Results 1 to 10 of about 729,991 (222)

Antibody-Dependent Enhancement: ″Evil″ Antibodies Favorable for Viral Infections

Viruses, 2022
The pandemics caused by emerging viruses such as severe acute respiratory syndrome coronavirus 2 result in severe disruptions to public health. Vaccines and antibody drugs play essential roles in the control and prevention of emerging infectious diseases.
Xiaoke Yang, Xin Zhang, Xiaotian Zhao, Mengqi Yuan, Kehui Zhang, Jingwen Dai, Xiangyu Guan, Hua-Ji Qiu, Yongfeng Li   +8 more
openaire   +4 more sources

Prevalence of chikungunya virus infection in Sabah, Malaysia during 2017–2020

Tropical Medicine and Health
Background Chikungunya virus (CHIKV) is a mosquito-borne alphavirus and an emerging global health threat. Most research on CHIKV in Malaysia has primarily focused on Peninsular Malaysia, with limited data on its distribution in the endemic regions of ...
Mya Myat Ngwe Tun, Jecelyn Leaslie John, Thanh Vu Nguyen, Maurine Mumo Mutua, Abdul Marsudi Manah, Yuki Takamatsu, Takeshi Urano, Kouichi Morita, Kamruddin Ahmed   +8 more
doaj   +1 more source

Humoral and Mucosal Antibody Response to RSV Structural Proteins in RSV-Infected Adult Hematopoietic Cell Transplant (HCT) Recipients

Viruses, 2021
Respiratory syncytial virus (RSV) is an important cause of lower respiratory tract infection in infants, the elderly, and immunocompromised patients. RSV antibodies play a role in preventing reinfection and in clearance of RSV, but data regarding the ...
Xunyan Ye, Obinna P. Iwuchukwu, Vasanthi Avadhanula, Letisha O. Aideyan, Trevor J. McBride, David M. Henke, Kirtida D. Patel, Felipe-Andres Piedra, Laura S. Angelo, Dimpy P. Shah, Roy F. Chemaly, Pedro A. Piedra   +11 more
doaj   +1 more source

Antibody response to a viral transcriptional regulator

FEBS Letters, 2002
The E2 transcriptional activator of the human papillomavirus regulates the expression of most viral transcripts. Its binding to specific target DNA sequences involves large conformational changes in the interacting macromolecules. The high stability of the E2:DNA complex prompted us to analyze the role of macromolecular interactions and adjuvant ...
Cerutti, Maria Laura, Centeno, Juan M., de Prat Gay, Gonzalo, Goldbaum, Fernando Alberto   +3 more
openaire   +3 more sources

Influenza Virus-cell Fusion Inhibition Assay

Bio-Protocol, 2013
During viral infection to host cells, several viruses undergo the process of endocytosis and pH-dependent fusion. By fusion of viral membrane with host cellular membrane, the viral core invades to host cytoplasm.
Mayo Yasugi, Kazuyoshi Ikuta
doaj   +1 more source

A Novel, Comprehensive A129 Mouse Model for Investigating Dengue Vaccines and Evaluating Pathogenesis

Vaccines, 2023
In search of a mouse model for use in evaluating dengue vaccines, we assessed A129 mice that lacked IFN-α/β receptors, rendering them susceptible to dengue virus (DENV) infection.
Mya Myat Ngwe Tun, Khine Mya Nwe, Jean Claude Balingit, Yuki Takamatsu, Shingo Inoue, Basu Dev Pandey, Takeshi Urano, Michinori Kohara, Kyoko Tsukiyama-Kohara, Kouichi Morita   +9 more
doaj   +1 more source

Antibody Neutralization of HIV-1 Crossing the Blood-Brain Barrier

mBio, 2020
HIV-1 can cross the blood-brain barrier (BBB) to penetrate the brain and infect target cells, causing neurocognitive disorders as a result of neuroinflammation and brain damage.
Valérie Lorin, Anne Danckaert, Françoise Porrot, Olivier Schwartz, Philippe V. Afonso, Hugo Mouquet   +5 more
doaj   +1 more source

Potent SARS-CoV-2 neutralizing antibodies with therapeutic effects in two animal models

iScience, 2022
Summary: The use of therapeutic neutralizing antibodies against SARS-CoV-2 infection has been highly effective. However, there remain few practical antibodies against viruses that are acquiring mutations.
Masaru Takeshita, Hidehiro Fukuyama, Katsuhiko Kamada, Takehisa Matsumoto, Chieko Makino-Okamura, Tomomi Uchikubo-Kamo, Yuri Tomabechi, Kazuharu Hanada, Saya Moriyama, Yoshimasa Takahashi, Hirohito Ishigaki, Misako Nakayama, Cong Thanh Nguyen, Yoshinori Kitagawa, Yasushi Itoh, Masaki Imai, Tadashi Maemura, Yuri Furusawa, Hiroshi Ueki, Kiyoko Iwatsuki-Horimoto, Mutsumi Ito, Seiya Yamayoshi, Yoshihiro Kawaoka, Mikako Shirouzu, Makoto Ishii, Hideyuki Saya, Yasushi Kondo, Yuko Kaneko, Katsuya Suzuki, Koichi Fukunaga, Tsutomu Takeuchi   +30 more
doaj   +1 more source

A high-throughput screening assay to identify inhibitory antibodies targeting alphavirus release

Virology Journal, 2022
Background Several studies have demonstrated neutralizing antibodies to be highly effective against alphavirus infection in animal models, both prophylactically and remedially.
Anushka Ramjag, Sergej Cutrone, Kai Lu, Christine Crasto, Jing Jin, Sonia Bakkour, Christine V. F. Carrington, Graham Simmons   +7 more
doaj   +1 more source

Post-Immune Antibodies in HIV-1 Infection in the Context of Vaccine Development: A Variety of Biological Functions and Catalytic Activities

Vaccines, 2022
Unlike many other viruses, HIV-1 is highly variable. The structure of the viral envelope changes as the infection progresses and is one of the biggest obstacles in developing an HIV-1 vaccine.
Anna Timofeeva, Sergey Sedykh, Georgy Nevinsky   +2 more
doaj   +1 more source