Results 21 to 30 of about 1,796,854 (312)

Impaired antibody response causes persistence of prototypic T cell-contained virus [PDF]

, 2009
CD8 T cells are recognized key players in control of persistent virus infections, but increasing evidence suggests that assistance from other immune mediators is also needed. Here, we investigated whether specific antibody responses contribute to control
André Fitsche, Bruno Eschli, Lukas Flatz, Senn, Beatrice M., Marylise Fernandez, Ahmed N Hegazy, Verbeek, J Sjef, Eschli, Bruno, Fink, Katja, Rami Sommerstein, Doron Merkler, Daniel D Pinschewer, Katja Fink, Siegrist, Claire-Anne, Odermatt, Bernhard, Andreas Bergthaler, Horvath, Edit, Fitsche, André, Bergthaler, Andreas, Claire-Anne Siegrist, Holdener, Martin, Beatrice M Senn, Verbeek, J. Sjef, Admar Verschoor, J Sjef Verbeek, Verschoor, Admar, Merkler, Doron, Edit Horvath, Pinschewer, Daniel, Martin Holdener, Bernhard Odermatt, Flatz, Lukas, Pinschewer, Daniel D., Sommerstein, Rami, Hegazy, Ahmed N., Fernandez, Marylise, Merkler D, Verbeek JS, Siegrist CA, Fitsche A, Flatz L, Verschoor A, Holdener M, Bergthaler, A;Flatz, L;Verschoor, A;Hegazy, AN;Holdener, M;Fink, K;Eschli, B;Merkler, D;Sommerstein, R;Horvath, E;Fernandez, M;Fitsche, A;Senn, BM;Verbeek, JS;Odermatt, B;Siegrist, CA;Pinschewer, DD, Senn BM, Pinschewer DD, Odermatt B, Sommerstein R, Fernandez M, Fink K, Eschli B, Bergthaler A, Hegazy AN, Horvath E   +53 more
core   +1 more source

Broadly neutralizing anti-HIV-1 antibodies tether viral particles at the surface of infected cells [PDF]

, 2022
International audienceBroadly neutralizing antibodies (bNAbs) targeting the HIV-1 envelope glycoprotein (Env) are promising molecules for therapeutic or prophylactic interventions.
Dufloo, Jérémy, Guivel-Benhassine, Florence, Planchais, Cyril, Frémont, Stéphane, Mouquet, Hugo, Lorin, Valerie, Echard, Arnaud, Stefic, Karl, Schwartz, Olivier, Roingeard, Philippe, Bruel, Timothée, Casartelli, Nicoletta, Karl Stefic, Arnaud Echard, Cyril Planchais, Florence Guivel-Benhassine, Timothée Bruel, Stéphane Frémont, Olivier Schwartz, Hugo Mouquet, Valérie Lorin, Jérémy Dufloo, Nicoletta Casartelli, Philippe Roingeard   +23 more
core   +1 more source

Hepatitis C virus (HCV) infection may elicit neutralizing antibodies targeting epitopes conserved in all viral genotypes [PDF]

, 2009
Anti-hepatitis C virus (HCV) cross-neutralizing human monoclonal antibodies, directed against conserved epitopes on surface E2 glycoprotein, are central tools for understanding virus-host interplay, and for planning strategies for prevention and ...
Patel, Ah, Ball Jonathan K., Nicasio Mancini, Nicola Clementi, Sautto, G, Clementi, N., Ball, J.K., Diotti, R.A., Burioni, R., Mario Perotti, Arvind H Patel, Nitti Giovanni, Diotti, Ra, Clementi Massimo, CLEMENTI, NICOLA, BURIONI, ROBERTO, Sautto, G., CLEMENTI, MASSIMO, Perotti, M., Jonathan K Ball, Massimo Clementi, Nitti, G, Giovanni Nitti, Patel, A.H., Clementi, M., Perotti Mario, Ball, Jk, Perotti, M, Patel Arvind H., Roberta A Diotti, Giuseppe Sautto, Mancini Nicasio, Diotti Roberta A., Mancini, N., Roberto Burioni, Sautto Giuseppe, MANCINI, NICASIO, Clementi Nicola, Burioni Roberto, Nitti, G.   +39 more
core   +1 more source

VIRAL ANTIBODIES IN PRESCHOOL CHILDREN [PDF]

Iranian Journal of Public Health, 1974
One hundred sera from children 1 - 6 years of age, representative of a large serum collection, were tested for the prevalence of antibodies against different viruses.
S. Saidi
doaj   +1 more source

Protective mechanisms of nonneutralizing antiviral antibodies.

PLoS Pathogens, 2023
Antibodies that can bind to viruses but are unable to block infection in cell culture are known as "nonneutralizing antibodies." Such antibodies are nearly universally elicited following viral infection and have been characterized in viral infections ...
Tawny L Chandler, Agnes Yang, Claire E Otero, Sallie R Permar, Sarah L Caddy   +4 more
doaj   +1 more source

Antibody barriers to going viral [PDF]

Journal of Experimental Medicine, 2019
Antibody neutralization of a virus in vitro is often associated with protection against viral exposure in vivo, but the mechanisms operational in vivo are often unclear. By investigating a large number of antibodies, Earnest et al. (https://doi.org/10.1084/jem.20190736) show the importance of antibody effector function in neutralizing antibody ...
openaire   +2 more sources

Antibody response against selected epitopes in the HIV-1 envelope gp41 ectodomain contributes to reduce viral burden in HIV-1 infected patients

Scientific Reports, 2021
The ectodomain of gp41 is the target of potent binding and neutralizing antibodies (NAbs) and is being explored in new strategies for antibody-based HIV vaccines. Previous studies have suggested that the W164A-3S (3S) and EC26-2A4 (EC26) peptides located
Rute Marcelino, Filipa Gramacho, Francisco Martin, Pedro Brogueira, Nuno Janeiro, Claudia Afonso, Robert Badura, Emília Valadas, Kamal Mansinho, Luís Caldeira, Nuno Taveira, José M. Marcelino   +11 more
doaj   +1 more source

SIGNIFICANCE OF BIVALENCE OF ANTIBODY IN VIRAL NEUTRALIZATION [PDF]

The Journal of Experimental Medicine, 1971
The role of bivalence of antibody in its capacity to neutralize virus was studied with rabbit antibodies to the bacteriophage, ϕX174. Univalent Fab or Fab' fragments of IgG isolated from antiviral antisera obtained early in the immunization schedule had virtually no activity compared to that of the intact IgG.
R W, Rosenstein, A, Nisonoff, J W, Uhr
openaire   +2 more sources

Enzyme-linked immunosorbent assay using a virus type-specific peptide based on a subdomain of envelope protein e(rns) for serologic diagnosis of pestivirus infections in swine [PDF]

, 2001
Peptides deduced from the C-terminal end (residues 191 to 227) of pestivirus envelope protein Erns were used to develop enzyme-linked immunosorbent assays (ELISAs) to measure specifically antibodies against different types of pestiviruses.
Langedijk, J.P., Smit, J.A., de, Meloen, R.H., Middel, W.G., Kramps, J.A.   +4 more
core   +1 more source

The Vestigial Esterase Domain of Haemagglutinin of H5N1 Avian Influenza A Virus: Antigenicity and Contribution to Viral Pathogenesis

Vaccines, 2018
Initial attempts to develop monoclonal antibodies as therapeutics to resolve influenza infections focused mainly on searching for antibodies with the potential to neutralise the virus in vitro with classical haemagglutination inhibition and ...
Zhiqiang Zheng, Subha Sankar Paul, Xiaobing Mo, Yu-Ren Adam Yuan, Yee-Joo Tan   +4 more
doaj   +1 more source