Results 71 to 80 of about 61,617 (230)
Treatment Options for Motor Fluctuations in Parkinson's Disease
Movement Disorders, EarlyView.
Günter Höglinger +3 more
wiley +1 more source
Astrocytes: Orchestrators of brain gas exchange and oxygen homeostasis
The Journal of Physiology, EarlyView.Abstract figure legend Oxygen and carbon dioxide enter the body via breathing; in the brain astrocytes play a key role balancing oxygen delivery with carbon dioxide removal. Abstract If we consider neurons like muscles during exercise, the demand for oxygen (O2) and carbon dioxide (CO2) elimination is constantly changing.
Isabel N. Christie
wiley +1 more source
Targeting Adenosine A2b Receptor Promotes Penile Rehabilitation of Refractory Erectile Dysfunction
Advanced ScienceThe mechanisms of adenosine and specific adenosine receptor subtypes in promoting penile rehabilitation remain unclear. Single‐cell RNA sequencing of human corpus cavernosum, adenosine deaminase (ADA) and adenosine receptors knock‐out mice (ADA−/−, A1−/−
Yang Xiong +7 more
doaj +1 more source
Adenosine A2a receptor antagonists attenuate striatal adaptations following dopamine depletion
Neurobiology of Disease, 2012 The motor symptoms of Parkinson's disease (PD) are widely thought to arise from an imbalance in the activity of the two major striatal efferent pathways following the loss of dopamine (DA) signaling.
Jayms D. Peterson +2 more
doaj +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Detrusor smooth muscle surrounding the urinary bladder produces transient pressure events essential for sensing bladder fullness during the filling phase. We investigated the role of adenosine, a ubiquitous signalling molecule, in regulating bladder smooth muscle function.
Gerald M. Herrera +8 more
wiley +1 more source
Molecular Evidence of Adenosine Deaminase Linking Adenosine A2A Receptor and CD26 Proteins
Frontiers in Pharmacology, 2018 Adenosine is an endogenous purine nucleoside that acts in all living systems as a homeostatic network regulator through many pathways, which are adenosine receptor (AR)-dependent and -independent. From a metabolic point of view, adenosine deaminase (ADA)
E. Moreno +7 more
semanticscholar +1 more source
Targeting Metabolic Reprogramming in Tumor: From Mechanisms to Precision Immunotherapies
MedComm – Oncology, Volume 4, Issue 4, December 2025.Cancer metabolic reprogramming is a key hallmark of tumorigenesis and antitumor immunity. It boosts tumor progression by enhancing cancer cell fitness in hostile microenvironments and facilitates immune evasion by evading natural and therapy‐driven antitumor immune responses.
Tong Zhang, Ping Gao, Linchong Sun
wiley +1 more source
CD73 Expression by CD4 + T Cells Marks Early Effector Memory T Cells
Immunology, Volume 176, Issue 4, Page 454-467, December 2025.The role of CD73 in the development of naïve CD4+ T cells. Naïve CD4+ T cells, which are negative for CD25, CD44, and positive for CD62L, are depicted based on the expression of CD73. CD73− and CD73+ subpopulations among naïve CD4+ T cells bear distinct characteristics.
Luxia Chen +5 more
wiley +1 more source
A2A Receptor Antagonism and Dyskinesia in Parkinson’s Disease
Parkinson's Disease, 2012 Dyskinesia, a major complication of treatment of Parkinson’s disease (PD), involves two phases: induction, which is responsible for dyskinesia onset, and expression, which underlies its clinical manifestation.
Micaela Morelli +3 more
doaj +1 more source
Advanced Science, Volume 12, Issue 41, November 6, 2025.Brain diseases involve multilayered metabolic disruptions that reshape cellular interactions and microenvironments. This review outlines core metabolic features across disease states and presents emerging nanodelivery strategies as precision tools to reprogram pathological metabolism.
Jingyi Zhou, Chen Jiang
wiley +1 more source