The inhibition of adenylate kinase by 2,4-thiazolidinedione evaluated by protein-ligand docking [PDF]
ADMET and DMPK, 2017 Due to its crucial role in nucleotide metabolism, adenylate kinase deserves a special attention in screening of potential inhibitors. Herein, we report the assessment of the relative orientation of the ligand 2,4-thiazolidinedione to adenylate kinase ...
Mihaela Ileana Ionescu
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Adenylate kinase 1 overexpression increases locomotor activity in medaka fish [PDF]
PLoS ONE, 2022 Maintenance of the energy balance is indispensable for cell survival and function. Adenylate kinase (Ak) is a ubiquitous enzyme highly conserved among many organisms.
Michiyo Maruyama +5 more
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Adenylate Kinase and Metabolic Signaling in Cancer Cells [PDF]
Frontiers in Oncology, 2020 A hallmark of cancer cells is the ability to rewire their bioenergetics and metabolic signaling circuits to fuel their uncontrolled proliferation and metastasis. Adenylate kinase (AK) is the critical enzyme in the metabolic monitoring of cellular adenine
Aleksandr Klepinin +6 more
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Hypoxanthine-Guanine Phosphoribosyltransferase/adenylate Kinase From Zobellia galactanivorans: A Bifunctional Catalyst for the Synthesis of Nucleoside-5′-Mono-, Di- and Triphosphates [PDF]
Frontiers in Bioengineering and Biotechnology, 2020 In our search for novel biocatalysts for the synthesis of nucleic acid derivatives, we found a good candidate in a putative dual-domain hypoxanthine-guanine phosphoribosyltransferase (HGPRT)/adenylate kinase (AMPK) from Zobellia galactanivorans (ZgHGPRT ...
Javier Acosta +9 more
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β-Cyclodextrins alter the energy metabolism-related enzyme activities in rats [PDF]
Anais da Academia Brasileira de Ciências, 2023 Although widely used in medicine, separation technology, and other fields, the effects of cyclodextrins on the activities of phosphoryl transfer enzymes have not been previously evaluated. In vivo studies evaluated the function of cyclodextrins as active
FRANCINE R. IANISKI +15 more
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Developmental enhancement of adenylate kinase-AMPK metabolic signaling axis supports stem cell cardiac differentiation. [PDF]
PLoS ONE, 2011 Energetic and metabolic circuits that orchestrate cell differentiation are largely unknown. Adenylate kinase (AK) and associated AMP-activated protein kinase (AMPK) constitute a major metabolic signaling axis, yet the role of this system in guiding ...
Petras P Dzeja +4 more
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Correlated inter-domain motions in adenylate kinase. [PDF]
PLoS Computational Biology, 2014 Correlated inter-domain motions in proteins can mediate fundamental biochemical processes such as signal transduction and allostery. Here we characterize at structural level the inter-domain coupling in a multidomain enzyme, Adenylate Kinase (AK), using ...
Santiago Esteban-Martín +7 more
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Conformational dynamics of a ligand-free adenylate kinase. [PDF]
PLoS ONE, 2013 Adenylate kinase (AdK) is a phosphoryl-transfer enzyme with important physiological functions. Based on a ligand-free open structure and a ligand-bound closed structure solved by crystallography, here we use molecular dynamics simulations to examine the ...
Hyun Deok Song, Fangqiang Zhu
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Calcium-dependent increases in protein kinase-A activity in mouse retinal ganglion cells are mediated by multiple adenylate cyclases. [PDF]
PLoS ONE, 2009 Neurons undergo long term, activity dependent changes that are mediated by activation of second messenger cascades. In particular, calcium-dependent activation of the cyclic-AMP/Protein kinase A signaling cascade has been implicated in several ...
Timothy A Dunn +2 more
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On the Significance of the ADNT1 Carrier in Arabidopsis thaliana under Waterlogging Conditions
Biomolecules, 2023 Among the adenylate carriers identified in Arabidopsis thaliana, only the AMP/ATP transporter ADNT1 shows increased expression in roots under waterlogging stress conditions. Here, we investigated the impact of a reduced expression of ADNT1 in A. thaliana
Roberto Neri-Silva +10 more
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