Results 11 to 20 of about 76,182 (200)

Conformational dynamics of adenylate kinase in crystals [PDF]

Structural Dynamics
Adenylate kinase is a ubiquitous enzyme in living systems and undergoes dramatic conformational changes during its catalytic cycle. For these reasons, it is widely studied by genetic, biochemical, and biophysical methods, both experimental and ...
Junhyung Kim, Sojin Moon, Tod D. Romo, Yifei Yang, Euiyoung Bae, George N. Phillips Jr.   +5 more
doaj   +2 more sources

The role of the adenylate kinase 5 gene in various diseases and cancer [PDF]

Journal of Clinical and Translational Science
Adenylate kinases (AKs) are important enzymes involved in cellular energy metabolism. Among AKs, AK5 (adenylate kinase 5), a cytosolic protein, is emerging as a significant contributor to various diseases and cellular processes. This comprehensive review
M. Sarim Siddiqui, Mehdi H. Shahi, Javier S. Castresana   +2 more
doaj   +2 more sources

An Adenylate Kinase OsAK3 Involves Brassinosteroid Signaling and Grain Length in Rice (Oryza sativa L.) [PDF]

Rice, 2021
Background Grain size is one of the major determinants of cereal crop yield. As a class of plant polyhydroxysteroids, brassinosteroids (BRs) play essential roles in the regulation of grain size and plant architecture in rice.
Jiaqi Zhang, Xiuying Gao, Guang Cai, Yuji Wang, Jianbo Li, Huaying Du, Ruqin Wang, Hongsheng Zhang, Ji Huang   +8 more
doaj   +2 more sources

Identification of novel DNA hypermethylation of the adenylate kinase 5 promoter in colorectal adenocarcinoma [PDF]

Scientific Reports, 2021
Adenylate kinase 5 (AK5) belongs to the adenylate kinase family that catalyses reversible phosphate transfer between adenine nucleotides, and it is related to various energetic signalling mechanisms.
Bokyung Ahn, Yang Seok Chae, Soo Kyung Lee, Moa Kim, Hyeon Soo Kim, Ji Wook Moon, Sun-Hwa Park   +6 more
doaj   +2 more sources

Subtle Role for Adenylate Kinase 1 in Maintaining Normal Basal Contractile Function and Metabolism in the Murine Heart [PDF]

Frontiers in Physiology, 2021
AimsAdenylate kinase 1 (AK1) catalyses the reaction 2ADP ↔ ATP + AMP, extracting extra energy under metabolic stress and promoting energetic homeostasis.
Sevasti Zervou, Sevasti Zervou, Debra J. McAndrew, Debra J. McAndrew, Hannah J. Whittington, Hannah J. Whittington, Hannah A. Lake, Hannah A. Lake, Kyung Chan Park, Kyung Chan Park, Kyung Chan Park, Kuan Minn Cha, Kuan Minn Cha, Philip J. Ostrowski, Philip J. Ostrowski, Thomas R. Eykyn, Jürgen E. Schneider, Stefan Neubauer, Stefan Neubauer, Craig A. Lygate, Craig A. Lygate   +20 more
doaj   +2 more sources

Host-Induced Gene Silencing of an Adenylate Kinase Gene Involved in Fungal Energy Metabolism Improves Plant Resistance to Verticillium dahliae [PDF]

Biomolecules, 2020
Verticillium wilt, caused by the ascomycete fungus Verticillium dahliae (Vd), is a devastating disease of numerous plant species. However, the pathogenicity/virulence-related genes in this fungus, which may be potential targets for improving plant ...
Xiaofeng Su, Guoqing Lu, Xiaokang Li, Latifur Rehman, Wende Liu, Guoqing Sun, Huiming Guo, Guoliang Wang, Hongmei Cheng   +8 more
doaj   +2 more sources

A Convenient, Rapid, Sensitive, and Reliable Spectrophotometric Assay for Adenylate Kinase Activity [PDF]

Molecules, 2019
Enzymatic activity assays are essential and critical for the study of enzyme kinetics. Adenylate kinase (Adk) plays a fundamental role in cellular energy and nucleotide homeostasis.
Kai Song, Yejing Wang, Yu Li, Chaoxiang Ding, Rui Cai, Gang Tao, Ping Zhao, Qingyou Xia, Huawei He   +8 more
doaj   +2 more sources

PAF‐induced inflammatory and immuno‐allergic ophthalmic diseases and their mitigation with PAF receptor antagonists: Cell and nuclear effects

BioFactors, Volume 48, Issue 6, Page 1226-1249, November/December 2022., 2022
Abstract Ocular allergies are becoming more prevalent as more airborne pollutants, irritants and microbes pervade our environment. Inflammatory and allergic mediators released by dendritic and mast cells within the conjunctiva cause allergic conjunctivitis (AC), a prevalent ocular surface disorder that affects >40% of the world's human population on a ...
Najam A. Sharif
wiley   +1 more source

Proteomic profiling of impaired excitation–contraction coupling and abnormal calcium handling in muscular dystrophy

PROTEOMICS, Volume 22, Issue 23-24, December 2022., 2022
Abstract The X‐linked inherited neuromuscular disorder Duchenne muscular dystrophy is characterised by primary abnormalities in the membrane cytoskeletal component dystrophin. The almost complete absence of the Dp427‐M isoform of dystrophin in skeletal muscles renders contractile fibres more susceptible to progressive degeneration and a leaky ...
Paul Dowling, Stephen Gargan, Dieter Swandulla, Kay Ohlendieck   +3 more
wiley   +1 more source

Measuring the tail: Methods for poly(A) tail profiling

WIREs RNA, Volume 14, Issue 1, January/February 2023., 2023
A development of the methods used to study the length and composition of poly(A) tails, uncovering the 3′‐end tailing as a much more complex and impactful process than previously thought. Abstract The 3′‐end poly(A) tail is an important and potent feature of most mRNA molecules that affects mRNA fate and translation efficiency.
Aleksandra Brouze, Paweł Szczepan Krawczyk, Andrzej Dziembowski, Seweryn Mroczek   +3 more
wiley   +1 more source