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Adenylate kinase deficiency and malignant hyperthermia
Human Genetics, 1981In a report of two patients who died of malignant hyperthermia, muscle adenylate kinase deficiency was identified in the father and brother of the deceased. To determine if this enzyme deficiency was a biochemical marker for susceptibility to malignant hyperthermia, we measured adenylate kinase in muscle of three survivors of malignant hyperthermia (MH)
C G, Cerri +3 more
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Two conformations of crystalline adenylate kinase
Journal of Molecular Biology, 1977Abstract Pig muscle adenylate kinase (EC2.7.4.3) can exist in three crystal forms, which are interconvertible. For crystal form A the enzyme structure is known in atomic detail. We report the X-ray diffraction analysis of crystal form B at 4.7 A resolution and a comparison with the A form.
Sachsenheimer, W., Schulz, G.
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Adenylate kinase 2, a mitochondrial enzyme
Biochemical Genetics, 1977The subcellular compartmentalization of the isoenzymes of ATP:AMP phosphotransferase (adenylate kinase) was analyzed in HeLa cells, RAG cells, and RAG-human hybrids that express human AK-2. In HeLa cells and in the hybrids, human AK-2 was present in a mitochemical fraction prepared from cell extracts and in mitochondria purified by density gradient ...
G A, Bruns, V M, Regina
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[Adenylate kinase of plants. Properties of adenylate kinase of pea leaves].
Biokhimiia (Moscow, Russia), 1977The properties of adenylate kinase in 2 ADP in equilibrium ATP + AMP reaction have been studied. The dependence of the enzyme activity on medium pH, protein concentration, substrates, Mg++ ions, AMP, adenine and adenosine has been also investigated. pH optimum is found to be 8.5 for forward reaction and 8-9--for the reverse one. The Michaelis constants
M A, Rodionova +2 more
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Adenylate kinase isoenzymes inAspergillus nidulans
FEMS Microbiology Letters, 1991Adenylate kinase isoenzymes localised in the mitochondria and in the cytosol have been detected in extracts of glucose-grown Aspergillus nidulans using specific staining after electrophoresis on cellulose acetate. The isoenzymes have similar Km values for AMP, ADP and MgATP2- but may differ in the mechanism used for internucleotide phosphate transfer.
V Q, Hoang, W, Jaklitsch, M C, Scrutton
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Adenylate kinases from thermosensitive Escherichia coli strains
Journal of Molecular Biology, 1989The adk genes from several thermosensitive (ts) mutants of Escherichia coli were cloned and sequenced. The mutations responsible for the thermolability of the gene product, the enzyme adenylate kinase, were established. From five independently isolated strains analysed, two contain a CCG to TCG transition changing proline 87 to serine (P87S), another ...
Haase, G. +5 more
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A reactive arginine in adenylate kinase
Biochimica et Biophysica Acta (BBA) - Enzymology, 1975Adenylate kinase (ATP:AMP phosphotransferase, EV 2.7.4.3) from pig heart is inactivated by the specific arginyl reagent phenylglyoxal. During inactivation two molecules of phenyglyoxal are incorporated into the protein indicating the modification of one of the 11 arginine residues. The modification of other amino acids is ruled out.
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Properties of human hepatoma adenylate kinases
International Journal of Biochemistry, 1978Abstract 1. 1. Three adenylate kinase isoenzymes, designated AK I, II and III in order of their increasing electrophoretic mobility towards the anode were partially purified from human hepatomas. 2. 2. When AK III was passed through phosphocellulose, multiple forms were again obtained. 3. 3.
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ERYTHROCYTE ADENYLATE-KINASE DEFICIENCY
The Lancet, 1969A, Szeinberg, S, Gavendo, D, Cahane
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