Results 141 to 150 of about 76,182 (200)

Experimental approaches to understanding the role of protein phosphorylation in the regulation of neuronal function [PDF]

, 1983
Studies by Earl Sutherland and his colleagues on hormonal regulation of the breakdown of glycogen in liver resulted in the discovery that the first step in the action of many hormones is to increase the synthesis of cAMP by activating adenylate cyclase ...
Kennedy, Mary B.
core  

Neutrophil responses to CRP are not dependent on polymorphism of human FcgammaRIIA (R131H).

, 2004
IgG2a mediated in vitro phagocytosis is less effective for individuals homozygous for Fcgamma RIIaR131 allele and such individuals are also more susceptible to certain infections.
Bodman-Smith, KB, Raynes, JG, Rodríguez, JA   +2 more
core   +2 more sources

BioSpring: An elastic network framework for interactive exploration of macromolecular mechanics

Protein Science, Volume 34, Issue 5, May 2025.
Abstract BioSpring is an innovative tool for interactive molecular modeling and simulation, designed to explore the dynamics of biological structures in real time. Using an augmented elastic network model, the BioSpring framework enables researchers to intuitively examine complex biomolecules, and it combines real‐time feedback with the user's ...
Benoist Laurent, André Lanrezac, Hubert Santuz, Nicolas Ferey, Olivier Delalande, Marc Baaden   +5 more
wiley   +1 more source

SPOC domain-containing protein 1 regulates the proliferation and apoptosis of human spermatogonial stem cells through adenylate kinase 4. [PDF]

World J Stem Cells, 2022
Zhou D, Zhu F, Huang ZH, Zhang H, Fan LQ, Fan JY.   +5 more
europepmc   +1 more source

Kisspeptin fiber and receptor distribution analysis suggests its potential role in central sensorial processing and behavioral state control

Journal of Neuroendocrinology, Volume 37, Issue 5, May 2025.
Abstract Kisspeptin (KP) signaling in the brain is defined by the anatomical distribution of KP‐producing neurons, their fibers, receptors, and connectivity. Technological advances have prompted a re‐evaluation of these chemoanatomical aspects, originally studied in the early years after the discovery of KP and its receptor Kiss1r.
Limei Zhang, Vito Salvador Hernández, Mario Alberto Zetter, Oscar Rene Hernández‐Pérez, Rafael Hernández‐González, Ignacio Camacho‐Arroyo, Lee E. Eiden, Robert P. Millar   +7 more
wiley   +1 more source

Tracking the ATP-binding response in adenylate kinase in real time. [PDF]

Sci Adv, 2021
Orädd F, Ravishankar H, Goodman J, Rogne P, Backman L, Duelli A, Nors Pedersen M, Levantino M, Wulff M, Wolf-Watz M, Andersson M.   +10 more
europepmc   +1 more source

Functional and Pangenomic Exploration of Roc Two‐Component Regulatory Systems Identifies Novel Players Across Pseudomonas Species

Molecular Microbiology, Volume 123, Issue 5, Page 439-453, May 2025.
The Roc system represents a highly interconnected but incomplete network of two‐component regulatory systems involved in the virulence of Pseudomonas aeruginosa. Our work has enabled us to identify the missing RocA3 regulator, to propose new players in the system and to delineate their conservation between clades of the species.
Victor Simon, Julian Trouillon, Ina Attrée, Sylvie Elsen   +3 more
wiley   +1 more source

Adenylate Kinase Isozyme 3 Regulates Mitochondrial Energy Metabolism and Knockout Alters HeLa Cell Metabolism. [PDF]

Int J Mol Sci, 2022
Fujisawa K, Wakazaki M, Matsuzaki A, Matsumoto T, Yamamoto N, Noma T, Takami T.   +6 more
europepmc   +1 more source

Transcriptional Tuning: How Auxin Strikes Unique Chords in Gene Regulation

Physiologia Plantarum, Volume 177, Issue 3, May/June 2025.
Abstract Auxin is a central regulator of plant growth, development, and responses to environmental cues. How a single phytohormone mediates such a diverse array of developmental responses has remained a longstanding question in plant biology. Somehow, perception of the same auxin signal can lead to divergent responses in different organs, tissues, and ...
Joseph S. Taylor, Bastiaan O. R. Bargmann   +1 more
wiley   +1 more source

Intracellular Sphingosine‐1‐Phosphate Induces Lipolysis Through Direct Activation of Protein Kinase C Zeta

The FASEB Journal, Volume 39, Issue 7, 15 April 2025.
We have identified intracellular S1P as a direct activator of PKC zeta, leading to potent activation of lipolysis in 3T3‐L1 and primary adipocytes in vitro, while inhibition of S1P degradation by blocking S1P lyase through VD‐78 further enhances this effect.
Sarah Weske, Melissa Kim Nowak, Alex Zaufel, Lea Esser, Christoph Peter, Lisa Walz, Helena Kühn, Tsyon Wolde, Julia Hoppe, Nathalie Hannelore Schröder, Tobias Buschmann, Philipp Wollnitzke, Bodo Levkau   +12 more
wiley   +1 more source