Adenylate Kinase and Metabolic Signaling in Cancer Cells [PDF]
Frontiers in Oncology, 2020 A hallmark of cancer cells is the ability to rewire their bioenergetics and metabolic signaling circuits to fuel their uncontrolled proliferation and metastasis. Adenylate kinase (AK) is the critical enzyme in the metabolic monitoring of cellular adenine
Aleksandr Klepinin +6 more
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Conformational dynamics of adenylate kinase in crystals [PDF]
Structural DynamicsAdenylate kinase is a ubiquitous enzyme in living systems and undergoes dramatic conformational changes during its catalytic cycle. For these reasons, it is widely studied by genetic, biochemical, and biophysical methods, both experimental and ...
Junhyung Kim +5 more
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Correlated inter-domain motions in adenylate kinase. [PDF]
PLoS Computational Biology, 2014 Correlated inter-domain motions in proteins can mediate fundamental biochemical processes such as signal transduction and allostery. Here we characterize at structural level the inter-domain coupling in a multidomain enzyme, Adenylate Kinase (AK), using ...
Santiago Esteban-Martín +7 more
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Adenylate kinase 1 overexpression increases locomotor activity in medaka fish [PDF]
PLoS ONE, 2022 Maintenance of the energy balance is indispensable for cell survival and function. Adenylate kinase (Ak) is a ubiquitous enzyme highly conserved among many organisms.
Michiyo Maruyama +5 more
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The role of the adenylate kinase 5 gene in various diseases and cancer [PDF]
Journal of Clinical and Translational ScienceAdenylate kinases (AKs) are important enzymes involved in cellular energy metabolism. Among AKs, AK5 (adenylate kinase 5), a cytosolic protein, is emerging as a significant contributor to various diseases and cellular processes. This comprehensive review
M. Sarim Siddiqui +2 more
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Induced-fit movements in adenylate kinases [PDF]
Journal of Molecular Biology, 1990 The high-resolution crystal structures of three homologous adenylate kinases with zero, one and both ( = 2-substrate mimicking inhibitor) bound substrates have been compared. The comparisons are meaningful, because all structures occur in two or three different crystal contact environments indicating that they represent intrinsically stable ...
Schulz, Georg E. +2 more
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Hypoxanthine-Guanine Phosphoribosyltransferase/adenylate Kinase From Zobellia galactanivorans: A Bifunctional Catalyst for the Synthesis of Nucleoside-5′-Mono-, Di- and Triphosphates [PDF]
Frontiers in Bioengineering and Biotechnology, 2020 In our search for novel biocatalysts for the synthesis of nucleic acid derivatives, we found a good candidate in a putative dual-domain hypoxanthine-guanine phosphoribosyltransferase (HGPRT)/adenylate kinase (AMPK) from Zobellia galactanivorans (ZgHGPRT ...
Javier Acosta +9 more
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An Adenylate Kinase OsAK3 Involves Brassinosteroid Signaling and Grain Length in Rice (Oryza sativa L.) [PDF]
Rice, 2021 Background Grain size is one of the major determinants of cereal crop yield. As a class of plant polyhydroxysteroids, brassinosteroids (BRs) play essential roles in the regulation of grain size and plant architecture in rice.
Jiaqi Zhang +8 more
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Identification of novel DNA hypermethylation of the adenylate kinase 5 promoter in colorectal adenocarcinoma [PDF]
Scientific Reports, 2021 Adenylate kinase 5 (AK5) belongs to the adenylate kinase family that catalyses reversible phosphate transfer between adenine nucleotides, and it is related to various energetic signalling mechanisms.
Bokyung Ahn +6 more
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Subtle Role for Adenylate Kinase 1 in Maintaining Normal Basal Contractile Function and Metabolism in the Murine Heart [PDF]
Frontiers in Physiology, 2021 AimsAdenylate kinase 1 (AK1) catalyses the reaction 2ADP ↔ ATP + AMP, extracting extra energy under metabolic stress and promoting energetic homeostasis.
Sevasti Zervou +20 more
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