Results 81 to 90 of about 90,117 (254)

Status and future of recombinant adeno‐associated virus vector manufacturing

Biotechnology Progress, EarlyView.
Abstract Sixty years of adeno‐associated virus (AAV) research illustrates a trajectory marked by basic science exploration, iterative innovation, persistent challenges, a number of clinical setbacks, as well as commercial therapeutic triumphs. This continual evolution has led to recombinant AAV (rAAV) becoming a cornerstone of modern gene therapy ...
Frank Agbogbo, David Dismuke
wiley   +1 more source

Deaths Associated with Human Adenovirus-14p1 Infections, Europe, 2009–2010

Emerging Infectious Diseases, 2011
Human adenovirus (HAdV) serotype 14 is rarely identified. However, an emerging variant, termed HAdV-14p1, recently has been described in the United States in association with outbreaks of acute respiratory disease with high rates of illness and death. We
Michael J. Carr, Adriana E. Kajon, Xiaoyan Lu, Linda Dunford, Paul O’Reilly, Paul Holder, Cillian F. De Gascun, Suzie Coughlan, Jeff Connell, Dean D. Erdman, William W. Hall   +10 more
doaj   +1 more source

Data on the expression of cellular lncRNAs in human adenovirus infected cells

Data in Brief, 2016
Expression of cellular long non-coding RNAs (lncRNAs) in human primary lung fibroblasts (IMR-90) during the course of adenovirus type 2 (Ad2) infection was studied by strand-specific whole transcriptome sequencing. In total, 645 cellular lncRNAs were expressed at a significant level and 398 of them were changed more than 2-fold.
Chen M, Zhao H, Lind SB, Pettersson U
openaire   +5 more sources

Fecal Microbiota Transplantation and Microbiota‐Based Therapeutics in Allogeneic Hematopoietic Stem Cell Transplantation: Current Evidence and Future Directions

Clinical Pharmacology &Therapeutics, EarlyView.
The intestinal microbiome is a key regulator of immune homeostasis, metabolism, and epithelial barrier integrity. In patients with malignant hematological diseases, particularly those undergoing hematopoietic stem cell transplantation, microbiome perturbations by reduced diversity, pathobiont expansion, and loss of beneficial metabolites are common as ...
Bálint Gergely Szabó, Dorina Korózs, Michal Bator, Krisztina Jeszenszky, Viktor Lakatos, László Gopcsa, Péter Reményi, János Sinkó   +7 more
wiley   +1 more source

CryoEM structure of adenovirus type 3 fibre with desmoglein 2 shows an unusual mode of receptor engagement

Nature Communications, 2019
Human adenoviruses (HAd) cause respiratory, gastrointestinal and ocular infections. Here, the authors provide insights into the early stages of adenovirus infection by determining the cryo-EM structure of the trimeric HAd type 3 fibre knob bound to its ...
Emilie Vassal-Stermann, Gregory Effantin, Chloe Zubieta, Wim Burmeister, Frédéric Iseni, Hongjie Wang, André Lieber, Guy Schoehn, Pascal Fender   +8 more
doaj   +1 more source

Can epilepsy be predicted after the first febrile seizure? Insights from machine learning of postictal EEG

Epileptic Disorders, EarlyView.
Abstract Objective Febrile seizures (FS) are the most common seizures in childhood, yet identifying children at risk of developing epilepsy after the first FS remains challenging. We aimed to evaluate the prognostic potential of machine learning (ML) algorithms applied to post‐febrile seizure electroencephalography (EEG) recordings.
Boran Şekeroğlu, Hüseyin Öztoprak, Özlem Yayıcı Köken, Hatice Demir, Mehpare Sarı Yanartaş, Deniz Yılmaz, Burçin Şanlıdağ, Ayşegül Neşe Çıtak Kurt   +7 more
wiley   +1 more source

Development of a prototype immunochromatographic test for rapid diagnosis of respiratory adenovirus infection

Brazilian Journal of Infectious Diseases, 2017
Human adenoviruses comprise an important group of etiologic agents that are responsible for various diseases in adults and children, such as respiratory, ocular, gastroenteric, and urinary infections.
Inarei Paulini, Joselma Siqueira-Silva, Luciana Thomaz, Leticia Rocha, Charlotte Harsi, Nancy Bellei, Celso Granato   +6 more
doaj   +1 more source

Attempts to Infect Rhesus Monkeys with Human Type 4 Adenovirus

Experimental Biology and Medicine, 1968
SummaryIn searching for an animal model for human adenovirus studies we have attempted to infect rhesus monkeys with a human type 4 adenovirus. The results were inconclusive but we have some evidence to suggest that infection and replication might have occurred in several animals. Communicability among cagemates was not demonstrated.
F A, Pedreira, N M, Tauraso, A E, Palmer, A, Shelokov, R L, Kirschstein   +4 more
openaire   +2 more sources

Molecular Survey of Viral and Bacterial Causes of Childhood Diarrhea in Khartoum State, Sudan

Frontiers in Microbiology, 2018
Diarrheal disease is a major public health problem for children in developing countries. Knowledge of etiology that causes diarrheal illness is essential to implement public health measures to prevent and control this disease. Published studies regarding
Mosab A. Adam, Mosab A. Adam, Ji Wang, Khalid-A. Enan, Hongwei Shen, Hongwei Shen, Hao Wang, Abdel R. El Hussein, Azza B. Musa, Isam M. Khidir, Isam M. Khidir, Xuejun Ma   +11 more
doaj   +1 more source

Molecular epidemiology of human adenovirus infections in Denmark, 2011–2016

Journal of Clinical Virology, 2018
Human adenoviruses (HAdVs) can cause respiratory tract infections, conjunctivitis, diarrhoea and outbreaks have been reported. However, little is known about the disease burden and the molecular epidemiology of HAdV.To retrospectively perform a molecular characterization of HAdV positive samples received at Statens Serum Institut during the period 2011-
Barnadas, Céline, Schmidt, Dennis Jelsbak, Fischer, Thea K., Fonager, Jannik   +3 more
openaire   +3 more sources