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Seminars in Respiratory and Critical Care Medicine, 2011 Adenoviruses (AdV) are DNA viruses that typically cause mild infections involving the upper or lower respiratory tract, gastrointestinal (GI) tract, or conjunctiva. Rare manifestations of AdV infections include hemorrhagic cystitis, hepatitis, hemorrhagic colitis, pancreatitis, nephritis, or encephalitis.
Joseph P Lynch +2 more
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Gene Therapy, 2000 The use of targeted viral vectors to localize gene transfer to specific cell types holds many advantages over conventional, non-targeted vectors currently used in gene therapy. The resulting improvements in gene localization from targeted adenovirus vectors are likely to reduce immunogenicity and toxicity, increase safety, and enable the systemic ...
Thomas J Wickham
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Endocytosis of adenovirus and adenovirus capsid proteins
Advanced Drug Delivery Reviews, 2003Key proteins of the icosahedral-shaped adenovirus (Ad) capsid mediate infection, and interact with cellular proteins to coordinate stepwise events of cell entry that produce successful gene transfer. Infection is mediated predominantly by the penton and fiber capsid proteins. The fiber initiates cell binding while the penton binds integrin coreceptors,
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Kawasaki? Adenovirus? Kawasaki da adenovirus o con adenovirus?
Medico e Bambino Pagine elettroniche, 2023Kawasaki disease (KD) still represents a challenge for differential diagnosis because it shares clinical features with other infectious diseases. Adenovirus infection has many symptoms that can be found among the diagnostic criteria of KD. However, the two entities have some minor differences that are useful to distinguish them.
Accomando, Francesco +2 more
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Human Gene Therapy, 2004
Structural studies continue to play an essential role as the focus of adenovirus research shifts in emphasis from basic biology to adenovirus-based vector technologies. A crucial step in developing novel therapeutics for gene replacement, cancer, and vaccines is often to modify the virion.
John J, Rux, Roger M, Burnett
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Structural studies continue to play an essential role as the focus of adenovirus research shifts in emphasis from basic biology to adenovirus-based vector technologies. A crucial step in developing novel therapeutics for gene replacement, cancer, and vaccines is often to modify the virion.
John J, Rux, Roger M, Burnett
openaire +2 more sources
The Journal of Gene Medicine, 2003
AbstractPathogen entry into cells occurs by direct penetration of the plasma membrane, clathrin‐mediated endocytosis, caveolar endocytosis, pinocytosis or macropinocytosis. For a particular agent, the infectious pathways are typically restricted, reflecting a tight relationship with the host.
Meier, O, Greber, U F
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AbstractPathogen entry into cells occurs by direct penetration of the plasma membrane, clathrin‐mediated endocytosis, caveolar endocytosis, pinocytosis or macropinocytosis. For a particular agent, the infectious pathways are typically restricted, reflecting a tight relationship with the host.
Meier, O, Greber, U F
openaire +6 more sources