Results 81 to 90 of about 2,709 (155)

The potential of a novel Adenovirus vector for vaccination [PDF]

Adenoviruses (Ads) have many attractive characteristics for use as agents of genebased vaccines and therapies. The most frequently used Ad vectors in preclinical research are based on Ad5.
Martin, Stuart
core  

Modification of the E1-pIX region of the adenovirus 5 genome for use in cancer gene therapy

, 2008
Currently the use of adenoviruses in cancer gene therapy is limited by efficient delivery of the virus into the tumour cells, detargeting of the virus from the liver, and the efficient spread of the virus within the tumour.
Kallioinen, Susanna E.
core  

Rodents Versus Pig Model for Assessing the Performance of Serotype Chimeric Ad5/3 Oncolytic Adenoviruses

, 2019
Oncolytic adenoviruses (Ad) are promising tools for cancer therapeutics. Most Ad-based therapies utilize species C serotypes, with Adenovirus type 5 (Ad5) most commonly employed. Prior clinical trials demonstrated low efficiency of oncolytic Ad5 vectors,
Julia Davydova, George Ruth, Michele Dunning, Richard W. Bianco, Lisa Koodie, Malavika Chandrashekar, Matthew G. Robertson   +6 more
core   +1 more source

Should the criteria for species distinction in adenoviruses be reconsidered? Evidence from canine adenoviruses 1 and 2.

Intervirology, 1985
Four strains of canine adenovirus type 1 (CAV-1) and two strains of canine adenovirus type 2 (CAV-2) were examined by restriction enzyme analysis. In all cases, CAV-1 could be readily differentiated from CAV-2. Additionally, monoclonal antibodies were prepared against the Mirandola and Manhattan strains of CAV-1 and CAV-2, respectively.
openaire   +1 more source

Diagnosis of Infectious Canine Hepatitis Virus (CAV-1) Infection in Puppies with Encephalopathy

, 2005
Nine weaned Labrador Retriever puppies from a litter of 11 were presented with signs of acute central nervous system (CNS) disease that included ataxia and blindness. All puppies died.
A. W. Confer, A. Berry, D. Caudell, R. W. Fulton, G. M. Fent, J. W. Ritchey, J. T. Saliki   +6 more
core   +1 more source

Detection of canine adenovirus 1 in red foxes (Vulpes vulpes) and raccoons (Procyon lotor) in Germany with a TaqMan real-time PCR assay

, 2017
We developed a real-time (rt)PCR assay based on TaqMan probe technology for the specific detection of canine adenovirus 1 (CAdV-1). The assay is able to detect three 50% tissue culture infectious dose/mL in CAdV-1–containing cell culture supernatant ...
Michael Zschöck, Silke Hechinger, Hans-Peter Hamann, Svenja Scheffold   +3 more
core   +1 more source

A duplex real-time PCR assay based on TaqMan technology for simultaneous detection and differentiation of canine adenovirus types 1 and 2

, 2016
Canine adenoviruses are a major cause of disease in dogs, coyotes, red foxes and wolves, as well as in other carnivores and marine mammals. Canine adenovirus type 1 (CAdV-1) and canine adenovirus type 2 (CAdV-2) cause infectious canine hepatitis (ICH ...
BUONAVOGLIA, Canio, DOWGIER, GIULIA, MARTELLA, Vito, DECARO, Nicola, Colaianni, Maria Loredana, CIRONE, Francesco, LOSURDO, MICHELE, MARI, VIVIANA, LAROCCA, VITTORIO, LUCENTE, MARIA STELLA   +9 more
core   +1 more source

Sustained high-level expression of human factor IX (hFIX) after liver-targeted delivery of recombinant adeno-associated virus encoding the hFIX gene in rhesus macaques

, 2002
The feasibility, safety, and efficacy of liver-directed gene transfer was evaluated in 5 male macaques (aged 2.5 to 6.5 years) by using a recombinant adeno-associated viral (rAAV) vector (rAAV-2 CAGG-hFIX) that had previously mediated persistent ...
Hanawa, H, Ng, CYC, Mandrell, TD, Vanin, EF, Nathwani, AC, Hu, Y, Davidoff, AM, Hoffer, FA, Zhou, J, Slaughter, C, Nikanorov, A, Lozier, JN, Nienhuis, AW   +12 more
core  

Practical guidelines for producing non-replicating canine adenovirus vectors. [PDF]

PLoS One
Omara D, Ndekezi C, Mugaba S, Nakyanzi A, Bukenya H, Bwogi J, Natwijuka F, Kapaata A, Kato F, Byamukama D, Ayebale ML, Kateete DP, Serwanga J, Cose S, Obondo SJ, Kaleebu P, Balinda SN.   +16 more
europepmc   +1 more source

Intrinsic immune properties of carrier MSC impact on the clinical outcome of children with solid tumors receiving oncolytic virotherapy. [PDF]

Exp Hematol Oncol
Morales-Molina A, Franco-Luzón L, Garcia-Rodriguez P, González-Murillo A, García-Castro J, Ramírez M.   +5 more
europepmc   +1 more source