Potential and limitations of PKA/ PKG inhibitors for platelet studies
Platelets, 2022 Cyclic nucleotides (cAMP and cGMP) and corresponding protein kinases, protein kinase A (PKA) and protein kinase G (PKG), are the main intracellular mediators of endothelium-derived platelet inhibitors. Pharmacological PKA/PKG inhibitors are often used to
Valentina Shpakova +3 more
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Pyrophosphate-Dependent ATP Formation from Acetyl Coenzyme A in Syntrophus aciditrophicus, a New Twist on ATP Formation. [PDF]
, 2016 UnlabelledSyntrophus aciditrophicus is a model syntrophic bacterium that degrades key intermediates in anaerobic decomposition, such as benzoate, cyclohexane-1-carboxylate, and certain fatty acids, to acetate when grown with hydrogen-/formate-consuming ...
Erde, Jonathan +17 more
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ADENYLATE KINASE AND MALIGNANT HYPERPYREXIA
British Journal of Anaesthesia, 1982 The isoenzyme pattern and activity of adenylate kinase was studied in muscle and red blood cells from individuals and swine shown to be susceptible to malignant hyperpyraria. No abnormality in adenylate kinase isoenzyme pattern or activity was found.
L.A. Marjanen, Michael A. Denborough
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Oral cancer cells may rewire alternative metabolic pathways to survive from siRNA silencing of metabolic enzymes. [PDF]
, 2014 BackgroundCancer cells may undergo metabolic adaptations that support their growth as well as drug resistance properties. The purpose of this study is to test if oral cancer cells can overcome the metabolic defects introduced by using small interfering ...
Brumbaugh, Jeffrey +8 more
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BMC Microbiology, 2008 Background Thiamine triphosphate (ThTP) exists in most organisms and might play a role in cellular stress responses. In E. coli, ThTP is accumulated in response to amino acid starvation but the mechanism of its synthesis is still a matter of controversy.
Wins Pierre +4 more
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Metabolomic analysis of human oral cancer cells with adenylate kinase 2 or phosphorylate glycerol kinase 1 inhibition. [PDF]
, 2017 The purpose of this study was to use liquid chromatography-mass spectrometry (LC-MS) with XCMS for a quantitative metabolomic analysis of UM1 and UM2 oral cancer cells after knockdown of metabolic enzyme adenylate kinase 2 (AK2) or phosphorylate glycerol
Cheng, Siliangyu +6 more
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Inhibition of Food Intake by PACAP in the Hypothalamic Ventromedial Nuclei is Mediated by NMDA Receptors [PDF]
, 2014 Central injections of pituitary adenylate cyclase-activating polypeptide (PACAP) into the ventromedial nuclei (VMN) of the hypothalamus produce hypophagia that is dependent upon the PAC1 receptor; however, the signaling downstream of this receptor in the
Choi, Sujean +3 more
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Adenylate effects on protein phosphorylation in the interenvelope lumen of pea chloroplasts [PDF]
, 1989 A 64-kilodalton (kDa) protein, situated in the lumen between the inner and outer envelopes of pea (Pisum sativum L.) chloroplasts (Soll and Bennett 1988, Eur. J.
A.M. Edelman +23 more
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Structural relationships in the adenylate kinase family [PDF]
European Journal of Biochemistry, 1986 The sequences of five distantly related adenylate kinases have been aligned. The local conservation of amino acids is discussed in the light of the known three‐dimensional structure of one of the enzymes, the cytosolic isoenzyme 1 (AK1) from porcine muscle. The similarity profile outlines clearly the active site in the cleft of the spatial structure of
Schulz, G. +6 more
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Cofactor engineering improved CALB production in Pichia pastoris through heterologous expression of NADH oxidase and adenylate kinase. [PDF]
PLoS ONE, 2017 The cofactor engineering strategy can relieve the metabolic stress induced by expression of recombinant protein in cellular metabolism related to cofactor and energy reactions.
Charumathi Jayachandran +2 more
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