Results 111 to 120 of about 76,182 (200)

Adenylate kinase 9 is essential for sperm function and male fertility in mammals. [PDF]

Proc Natl Acad Sci U S A, 2023
O'Callaghan E, Navarrete-Lopez P, Štiavnická M, Sánchez JM, Maroto M, Pericuesta E, Fernández-González R, O'Meara C, Eivers B, Kelleher MM, Evans RD, Mapel XM, Lloret-Villas A, Pausch H, Balastegui-Alarcón M, Avilés M, Sanchez-Rodriguez A, Roldan ERS, McDonald M, Kenny DA, Fair S, Gutiérrez-Adán A, Lonergan P.   +22 more
europepmc   +1 more source

Depleted Energy Charge and Increased Pulmonary Endothelial Permeability Induced by Mitochondrial Complex I inhibition are Mitigated by Coenzyme Q\u3csub\u3e1\u3c/sub\u3e in the Isolated Perfused Rat Lung [PDF]

, 2013
Mitochondrial dysfunction is associated with various forms of lung injury and disease that also involve alterations in pulmonary endothelial permeability, but the relationship, if any, between the two is not well understood.
Audi, Said H., Bongard, Robert D, Hoffmann, Raymond G., Lindemer, Brian J, Merker, Marilyn P., Townsley, Mary I., Yan, Ke, Zhang, Xiao   +7 more
core   +1 more source

Transfer RNA and small molecule therapeutics for aminoacyl‐tRNA synthetase diseases

The FEBS Journal, EarlyView.
Aminoacyl‐tRNA synthetases catalyze the ligation of a specific amino acid to a cognate tRNA—a reaction that lays the foundations for deciphering the genetic code. Pathogenic alleles in these synthetases can lead to dominant or recessive disorders, for which little or no disease‐specific treatments exist.
Tristan N. Samuels, Fanqi Wu, Maria Mahmood, Wajd A. Abuzaid, Nancy Sun, Angelica Moresco, Victoria M. Siu, Patrick O'Donoghue, Ilka U. Heinemann   +8 more
wiley   +1 more source

Anti-adenylate kinase 5 encephalitis: Clinical characteristics, diagnosis, and management of this rare entity. [PDF]

J Transl Autoimmun, 2023
Li EC, Lai QL, Cai MT, Fang GL, Shen CH, Ding MP, Zhang YX.   +6 more
europepmc   +1 more source

Path Similarity Analysis: a Method for Quantifying Macromolecular Pathways

, 2015
Diverse classes of proteins function through large-scale conformational changes; sophisticated enhanced sampling methods have been proposed to generate these macromolecular transition paths. As such paths are curves in a high-dimensional space, they have
Beckstein, Oliver, Kumar, Avishek, Seyler, Sean L., Thorpe, Michael F.   +3 more
core   +2 more sources

PI5P4K inhibitors: promising opportunities and challenges

The FEBS Journal, EarlyView.
Developing inhibitors is like climbing a steep, challenging mountain. PI5P4K inhibitors hold significant promise for the treatment of cancer, immune disorders, and neurological diseases. However, the path to success is fraught with hurdles, and researchers are therefore required to apply their expertise to overcome critical “checkpoints.” While some ...
Koh Takeuchi, Lisa Nagase, Shun Kageyama, Hirotaka Kanoh, Masashi Oshima, Aki Ogawa‐Iio, Yoshiki Ikeda, Yuki Fujii, Sei Kondo, Natsuki Osaka, Takeshi Masuda, Tsukasa Ishihara, Yoshikazu Nakamura, Yoshihisa Hirota, Takehiko Sasaki, Toshiya Senda, Atsuo T. Sasaki   +16 more
wiley   +1 more source

Adenylate kinase 2 is a biomarker related to the prognosis of glioma and the immune microenvironment. [PDF]

J Clin Lab Anal, 2023
Liu Z, Tang C, Teng X, Mohamed ZA, Fan J.   +4 more
europepmc   +1 more source

Measuring catalytic mechanism similarity – a new approach to study enzyme function and evolution

The FEBS Journal, EarlyView.
We introduce a previously undescribed computational method to measure the similarity of enzyme mechanisms, enabling comparison of catalytic steps across hundreds of enzymes. Applying this method to a database of enzyme mechanisms demonstrated its ability to automatically uncover functional and evolutionary relationships, independently of sequence and ...
Antonio J. M. Ribeiro, Ioannis G. Riziotis, Neera Borkakoti, Pedro A. Fernandes, Maria J. Ramos, Janet M. Thornton   +5 more
wiley   +1 more source

Insights into Enzymatic Catalysis from Binding and Hydrolysis of Diadenosine Tetraphosphate by E. coli Adenylate Kinase. [PDF]

Biochemistry, 2023
Tischlik S, Oelker M, Rogne P, Sauer-Eriksson AE, Drescher M, Wolf-Watz M.   +5 more
europepmc   +1 more source

Mechanistic Basis for a Connection between the Catalytic Step and Slow Opening Dynamics of Adenylate Kinase. [PDF]

J Chem Inf Model, 2023
Dulko-Smith B, Ojeda-May P, Ådén J, Wolf-Watz M, Nam K.   +4 more
europepmc   +1 more source