Results 41 to 50 of about 945,743 (288)

Microfluidic Detection of Adenylate Kinase as a Cell Damage Biomarker

Chemosensors, 2023
In vitro cell cultures are used as models for drug discovery. The detection of cell damage biomarkers such as adenylate kinase (AK) is often used in drug screening and cell biology experiments.
Cristiana Domingues, Pedro Mendes Fontes, Pedro G. M. Condelipes, Vanda Marques, Marta B. Afonso, Virginia Chu, Cecília M. P. Rodrigues, João Pedro Conde   +7 more
doaj   +1 more source

Purine-Metabolizing Ectoenzymes Control IL-8 Production in Human Colon HT-29 Cells

Mediators of Inflammation, 2014
Interleukin-8 (IL-8) plays key roles in both chronic inflammatory diseases and tumor modulation. We previously observed that IL-8 secretion and function can be modulated by nucleotide (P2) receptors.
Fariborz Bahrami, Filip Kukulski, Joanna Lecka, Alain Tremblay, Julie Pelletier, Liliana Rockenbach, Jean Sévigny   +6 more
doaj   +1 more source

Calcium-dependent increases in protein kinase-A activity in mouse retinal ganglion cells are mediated by multiple adenylate cyclases.

PLoS ONE, 2009
Neurons undergo long term, activity dependent changes that are mediated by activation of second messenger cascades. In particular, calcium-dependent activation of the cyclic-AMP/Protein kinase A signaling cascade has been implicated in several ...
Timothy A Dunn, Daniel R Storm, Marla B Feller   +2 more
doaj   +1 more source

Bacillus anthracis edema factor substrate specificity: evidence for new modes of action [PDF]

, 2012
Since the isolation of Bacillus anthracis exotoxins in the 1960s, the detrimental activity of edema factor (EF) was considered as adenylyl cyclase activity only.
Agrawal, Altaweel, Basler, Bauche, Bell, Benson, Beste, Bock, Bond, Boyd, Bradley, Brown, Burhenne, Carbonetti, Carbonetti, Carson-Walter, Casteel, Christensen, Christensen, Confer, Copsel, Crawford, Crowe, Cunningham, Dalkas, Defer, Deuquet, Ding, Drum, Duesbery, Feld, Firoved, Friedlander, Fu, Fukuhara, Gaion, Gille, Gordon, Göttle, Hammerschmidt, He, Helfman, Hong, Ivarsson, Jernigan, Johnson, Katayama, Katayama, Kaupp, Kintzer, Klimpel, Laine, Larabee, Larabee, Leppla, Liu, Martin Göttle, McDonough, Milne, Mogridge, Mogridge, Newton, Newton, Newton, Newton, Newton, Oncu, O´Brien, Park, Petosa, Pezard, Postea, Puhar, Roland Seifert, Santelli, Scobie, Scobie, Scorpio, Shapiro, Shen, Shirshev, Soelaiman, Stefan Dove, Sun, Tamayo, Taylor, Taylor, Tesmer, Thomas, Tournier, Vitale, Vitale, Vojtova, Yeager, Zong   +94 more
core   +2 more sources

Linkage between Fitness of Yeast Cells and Adenylate Kinase Catalysis. [PDF]

PLoS ONE, 2016
Enzymes have evolved with highly specific values of their catalytic parameters kcat and KM. This poses fundamental biological questions about the selection pressures responsible for evolutionary tuning of these parameters.
Hasan Tükenmez, Helge Magnus Magnussen, Michael Kovermann, Anders Byström, Magnus Wolf-Watz   +4 more
doaj   +1 more source

Amyloid-β peptide absence in short term effects on kinase activity of energy metabolism in mice hippocampus and cerebral cortex

Anais da Academia Brasileira de Ciências, 2016
Considering that Alzheimer's disease is a prevalent neurodegenerative disease worldwide, we investigated the activities of three key kinases: creatine kinase, pyruvate kinase and adenylate kinase in the hippocampus and cerebral cortex in Alzheimer's ...
FRANCINE R. IANISKI, VIRGINIA C. RECH, VIVIAN S.K. NISHIHIRA, CATIANE B. ALVES, MATHEUS D. BALDISSERA, ETHEL A. WILHELM, CRISTIANE LUCHESE   +6 more
doaj   +1 more source

Corrigendum: Adenylate kinase hCINAP determines self-renewal of colorectal cancer stem cells by facilitating LDHA phosphorylation

Nature Communications, 2017
Nature Communications 8: Article number:15308 (2017); Published: 18 May 2017; Updated: 16 June 2017 The original version of this Article contained an error in the spelling of the author Zemin Zhang, which was incorrectly given as Zeming Zhang.
Yapeng Ji, Chuanzhen Yang, Zefang Tang, Yongfeng Yang, Yonglu Tian, H. Yao, Xi Zhu, Zemin Zhang, J. Ji, Xiaofeng Zheng   +9 more
semanticscholar   +1 more source

Advances in RIPK1 kinase inhibitors

Frontiers in Pharmacology, 2022
Programmed necrosis is a new modulated cell death mode with necrotizing morphological characteristics. Receptor interacting protein 1 (RIPK1) is a critical mediator of the programmed necrosis pathway that is involved in stroke, myocardial infarction ...
Lu Chen, Lu Chen, Xiaoqin Zhang, Yaqing Ou, Maoyu Liu, Maoyu Liu, Dongke Yu, Dongke Yu, Zhiheng Song, Lihong Niu, Lijuan Zhang, Lijuan Zhang, Jianyou Shi, Jianyou Shi   +13 more
doaj   +1 more source

Refolding of urea-denatured adenylate kinase [PDF]

Biochemical Journal, 1998
The refolding of urea-denatured adenylate kinase (EC 2.7.4.3) has been followed by formation of the secondary structure, change of surface hydrophobicity and recovery of catalytic activity. During refolding of adenylate kinase with a 20–80-fold dilution of 4 M urea-denatured enzyme at 10 °C, the formation of the secondary structure is a fast process ...
Jun-Mei Zhou, Xiang-rong Sheng, Hong-jie Zhang, Xian-Ming Pan   +3 more
openaire   +3 more sources

Adenylate Kinase in Human Tissues

Journal of Biological Chemistry, 1974
Abstract The organ specificity of human adenylate kinase isoenzymes was established among adenylate kinase isoenzymes of different tissue origins by differences in the degree of inhibitions by sulfhydryl reagents; by differences in isoelectric points; by differences of enzyme distribution patterns; and in some instances by differences in molecular ...
Leonard Goins, Percy J. Russell, David H. Jones, Janet M. Horenstein, Michael Laver   +4 more
openaire   +2 more sources