Results 171 to 180 of about 281,343 (303)

An intracellular recombinant single‐chain variable antibody fragment as a new class of phosphodiesterase type 5 inhibitors

British Journal of Pharmacology, EarlyView.
Background and Purpose Cyclic guanosine monophosphate (cGMP) is a ubiquitous second messenger involved in human (patho‐)physiology. Phosphodiesterase 5 (PDE5) is a major cGMP hydrolyzing enzyme in many cell types including vascular smooth muscle cells (VSMCs). Several highly selective PDE5 inhibitors are in clinical use. However, there are currently no
Kürsat Kirkgöz, Sophie Sprenger, Olga Schweigert, Sanika Mohagaonkar, Matti Walsdorff, Tanja Zeller, Filip Berisha, Viacheslav O. Nikolaev, Sergei D. Rybalkin   +8 more
wiley   +1 more source

[Corrigendum] Influence of aspirin on the CX3CL1/CX3CR1 signaling pathway in acute pulmonary embolism. [PDF]

Int J Mol Med
Zhang Z, Yang W, Ying R, Shi Y, Jiang H, Cai D, Kuang J, Yang R, Wang L.   +8 more
europepmc   +1 more source

Therapeutic potential of natural products in cancer immunotherapy: Advances and challenges

British Journal of Pharmacology, EarlyView.
This review systematically outlines the mechanisms underlying tumour immunotherapy resistance and elucidates the role of natural products in enhancing therapeutic efficacy as immunomodulatory adjuvants. Abstract Immunotherapy has emerged as a clinically pivotal approach in cancer treatment, but its application remains limited to a small subset of ...
Rao Hu, Kaibin Dai, Zhensheng Lin, Mingfang Ye, Minfeng Chen, Xiaobo Li, Dongmei Zhang   +6 more
wiley   +1 more source

Transient adenovirus-Cre infection causes long-lasting remodeling of the mammary gland immune landscape. [PDF]

Sci Rep
Han S, Zhao D, Chen X, Zhu M, Li T, Wang C, Chen H, Li Z.   +7 more
europepmc   +1 more source

PLGA‐particle‐based vaccine induces SARS‐CoV‐2‐specific antibody and T‐cell responses

British Journal of Pharmacology, EarlyView.
A novel coronavirus disease 2019 (COVID‐19) vaccine encapsulating recombinant severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) spike receptor binding domain (RBD) with the double stranded RNA (dsRNA) analogue Riboxxim induces robust systemic and respiratory T‐ and B‐cell responses in mice.
Dennis Horvath, Katharina Inholz, Dennis Mink, Alicia Madel, Julia Koerner, Reinhold Horlacher, Michael Basler   +6 more
wiley   +1 more source

Oncolytic Therapy: Delivery System and New Therapeutic Strategies for Cancer. [PDF]

MedComm (2020)
Jin S, Zhang Y, Zhou Z, Zhang Y, Yu T, Xu R, Xu L, Zhang J, Zhang L, Yang S, Wang X.   +10 more
europepmc   +1 more source

FXR1‐Directed Alternative Splicing of MK5 Drives Hepatocellular Carcinoma Progression by Activating GSK3β Signaling

Cancer Science, EarlyView.
The RNA‐binding protein FXR1 promotes hepatocellular carcinoma (HCC) progression by driving alternative splicing of MK5 to generate an oncogenic isoform, MK5‐L, which activates the Wnt/β‐catenin pathway. Targeting FXR1 with an antisense oligonucleotide suppresses tumor growth in vivo, revealing a promising therapeutic strategy for HCC.
Yutong Li, Jin Xiang, Bin Cheng, Chenhao Li, Kai Wang, Ni Tang, Luyi Huang   +6 more
wiley   +1 more source

Enteric Viral Pathogens in Infants in the United States: 2017-2020. [PDF]

Pediatrics
Cannon JL, Baker JM, Mattison CP, Browne H, Nguyen K, Burke RM, Mijatovic-Rustempasic S, Casey-Moore MC, Gautam R, Bartlett E, Embury S, Burrell A, Conrey S, Parashar UD, Payne DC, Staat MA, Morrow AL, Vinjé J.   +17 more
europepmc   +1 more source

Oncolytic Vaccinia Virus‐HSP70‐shRNA Amplifies Viral Replication, ROS/Autophagy, and Immunity to Fight Colorectal Cancer

Cancer Science, EarlyView.
OncoVV‑shHSP70, a vaccinia virus silencing HSP70, demonstrated potent antitumor efficacy in colorectal cancer cell lines, as well as in syngeneic, xenograft, and humanized mouse models. In cell lines, oncoVV‑shHSP70 promoted viral oncolysis and cytokine production through a self‑reinforcing cycle of ROS‑autophagy. In both CT26 and SW620‑humanized mouse
Rentao Yuan, Ruikang Liu, Fangying Shao, Zheqi Cai, Yingfei Fang, Kan Chen, Yanrong Zhou, Ting Ye, Gongchu Li   +8 more
wiley   +1 more source

Complement-Mediated Hemolytic Anemia Triggered by Adenovirus Infection in a Pediatric Patient. [PDF]

Cureus
Fuller G, Anderson M.
europepmc   +1 more source