Results 21 to 30 of about 732,545 (316)

Protective mechanisms of nonneutralizing antiviral antibodies.

PLoS Pathogens, 2023
Antibodies that can bind to viruses but are unable to block infection in cell culture are known as "nonneutralizing antibodies." Such antibodies are nearly universally elicited following viral infection and have been characterized in viral infections ...
Tawny L Chandler, Agnes Yang, Claire E Otero, Sallie R Permar, Sarah L Caddy   +4 more
doaj   +1 more source

Impaired antibody response causes persistence of prototypic T cell-contained virus [PDF]

, 2009
CD8 T cells are recognized key players in control of persistent virus infections, but increasing evidence suggests that assistance from other immune mediators is also needed. Here, we investigated whether specific antibody responses contribute to control
André Fitsche, Bruno Eschli, Lukas Flatz, Senn, Beatrice M., Marylise Fernandez, Ahmed N Hegazy, Verbeek, J Sjef, Eschli, Bruno, Fink, Katja, Rami Sommerstein, Doron Merkler, Daniel D Pinschewer, Katja Fink, Siegrist, Claire-Anne, Odermatt, Bernhard, Andreas Bergthaler, Horvath, Edit, Fitsche, André, Bergthaler, Andreas, Claire-Anne Siegrist, Holdener, Martin, Beatrice M Senn, Verbeek, J. Sjef, Admar Verschoor, J Sjef Verbeek, Verschoor, Admar, Merkler, Doron, Edit Horvath, Pinschewer, Daniel, Martin Holdener, Bernhard Odermatt, Flatz, Lukas, Pinschewer, Daniel D., Sommerstein, Rami, Hegazy, Ahmed N., Fernandez, Marylise   +35 more
core   +1 more source

Behaviour of non-donor specific antibodies during rapid re-synthesis of donor specific HLA antibodies after antibody incompatible renal transplantation [PDF]

, 2013
Background: HLA directed antibodies play an important role in acute and chronic allograft rejection. During viral infection of a patient with HLA antibodies, the HLA antibody levels may rise even though there is no new immunization with antigen ...
Rizwan Hamer, Imray, C. (Chris), Nithya S Krishnan, Lam Chin Tan, Higgins Robert M., Daga Sunil, Lowe, David Philip, David Briggs, Zehnder Daniel, Tan Lam Chin, Zehnder, Daniel, Robert M Higgins, Daniel Zehnder, Kashi Habib, Dave Lowe, Christopher Imray, Sunil Daga, Neil Raymond, Krishnan, Nithya S., Lam, F. T., Higgins, Rob, Lam F. T., Habib Kashi, Daga, Sunil, F T Lam, Krishnan Nithya S., Lowe Dave, Hamer, Rizwan, Briggs David, Kashi, Habib, Briggs, David, Dr., Raymond Neil, Raymond, Neil T., Hamer Rizwan, Tan, Lam Chin, Imray Christopher   +35 more
core   +1 more source

Viral interference with antibody and complement

Seminars in Cell & Developmental Biology, 1998
Viruses have evolved strategies to evade immunity mediated by antibody and complement. Herpesviruses and coronaviruses encode IgG Fc binding proteins that inhibit IgG activity, enabling the virus or infected cell to escape antibody attack. Herpesviruses, vaccinia virus and HIV-1 have the capacity to interfere with complement, either by incorporation of
Lubinski, John, Nagashunmugam, Thandavarayan, Friedman, Harvey M.   +2 more
openaire   +2 more sources

Antibodies Are Not Essential for the Resolution of Primary Cytomegalovirus Infection but Limit Dissemination of Recurrent Virus [PDF]

, 1994
Virus shedding from the epithelial cells of the serous acini of salivary glands is a major source for the horizontal transmission of cytomegalovirus. These cells are, different to other tissues, exempt from CD8 T lymphocyte control. CD4 T lymphocytes are
Crnkovic, Irena, Koszinowski, Ulrich H., Koszinovski, UH, I Crnković, U H Koszinowski, Pavic, Ivica, S Jonjić, Lucin, Pero, I Pavić, B Polić, P Lucin, Polic, Bojan, Jonjic, Stipan   +12 more
core   +1 more source

Antibody response against selected epitopes in the HIV-1 envelope gp41 ectodomain contributes to reduce viral burden in HIV-1 infected patients

Scientific Reports, 2021
The ectodomain of gp41 is the target of potent binding and neutralizing antibodies (NAbs) and is being explored in new strategies for antibody-based HIV vaccines. Previous studies have suggested that the W164A-3S (3S) and EC26-2A4 (EC26) peptides located
Rute Marcelino, Filipa Gramacho, Francisco Martin, Pedro Brogueira, Nuno Janeiro, Claudia Afonso, Robert Badura, Emília Valadas, Kamal Mansinho, Luís Caldeira, Nuno Taveira, José M. Marcelino   +11 more
doaj   +1 more source

SIGNIFICANCE OF BIVALENCE OF ANTIBODY IN VIRAL NEUTRALIZATION [PDF]

The Journal of Experimental Medicine, 1971
The role of bivalence of antibody in its capacity to neutralize virus was studied with rabbit antibodies to the bacteriophage, ϕX174. Univalent Fab or Fab' fragments of IgG isolated from antiviral antisera obtained early in the immunization schedule had virtually no activity compared to that of the intact IgG.
R W, Rosenstein, A, Nisonoff, J W, Uhr
openaire   +2 more sources

The Vestigial Esterase Domain of Haemagglutinin of H5N1 Avian Influenza A Virus: Antigenicity and Contribution to Viral Pathogenesis

Vaccines, 2018
Initial attempts to develop monoclonal antibodies as therapeutics to resolve influenza infections focused mainly on searching for antibodies with the potential to neutralise the virus in vitro with classical haemagglutination inhibition and ...
Zhiqiang Zheng, Subha Sankar Paul, Xiaobing Mo, Yu-Ren Adam Yuan, Yee-Joo Tan   +4 more
doaj   +1 more source

Antibody barriers to going viral [PDF]

Journal of Experimental Medicine, 2019
Antibody neutralization of a virus in vitro is often associated with protection against viral exposure in vivo, but the mechanisms operational in vivo are often unclear. By investigating a large number of antibodies, Earnest et al. (https://doi.org/10.1084/jem.20190736) show the importance of antibody effector function in neutralizing antibody ...
openaire   +2 more sources

Cure of chronic viral infection and virus-induced type 1 diabetes by neutralizing antibodies [PDF]

, 2009
The use of neutralizing antibodies is one of the most successful methods to interfere with receptor–ligand interactions in vivo. In particular blockade of soluble inflammatory mediators or their corresponding cellular receptors was proven an effective ...
Christen, Urs, Ejrnaes, Mette, Herrath, Matthias G. von   +2 more
core   +1 more source