Results 131 to 140 of about 210,480 (291)
Biotechnology and Bioengineering, EarlyView.Lifecycle perspective on cell and gene therapy manufacturing challenges and enabling GMP solutions. ABSTRACT Cell and gene therapies (CGTs) are revolutionizing modern medicine; however, making these advanced medicines scalable and readily available to commercial manufacturers worldwide is a major challenge. The number of approved CGT products continues
Rajath Samaga +2 more
wiley +1 more source
Status and future of recombinant adeno‐associated virus vector manufacturing
Biotechnology Progress, EarlyView.Abstract Sixty years of adeno‐associated virus (AAV) research illustrates a trajectory marked by basic science exploration, iterative innovation, persistent challenges, a number of clinical setbacks, as well as commercial therapeutic triumphs. This continual evolution has led to recombinant AAV (rAAV) becoming a cornerstone of modern gene therapy ...
Frank Agbogbo, David Dismuke
wiley +1 more source
RETRACTED: Top 100 cited articles on anosmia and COVID‐19: A bibliometric analysis
World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView., 2023 Abstract Objectives With the exponential growth of literature on coronavirus disease 2019 (COVID‐19), we undertook a bibliometric analysis of the top 100 most cited COVID‐19‐related articles in anosmia, to identify high‐impact studies relating to anosmia as a symptom of early COVID‐19 infection.
Denise Jia Yun Tan, Tsz Ki Ko
wiley +1 more source
Genes and DiseasesRecombinant adenovirus (rAdV) is a commonly used vector system for gene transfer. Efficient initial packaging and subsequent production of rAdV remains time-consuming and labor-intensive, possibly attributable to rAdV infection-associated oxidative ...
Guozhi Zhao +23 more
doaj +1 more source
Proteome Analysis of Adenovirus Using Mass Spectrometry
, 2013 Analysis of proteins and their posttranslational modifications is important for understanding different biological events. For analysis of viral proteomes, an optimal protocol includes production of a highly purified virus that can be investigated with a
Sara Bergström Lind +5 more
core +1 more source
Demonstration of nanofiltration‐based virus safety for AAV manufacturing using model viruses
Biotechnology Progress, EarlyView.Abstract Virus safety for biopharmaceutical products has been a well‐established concern for several decades. While various virus reduction steps have been identified and implemented for traditional plasma‐derived and monoclonal antibody products, there are various challenges to achieving the same virus safety in emerging gene therapy products.
Brian Buesing +2 more
wiley +1 more source
Opsoclonus in Pediatric Patients: Differential Diagnosis and a Practical Approach to Evaluation
Annals of the Child Neurology Society, EarlyView.ABSTRACT Opsoclonus is an ocular dyskinesia characterized by involuntary, arrhythmic, multidirectional saccades. In pediatrics, opsoclonus is most commonly attributed to the rare neuroinflammatory disorder opsoclonus‐myoclonus‐ataxia syndrome (OMAS), typically considered a paraneoplastic syndrome associated with neural crest tumors. However, opsoclonus
Aubrey C. Reed +5 more
wiley +1 more source
Capturing and concentrating adenovirus using magnetic anionic nanobeads
International Journal of Nanomedicine, 2016 Akikazu Sakudo,1 Koichi Baba,2 Kazuyoshi Ikuta1,31Department of Virology, Research Institute for Microbial Diseases, Osaka University, Yamadaoka, Suita, Osaka, Japan; 2Baba Pediatric Clinic, Kadoma, Osaka, Japan; 3Kanonji Institute, The Research ...
Sakudo A, Baba K, Ikuta K
doaj