Results 11 to 20 of about 945,743 (288)
Conformational dynamics of a ligand-free adenylate kinase. [PDF]
PLoS ONE, 2013 Adenylate kinase (AdK) is a phosphoryl-transfer enzyme with important physiological functions. Based on a ligand-free open structure and a ligand-bound closed structure solved by crystallography, here we use molecular dynamics simulations to examine the ...
Hyun Deok Song, Fangqiang Zhu
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Coupled ATPase-adenylate kinase activity in ABC transporters
Nature Communications, 2016 ATP-binding cassette (ABC) transporters hydrolyse ATP to transport molecules across the cell membrane. Here Vogelet al. show that the ABC exporter MsBA can couple ATP hydrolyse to an adenylate kinase activity that seems to be predominant at low ATP ...
Hundeep Kaur +5 more
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Nature Communications, 2017 Targeting the specific metabolic phenotypes of colorectal cancer stem cells (CRCSCs) is a potential therapeutic strategy for colorectal cancer (CRC). Here, the authors show that adenylate kinase hCINAP is overexpressed in CRC, binds to the C-terminal ...
Yapeng Ji +9 more
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RNA mimicry by the fap7 adenylate kinase in ribosome biogenesis.
PLoS Biology, 2014 During biogenesis of the 40S and 60S ribosomal subunits, the pre-40S particles are exported to the cytoplasm prior to final cleavage of the 20S pre-rRNA to mature 18S rRNA. Amongst the factors involved in this maturation step, Fap7 is unusual, as it both
Jérôme Loc'h +13 more
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Minimum free energy path of ligand-induced transition in adenylate kinase. [PDF]
PLoS Computational Biology, 2012 Large-scale conformational changes in proteins involve barrier-crossing transitions on the complex free energy surfaces of high-dimensional space. Such rare events cannot be efficiently captured by conventional molecular dynamics simulations.
Yasuhiro Matsunaga +5 more
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PLoS ONE, 2011 BackgroundEnergetic and metabolic circuits that orchestrate cell differentiation are largely unknown. Adenylate kinase (AK) and associated AMP-activated protein kinase (AMPK) constitute a major metabolic signaling axis, yet the role of this system in ...
Petras P Dzeja +4 more
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Molecular and functional characterization of a Trypanosoma cruzi nuclear adenylate kinase isoform. [PDF]
PLoS Neglected Tropical Diseases, 2013 Trypanosoma cruzi, the etiological agent of Chagas' disease, is an early divergent eukaryote in which control of gene expression relies mainly in post-transcriptional mechanisms.
María de los Milagros Cámara +4 more
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Frontiers in Plant Science, 2015 The bulk of ATP synthesis in plants is performed by ATP synthase, the main bioenergetics engine of cells, operating both in mitochondria and in chloroplasts.
Abir U Igamberdiev, Leszek A Kleczkowski
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Role of Repeated Conformational Transitions in Substrate Binding of Adenylate Kinase. [PDF]
J Phys Chem B, 2022 The catalytic cycle of the enzyme adenylate kinase involves large conformational motions between open and closed states. A previous single-molecule experiment showed that substrate binding tends to accelerate both the opening and the closing rates and ...
Lu J, Scheerer D, Haran G, Li W, Wang W.
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Tracking the ATP-binding response in adenylate kinase in real time. [PDF]
Sci Adv, 2021 Time-resolved x-ray solution scattering identifies cooperative structural dynamics in the adenylate kinase enzymatic reaction.
Orädd F +10 more
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