Inhibition of Food Intake by PACAP in the Hypothalamic Ventromedial Nuclei is Mediated by NMDA Receptors [PDF]
, 2014 Central injections of pituitary adenylate cyclase-activating polypeptide (PACAP) into the ventromedial nuclei (VMN) of the hypothalamus produce hypophagia that is dependent upon the PAC1 receptor; however, the signaling downstream of this receptor in the
Choi, Sujean +3 more
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Purine-Metabolizing Ectoenzymes Control IL-8 Production in Human Colon HT-29 Cells
Mediators of Inflammation, 2014 Interleukin-8 (IL-8) plays key roles in both chronic inflammatory diseases and tumor modulation. We previously observed that IL-8 secretion and function can be modulated by nucleotide (P2) receptors.
Fariborz Bahrami +6 more
doaj +1 more source
Oral cancer cells may rewire alternative metabolic pathways to survive from siRNA silencing of metabolic enzymes. [PDF]
, 2014 BackgroundCancer cells may undergo metabolic adaptations that support their growth as well as drug resistance properties. The purpose of this study is to test if oral cancer cells can overcome the metabolic defects introduced by using small interfering ...
Brumbaugh, Jeffrey +8 more
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Anais da Academia Brasileira de Ciências, 2016 Considering that Alzheimer's disease is a prevalent neurodegenerative disease worldwide, we investigated the activities of three key kinases: creatine kinase, pyruvate kinase and adenylate kinase in the hippocampus and cerebral cortex in Alzheimer's ...
FRANCINE R. IANISKI +6 more
doaj +1 more source
Minimum free energy path of ligand-induced transition in adenylate kinase. [PDF]
PLoS Computational Biology, 2012 Large-scale conformational changes in proteins involve barrier-crossing transitions on the complex free energy surfaces of high-dimensional space. Such rare events cannot be efficiently captured by conventional molecular dynamics simulations.
Yasuhiro Matsunaga +5 more
doaj +1 more source
Linkage between Fitness of Yeast Cells and Adenylate Kinase Catalysis. [PDF]
PLoS ONE, 2016 Enzymes have evolved with highly specific values of their catalytic parameters kcat and KM. This poses fundamental biological questions about the selection pressures responsible for evolutionary tuning of these parameters.
Hasan Tükenmez +4 more
doaj +1 more source
Bacillus anthracis edema factor substrate specificity: evidence for new modes of action [PDF]
, 2012 Since the isolation of Bacillus anthracis exotoxins in the 1960s, the detrimental activity of edema factor (EF) was considered as adenylyl cyclase activity only.
Agrawal +94 more
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Advances in RIPK1 kinase inhibitors
Frontiers in Pharmacology, 2022 Programmed necrosis is a new modulated cell death mode with necrotizing morphological characteristics. Receptor interacting protein 1 (RIPK1) is a critical mediator of the programmed necrosis pathway that is involved in stroke, myocardial infarction ...
Lu Chen +13 more
doaj +1 more source
Primary cilia elongation in response to interleukin-1 mediates the inflammatory response [PDF]
, 2012 Primary cilia are singular, cytoskeletal organelles present in the majority of mammalian cell types where they function as coordinating centres for mechanotransduction, Wnt and hedgehog signalling. The length of the primary cilium is proposed to modulate
A. K. T. Wann +51 more
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A homolog of the vertebrate pituitary adenylate cyclase-activating polypeptide is both necessary and instructive for the rapid formation of associative memory in an invertebrate [PDF]
, 2010 Similar to other invertebrate and vertebrate animals, cAMP dependent signaling cascades are key components of long-term memory (LTM) formation in the snail Lymnaea stagnalis, an established experimental model for studying evolutionarily conserved ...
Kemenes, György +5 more
core +1 more source