Results 191 to 200 of about 86,186 (304)

Engineering of an Ancestral McbA with Enhanced Domain Mobility Extends Biocatalytic Amide Synthesis Scope

Advanced Synthesis &Catalysis, Volume 368, Issue 2, January 2026.
We show how engineered ancestral amide bond synthetases (ABSs) together with cofactor recycling using a single polyphosphate kinase paves the way for chemoenzymatic synthesis of pharmacophores. The figure illustrates how ancestral ABS has a more flexible C‐terminal domain, which is associated with enhanced catalytic performance and expanded amine scope.
Elisabeth Söderberg, Marianne R. Molenaar, Katarzyna Zaczyk, Magnus Johansson, Martin A. Hayes, Per‐Olof Syrén   +5 more
wiley   +1 more source

Type II Alveolar Epithelial Cells Promote Sepsis‐Induced Immunosuppression in Alveolar Macrophages via Exosomal lncRNA Rmrp Release

Advanced Science, Volume 13, Issue 1, 5 January 2026.
The S100A4/STAT3 axis promotes Rmrp transcription in AEC‐IIs and Rmrp expression in AEC‐II‐derived exosomes. Upon entry into AMs, Rmrp binds to and blocks the ubiquitination and degradation of ZFP36. Increased ZFP36 induced Pfkfb3 mRNA decay by binding to AREs in the 3′ UTR, curbing glycolysis and immune responses of AMs and aggravating SII and ...
Chengxi Liu, Weixia Xuan, Song Cao, Huayun Jia, Qian Wu, Xiaowu Tan, Qijie Wang, Xiaojun Li, Lisha Ding, Yaru Xiong, Meiyun Zhao, Longcheng Zheng, Yunzhu Xi, Jianhua Tan, Rong Li, Xulong Zhang, Wenjie Liu, Xu Wu   +17 more
wiley   +1 more source

Adenylate kinase 2 expression and addiction in T-ALL. [PDF]

Blood Adv, 2021
Maslah N, Latiri M, Asnafi V, Féroul M, Bedjaoui N, Steimlé T, Six E, Verhoyen E, Macintyre E, Lagresle-Peyrou C, Lhermitte L, Andrieu GP.   +11 more
europepmc   +1 more source

Adenylate kinase, ATP phosphohydrolase and glyceraldehydephosphate dehydrogenase activities in the normal human skin and in some papulosquamous diseases of the skin

, 1973
H. Hammar
openalex   +2 more sources

Modulation of Functionally Significant Conformational Equilibria in Adenylate Kinase by High Concentrations of Trimethylamine Oxide Attributed to Volume Exclusion [PDF]

, 2011
Sureshbabu Nagarajan, Dan Amir, Asaf Grupi, David P. Goldenberg, Allen P. Minton, Elisha Haas   +5 more
openalex   +1 more source

Microglial Deletion of Hrh4 Alleviates Alzheimer's Disease Pathologies by Enhancing Microglial Phagocytosis of Amyloid‐β and Tau

Advanced Science, Volume 13, Issue 2, 9 January 2026.
Histamine H4 receptor (H4R) antagonist VUF6002 mimics low‐dose X‐ray irradiation in aged Alzheimer's disease (AD) mice, enhancing microglial clearance of amyloid‐beta/hyperphosphorylated tau aggregates and restoring cognition. Microglial H4R deletion activates cAMP/TGF‐β1/Smad3 pathway, enhancing phagocytosis, while TGF‐β receptor 1 deletion abolishes ...
Yi‐Jun Xu, Tan Wu, Larry Tso‐Lun Lo, Chi‐Chiu Ko, Xin Wang, Chi Him Eddie Ma   +5 more
wiley   +1 more source

Primed to Burst: Corepressors Coordinate Transcriptional Activation and Efficient Switching Between Cell States

BioEssays, Volume 48, Issue 1, January 2026.
We hypothesize that the TPL corepressor (and likely others) acts as a transcriptional linchpin, stabilizing a state similar yet distinct from the metazoan paused state by recruiting Mediator and other components needed to initiate and coordinate transcriptional bursts across multiple genes.
Alexander R. Leydon, Jennifer L. Nemhauser   +1 more
wiley   +1 more source

Contraction-mediated phosphorylation of AMPK is lower in skeletal muscle of adenylate kinase-deficient mice

, 2005
Chad R. Hancock, Edwin Janssen, Ronald L. Terjung   +2 more
openalex   +1 more source

Adenylate Kinase-Catalyzed Reaction of AMP in Pieces: Enzyme Activation for Phosphoryl Transfer to Phosphite Dianion. [PDF]

Biochemistry, 2021
Fernandez PL, Richard JP.
europepmc   +1 more source

Insights into the evolution of enzymatic specificity and catalysis: From Asgard archaea to human adenylate kinases

, 2022
Apoorva Verma, Emma Åberg-Zingmark, Tobias Sparrman, Ameeq Ul Mushtaq, Per Rogne, Christin Grundström, Ronnie P.‐A. Berntsson, Uwe H. Sauer, Lars Backman, Kwangho Nam, A.E. Sauer-Eriksson, Magnus Wolf‐Watz   +11 more
openalex   +1 more source