Results 221 to 230 of about 210,480 (291)

Targeting PCSK9 in Vascular Smooth Muscle Cells: An Effective Strategy to Suppress Ferroptosis and Attenuate Abdominal Aortic Aneurysm Progression

Cell Proliferation, EarlyView.
PCSK9 aggravates AAA by promoting ferroptosis in VSMCs. In the pathological AAA environment, PCSK9 upregulation triggers ferritinophagy‐dependent degradation of FTH1, leading to Fe2+ release, triggering lipid peroxidation and ferroptosis, exacerbating AAA.
Mengdie Xia, Man Li, Yanyu Chen, Jialin Chen, Yuting Cui, Xi‐Long Zheng, Jing Yang, Bingzhao Li, Xiaofeng Ma, Miao Liu, Gang Fan, Juan Peng, Xiaoyan Dai, Zhihan Tang   +13 more
wiley   +1 more source

Resurgence of Human Adenovirus Infections in the Korean Military Following the COVID-19 Pandemic. [PDF]

J Korean Med Sci
Park HW, Lee E, Kwon SH, Ko E, Kim D, Park B.   +5 more
europepmc   +1 more source

PLIN5 Protects Against Ang II‐Induced Podocyte Lipotoxicity by Interacting With FKBP8 and Preserving Lipid Droplet–Mitochondria Contact

Cell Proliferation, EarlyView.
PLIN5‐FKBP8 tethers lipid droplets to mitochondria to counteract Ang II‐induced lipotoxicity. ABSTRACT Chronic kidney disease (CKD) remains a major global health challenge. Angiotensin II (Ang II)‐induced lipotoxicity is an important contributor to podocyte injury.
Ping Wang, Wenjie Chen, Jingjing Ke, Hongtu Hu, Zhuan Peng, Yue Qi, Guohua Ding, Jijia Hu   +7 more
wiley   +1 more source

Epidemiological and Genotypic Trends of Enteric Adenovirus, Astrovirus, and Sapovirus in Gwangju, Korea, 2017-2023. [PDF]

J Korean Med Sci
Lim MH, Kim MJ, Lee JE, Hwang DJ, Lee KH, Ha YD, Gang GL, Seong J, Seo JM.   +8 more
europepmc   +1 more source

USP30 inhibits wound healing in diabetic foot ulcers by promoting TRAF6‐induced ferroptosis and angiogenesis inhibition

Journal of Diabetes Investigation, EarlyView.
High glucose upregulates USP30 in HUVECs, which deubiquitinates and stabilizes TRAF6. Stabilized TRAF6 suppresses GPX4 and SLC7A11, increases ROS/MDA/lipid peroxidation, and activates ferroptosis and apoptosis, leading to impaired angiogenesis and delayed wound healing.
Jingjing Yuan, Shuang Sui, Zhenghua Yang, Kaiwen Zhang, Qiang Hu   +4 more
wiley   +1 more source

Application of metagenomic next-generation sequencing in gastrointestinal infections in children after allogeneic hematopoietic stem cell transplantation. [PDF]

Front Cell Infect Microbiol
Xu Z, Wang Y, Zhang X, Guo F, Chen J, Geng H, Li Y, Gao Y.   +7 more
europepmc   +1 more source

A Pilot Placebo‐Controlled Randomized Trial of Repeated High‐Dose Intravenous Magnesium Sulphate and High‐Dose Nebulized Budesonide for Severe Asthma in the Paediatric Emergency Department

Journal of Paediatrics and Child Health, EarlyView.
ABSTRACT Objective Determine if high‐dose intravenous magnesium with/without nebulized budesonide for children with acute severe asthma is safe and reduces time to medical readiness for discharge compared to standard intravenous magnesium. Methods Either 2 doses of intravenous magnesium or 1 dose and placebo, each with/without high‐dose nebulized ...
Khalid Alansari, Fatin Abou Moussa, Hadi Abu Rasheed, Bruce L. Davidson, Khalid Yousif Ibrahim, Mahmoud Alrifaai   +5 more
wiley   +1 more source

A 3-year wastewater-based epidemiology study of noroviruses in Senegal. [PDF]

Appl Environ Microbiol
Diaw N, Boussiengui GL, Ndiaye N, Barry MA, Kébé O, Dia N, Faye O, Faye M.   +7 more
europepmc   +1 more source

The Role of Viruses in the Pathogenesis of Periodontitis

Journal of Periodontal Research, EarlyView.
This narrative review aimed to summarize current evidence on the presence and potential pathogenic role of viruses in periodontitis. Design: Narrative Review; Population: Patients with periodontitis; Exposure: Detection of viruses in oral samples (biopsies, saliva, gingival crevicular fluid, subgingival plaque, blood); Outcome: Viral prevalence, load ...
Kim Natalie Stolte, Jørgen Slots, Henrik Dommisch   +2 more
wiley   +1 more source

Oncolytic viruses in head and neck cancer: therapeutic promise and translational challenges. [PDF]

Front Immunol
Wang H, Shen H, Zhang M, Mou Y, Ren C, Sun Y, Liu W, Sun C, Li D, Li Y, Qu P, Song X.   +11 more
europepmc   +1 more source