Results 241 to 250 of about 945,743 (288)
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Tissue Determined Variations of Adenylate Kinase
Nature, 1968GENETICALLY determined isoenzymes of human erythrocyte adenylate kinase (AK), ATP : AMP phosphotransferase E.C. 2.7.4.3, have been reported1,2. We have characterized several forms of AK in different organs of Wistar rats, employing a mixed agarose-acrylamide gel electrophoresis3. The electrophoretic behaviour of AK was studied in tissues taken from the
Jean Klethi, Paul Mandel
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The development of adenylate kinase in rat liver
Biochimica et Biophysica Acta (BBA) - General Subjects, 1971Abstract The development of adenylate kinase (ATP: AMP phosphotransferase, EC 2.7.4.3) has been studied in rat liver, in the cytosol compartment and in the mitochondria, from 8 days before birth to the adult age. The activity of both compartments increased about 10-fold over the period investigated.
A.R. Richters, F.A. Hommes, A. Beere
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1973
Publisher Summary This chapter describes adenylate kinase and discusses the studies analyzing this enzyme. Adenylate kinase from rabbit muscle was originally purified to a considerable extent by Colowick and Kalckar by taking advantage of its remarkable acid and heat stability.
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Publisher Summary This chapter describes adenylate kinase and discusses the studies analyzing this enzyme. Adenylate kinase from rabbit muscle was originally purified to a considerable extent by Colowick and Kalckar by taking advantage of its remarkable acid and heat stability.
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Isoenzymes of adenylate kinase in human tissue
Biochimica et Biophysica Acta (BBA) - Enzymology, 1972Abstract A study of the isoenzymes of adenylate kinases (ATP:AMP phosphotransferases EC 2.7.4.3) from several tissues of human and rabbit indicated that there is a minimum of two sets of isoenzymes within an individual. Isoenzyme sets were distinguished by differences in inhibitions by AgNO3 and an antiserum against rabbit muscle adenylate kinase ...
Percy J. Russell, John C. Khoo
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Modulation of a pre-existing conformational equilibrium tunes adenylate kinase activity.
Journal of the American Chemical Society, 2012Structural plasticity is often required for distinct microscopic steps during enzymatic reaction cycles. Adenylate kinase from Escherichia coli (AK(eco)) populates two major conformations in solution; the open (inactive) and closed (active) state, and ...
Jörgen Ådén +3 more
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Noncooperative Folding of Subdomains in Adenylate Kinase
Biochemistry, 2009Conformational change is regulating the biological activity of a large number of proteins and enzymes. Efforts in structural biology have provided molecular descriptions of the interactions that stabilize the stable ground states on the reaction trajectories during conformational change.
Magnus Wolf-Watz +5 more
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The structure of a trimeric archaeal adenylate kinase
Journal of Molecular Biology, 1998The adenylate kinase from the hyperthermophilic archaean species Sulfolobus acidocaldarius has been cloned, expressed in Escherichia coli, purified and crystallized. The crystal structure was elucidated by multiple isomorphous replacement and non-crystallographic density averaging. The structure was refined at 2.6 A (1 A=0.1 nm) resolution.
Günter Schäfer +3 more
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Journal of Physical Chemistry B, 2012
During allosteric motions proteins navigate rugged energy landscapes. Hence, mapping of these multidimensional landscapes into lower dimensional manifolds is important for gaining deeper insights into allosteric dynamics.
D. Potoyan +2 more
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During allosteric motions proteins navigate rugged energy landscapes. Hence, mapping of these multidimensional landscapes into lower dimensional manifolds is important for gaining deeper insights into allosteric dynamics.
D. Potoyan +2 more
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Isolation and properties of lens adenylate kinase
Experimental Eye Research, 1968Adenylate kinase was purified 17,000 times from calf lenses. The enzyme activity gradually lowers towards the center of the lens. The properties of the lens enzyme resemble those of the muscle enzyme more than those of the liver enzyme. Lens adenylate kinase has a strict specifity for adenylic nucleotides.
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Adenylate kinase deficiency and malignant hyperthermia
Human Genetics, 1981In a report of two patients who died of malignant hyperthermia, muscle adenylate kinase deficiency was identified in the father and brother of the deceased. To determine if this enzyme deficiency was a biochemical marker for susceptibility to malignant hyperthermia, we measured adenylate kinase in muscle of three survivors of malignant hyperthermia (MH)
D. S. Wood +3 more
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