreiro, Eliezer J. L. Barreiro, Carlos A. M. Fraga, Patrícia M. Rodrigues e Silva, Patrícia M. Rodrigues e Silva, Marco A. Martins, Marco A. Martins   +14 more
doaj   +1 more source

Cognitive changes mediated by adenosine receptor blockade in a resveratrol-treated atherosclerosis-prone lupus mouse model

Journal of Traditional and Complementary Medicine, 2022
Background and aim: Resveratrol is a bioactive molecule used in dietary supplements and herbal medicines and consumed worldwide. Prior work showed that resveratrol's anti-atherogenic properties are mediated in part through the adenosine A2A receptor. The
Lora J. Kasselman, Heather A. Renna, Iryna Voloshyna, Aaron Pinkhasov, Irving H. Gomolin, Isaac Teboul, Joshua De Leon, Steven E. Carsons, Allison B. Reiss   +8 more
doaj   +1 more source

Adenosine A2A receptor ligand recognition and signaling is blocked by A2B receptors

OncoTarget, 2018
The adenosine receptor (AR) subtypes A2A and A2B are rhodopsin-like Gs protein-coupled receptors whose expression is highly regulated under pathological, e.g. hypoxic, ischemic and inflammatory conditions.
Sonja Hinz, Gemma Navarro, D. Borroto-Escuela, Benjamin F. Seibt, York-Christoph Ammon, Elisabetta de Filippo, A. Danish, Svenja K. Lacher, Barbora Červinková, Muhammad Rafehi, K. Fuxe, A. Schiedel, R. Franco, C. Müller   +13 more
semanticscholar   +1 more source

Administration of the Sleep‐Promoting Neuromodulator Adenosine Into the Median Preoptic and Septal Region Produced Thermal Hyperalgesia

Journal of Sleep Research, EarlyView.
ABSTRACT Abundant clinical and preclinical evidence demonstrates that sleep and pain have bidirectional interactions. Sleep loss enhances pain perception and pain disrupts sleep. However, the exact neurobiological mechanisms through which sleep loss alters pain remain poorly understood.
Viviane S. Hambrecht‐Wiedbusch, Angelo V. Colmenero, Alejandra Mondino, Graciela Mentz, Steven E. Harte, Giancarlo Vanini   +5 more
wiley   +1 more source

The Role of Adenosine Signaling in Headache: A Review

Brain Sciences, 2017
Migraine is the third most prevalent disease on the planet, yet our understanding of its mechanisms and pathophysiology is surprisingly incomplete. Recent studies have built upon decades of evidence that adenosine, a purine nucleoside that can act as a ...
Nathan T. Fried, Melanie B. Elliott, Michael L. Oshinsky   +2 more
doaj   +1 more source

Emerging locally delivered antimicrobial and immunomodulatory approaches for the prevention/treatment of peri‐implant diseases

Periodontology 2000, EarlyView.
Abstract Peri‐implant diseases are dysbiosis‐mediated inflammatory disorders that occur in susceptible hosts. Antimicrobials and immunomodulatory agents therefore might be pertinent as adjunctive measures in the treatment of such disorders. The aim of this narrative review was to examine the existing evidence and assess the effectiveness of emerging ...
Alberto Monje, Ettore Amerio, Irene Mallor, Conrado Aparicio   +3 more
wiley   +1 more source

An Affinity-Based Probe for the Human Adenosine A2A Receptor

Journal of Medicinal Chemistry, 2018
Using activity-based protein profiling (ABPP), functional proteins can be interrogated in their native environment. Despite their pharmaceutical relevance, G protein-coupled receptors (GPCRs) have been difficult to address through ABPP.
Xue Yang, T. Michiels, C. D. de Jong, Marjolein Soethoudt, N. Dekker, E. Gordon, Mario van der Stelt, L. Heitman, Daan van der Es, A. IJzerman   +9 more
semanticscholar   +1 more source

Glial cells in the heart: Implications for their roles in health and disease

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic representation of cardiac autonomic ganglia within epicardial fat pads (posterior heart surface shown), containing vagal postganglionic neuron cell bodies, associated fibres, and glia. These ganglia receive cholinergic input from vagal preganglionic neurons and adrenergic input from sympathetic postganglionic neurons ...
Svetlana Mastitskaya, Rimma Dugarova, Shefeeq M. Theparambil   +2 more
wiley   +1 more source