Results 91 to 100 of about 90,117 (254)

Advances in Immunological Combination Therapy for Colorectal Cancer

iMetaMed, EarlyView.
Review the progress of combined immunotherapy for colorectal cancer. ABSTRACT Immune checkpoint inhibitors (ICIs) have been utilized extensively and shown to be therapeutically beneficial in the treatment of solid tumors in recent years. Nonetheless, considerable heterogeneity in Colorectal cancer (CRC) requires careful consideration.
Jiayue Wu, Rongbo Wen, Tianshuai Zhang, Fuao Cao, Xiaoming Zhu, Liqiang Hao, Wei Zhang, Guanyu Yu   +7 more
wiley   +1 more source

Immunological pathogenesis and treatment progress of adenovirus pneumonia in children

Italian Journal of Pediatrics
Human adenovirus is an infectious agent that causes respiratory infections in adults and children. It has been found that immunocompromised children are highly susceptible to this pathogen, as it can swiftly evolve into severe pneumonia with multiple ...
Yaowen Liang, Jie Wei, Jianjun Shen, Zihao Liang, Xiuchang Ma, Yuchen Du, Wenxian Qian, Hui Dong, Ping Huang, Apeng Chen, Changhua Yi   +10 more
doaj   +1 more source

Clinical and Radiological Features of an Adenovirus Type 7 Outbreak in Split-Dalmatia County, Croatia, 2022–2023

Pathogens
Human adenoviruses (HAdVs) are known to be highly contagious pathogens. They are commonly associated with mild respiratory infections in young children but can also cause severe life-threatening infections.
Antea Trogrlic, Dina Mrcela, Danijela Budimir Mrsic, Ivana Jukic, Sanda Sardelic, Irena Tabain, Željka Hruskar, Diana Nonkovic, Josko Markic, Mirela Pavicic Ivelja   +9 more
doaj   +1 more source

Persistent Infection of Human Cells (HeLa) with Adenovirus Type 12.

Experimental Biology and Medicine, 1964
SummaryThe establishment of an adeno-virus type 12 cell carrier system is described. Characteristics of the carrier cultures include an initial dependence on inhibitor or antibody in human serum, an enhanced rate of growth after the fifth day as compared to uninfected cells, a relatively high percentage of infected cells, but a low percentage of ...
G J, VANHOOSIER, C, GIST, G, TAYLOR, J J, TRENTIN   +3 more
openaire   +2 more sources

Hyperoside alleviates endometrial stromal cell senescence in unexplained recurrent spontaneous abortion via DHX9‐mediated R‐loop resolution

iMeta, EarlyView.
This study suggests that the food‐derived flavonoid hyperoside may act as a natural DExH‐box helicase 9 (DHX9) modulator, directly targeting Thr419 of DHX9 to help resolve pathological R‐loop accumulation. Consequently, it suppresses cyclic GMP‐AMP synthase‐stimulator of interferon genes (cGAS‐STING)‐driven endometrial stromal senescence and restores ...
Yuepeng Jiang, Hongli Zhao, Xinyi Ding, Haoling Zhang, Yadong Guo, Yiming Ma, Lingyi Cai, Qingnan Fan, Ruisi Peng, Fuyuan Yang, Doblin Sandai, Xianling Cao, Jiali Yao, Wenyi Wang, Zhiheng Lin, Wangzheqi Zhang, Jialin He, Aihua Zhang, Xiaoxuan Zhao   +18 more
wiley   +1 more source

Prevalence of Influenza Viruses A and B, Adenovirus, Respiratory Syncytial Virus, and Human Metapneumonia Viruses among Children with Acute Respiratory Tract Infection

Advances in Virology
Background. Acute respiratory tract infection (ARTI) is a significant cause of morbidity and mortality among children worldwide. The majority of acute respiratory infections in children are caused by viruses, with respiratory syncytial virus (RSV) being ...
Rana Farzi, Neda Pirbonyeh, Mohammad Rahim Kadivar, Afagh Moattari   +3 more
doaj   +1 more source

GSK3β drives early diabetic tubulopathy via TFEB‐mediated mitochondrial dysfunction

Interdisciplinary Medicine, EarlyView.
Mitochondrial dysfunction, including mitochondrial biogenesis, mitophagy, dynamics and oxidative stress, occurs in the early stages of diabetic tubulopathy, which precede proteinuria and renal histological changes. GSK3β is a potential novel biomarker for the prediction of diabetic tubulopathy.
Lan Yao, Xianhui Liang, Bingyu Li, Bohan Chen, Xiaoyang Wang, Mei Hong, Qi Feng, Yingjin Qiao, Zhangsuo Liu, Kai Wang, Pei Wang   +10 more
wiley   +1 more source

Impact of co-infections and immune responses on clinical severity of human adenovirus 3 and 7 infections in hospitalized children with lower respiratory tract infections: a comparative study

Frontiers in Cellular and Infection Microbiology
BackgroundThe pathogenic distribution of co-infections and immunological status of patients infected with human adenovirus serotypes 3 or 7 (HAdV-3 or HAdV-7) were poorly understood.MethodsThis study involved a retrospective analysis of respiratory ...
Xiaolin Ma, Yuting Wu, Ri De, Hailan Yao, Feng He, Yi Wang, Wei Wang, Chao Yan, Qinwei Song, Chunjie Guo, Li Wen, Linqing Zhao, Ling Cao, Chunmei Zhu   +13 more
doaj   +1 more source

Analysis of genetic heterogeneity in the HCAR adenovirus-binding Ig1 domain in a Caucasian Flemish population

BMC Genetics, 2002
Background Polymorphisms in the gene that encodes the human cellular receptor for group B coxsackieviruses and adenoviruses (HCAR) could be responsible for differences in susceptibility to infections with these pathogens.
Inge Thoelen, Griet Duson, Elke Wollants, Marc Van Ranst   +3 more
doaj   +1 more source

Bacterial RecA Protein Promotes Adenoviral Recombination during In Vitro Infection

mSphere, 2018
Adenovirus infections in humans are common and sometimes lethal. Adenovirus-derived vectors are also commonly chosen for gene therapy in human clinical trials.
Jeong Yoon Lee, Ji Sun Lee, Emma C. Materne, Rahul Rajala, Ashrafali M. Ismail, Donald Seto, David W. Dyer, Jaya Rajaiya, James Chodosh   +8 more
doaj   +1 more source