Anthrax edema toxin modulates PKA- and CREB-dependent signaling in two phases.
PLoS ONE, 2008 BackgroundAnthrax edema toxin (EdTx) is an adenylate cyclase which operates in the perinuclear region of host cells. However, the action of EdTx is poorly understood, especially at molecular level. The ability of EdTx to modulate cAMP-dependent signaling
Andrea Puhar +4 more
doaj +1 more source
Carbachol and bradykinin elevate cyclic AMP and rapidly deplete ATP in cultured rat sympathetic neurons [PDF]
, 1991 The agonists carbachol (CCh) and bradykinin (BK) and 54 mM KCl (high K+) were among the most potent stimulants of cyclic AMP (cAMP) production in cultured rat sympathetic neurons, measured with the use of a high-fidelity assay developed for small samples.
Murrell, R D +2 more
core +3 more sources
Neuropathogenic role of adenylate kinase-1 in Aβ-mediated tau phosphorylation via AMPK and GSK3β.
Human Molecular Genetics, 2012 Abnormally hyperphosphorylated tau is often caused by tau kinases, such as GSK3β and Cdk5. Such occurrence leads to neurofibrillary tangle formation and neuronal degeneration in tauopathy, including Alzheimer's disease (AD).
Hyejin Park +7 more
semanticscholar +1 more source
Growth Hormone (GH)-Releasing Peptide Stimulation of GH Release from Human Somatotroph Adenoma Cells: Interaction with GH-Releasing Hormone, Thyrotropin- Releasing Hormone, and Octreotide. [PDF]
, 1994 The synthetic hexapeptide GH-releasing peptide (GHRP; His-D-Trp-Ala-Trp-D-Phe-Lys-NH2) specifically stimulates GH secretion in humans in vivo and in animals in vitro and in vivo via a still unknown receptor and mechanism.
Brockmeier, S. +7 more
core +1 more source
Molecules, 2018 Multi-drug resistant microorganism infections with emerging problems that require not only a prevention strategy, but also the development of new inhibitory compounds.
Mihaela Ileana Ionescu, Ovidiu Oniga
doaj +1 more source
, 2004 Complementary (antisense) peptide mini-receptor inhibitors are complementary peptides designed to be receptor-surrogates that act by binding to selected surface features of biologically important proteins thereby inhibiting protein-cognate receptor ...
Bhakoo, Ashish +4 more
core +1 more source
Cannabinoid signalling in TNF-alpha induced IL-8 release [PDF]
, 2006 Original article can be found at: http://www.sciencedirect.com/science/journal/00142999 Copyright Elsevier B.V.
Baydoun, A. R. +4 more
core +1 more source
Identification of a novel motif in DNA ligases exemplified by DNA ligase IV [PDF]
, 2006 DNA ligase IV is an essential protein that functions in DNA non-homologous end-joining, the major mechanism that rejoins DNA double-strand breaks in mammalian cells. LIG4 syndrome represents a human disorder caused by mutations in DNA ligase IV that lead
Doherty, Aidan J +5 more
core +1 more source
Cytokine regulation of adenylate cyclase activity in LLC-PK1 cells [PDF]
, 1992 Cytokine regulation of adenylate cyclase activity in LLC-PK1 cells. Although several cytokines have been demonstrated to exert pleiotropic responses, there is little information on cytokine regulation of renal tubular epithelial cell function.
Abraham +47 more
core +1 more source
Functional Dynamics in the Enzyme Adenylate Kinase [PDF]
Biophysical Journal, 2010 An important question in biology is how the energy landscape of enzymes can enable efficient catalysis of chemical reactions. We have undertaken an in-depth analysis of conformational exchange dynamics in the enzyme adenylate kinase (adk). Adk is an essential enzyme in higher organisms that catalyzes the reversible interconversion of AMP and ATP into ...
openaire +2 more sources