Results 171 to 180 of about 86,186 (304)

Substrate‐binding and catalytic roles of Lys194 in the C‐terminus in human adenylate kinase by site‐directed random mutagenesis [PDF]

open access: bronze, 1997
Takanori Ayabe   +6 more
openalex   +1 more source

Plasma proteomic profiling and molecular clustering reveal immune‐defined prognostic subtypes in lung adenocarcinoma

open access: yesInternational Journal of Cancer, Volume 158, Issue 4, Page 858-865, 15 February 2026.
What's new? Lung adenocarcinoma shows considerable heterogeneity in disease progression and therapeutic response. Here, the authors analyzed tumor samples through proteomic profiling and applied network‐based clustering. They identified two distinct patient groups with different demographic, clinical, and molecular characteristics.
Ujjwal Neogi   +10 more
wiley   +1 more source

Adenylate kinase 5 (AK5) autoimmune encephalitis: Clinical presentations and outcomes in three new patients. [PDF]

open access: yesJ Neuroimmunol, 2022
McKeon-Makki I   +7 more
europepmc   +1 more source

Iterative Modeling via Structural Diffusion (IMSD): Exploring Fold‐Switching Pathways in Metamorphic Proteins Using AlphaFold2‐Based Generative Diffusion Model UFConf

open access: yesProteins: Structure, Function, and Bioinformatics, Volume 94, Issue 2, Page 633-648, February 2026.
ABSTRACT Metamorphic proteins (MPs) can fold into two or more distinct spatial structures. Increasing interest in MPs has spurred the search for computational tools to predict proteins fold‐switching potential and model their refolding pathways. Here we address this problem by using the recently reported generative diffusion predictor UFConf, based on ...
Dmitrii A. Luzik, Nikolai R. Skrynnikov
wiley   +1 more source

NMNAT1 Activates Autophagy to Delay D‐Galactose‐Induced Aging in Cochlear Hair Cells

open access: yesAging Cell, Volume 25, Issue 2, February 2026.
The study presents mechanistic insights into cochlear hair cells aging using cellular and explant models. The assessment into NMNAT1 regulated NAD+ metabolism, autophagy, and aging in ARHL. NMNAT1 overexpression restores autophagic activity and decelerates aging in cochlear hair cells.
Yongjie Wei   +14 more
wiley   +1 more source

Lycium barbarum polysaccharides enhance testicular spermatogenesis in d‐galactose‐induced aging rats via calcium signaling

open access: yesAndrology, Volume 14, Issue 2, Page 496-515, February 2026.
Abstract Background Lycium barbarum polysaccharide (LBP) has long been recognized as having a wide range of beneficial properties for improving proliferation. However, the protective effects and specific mechanisms of d‐galactose‐induced testicular dysfunction in reproductively senescent rats are not fully understood.
Wenxin Ma   +8 more
wiley   +1 more source

Tracking the ATP-binding response in adenylate kinase in real time. [PDF]

open access: yesSci Adv, 2021
Orädd F   +10 more
europepmc   +1 more source

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