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Microfluidic Detection of Adenylate Kinase as a Cell Damage Biomarker
In vitro cell cultures are used as models for drug discovery. The detection of cell damage biomarkers such as adenylate kinase (AK) is often used in drug screening and cell biology experiments.
Cristiana Domingues+7 more
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Purine-Metabolizing Ectoenzymes Control IL-8 Production in Human Colon HT-29 Cells
Interleukin-8 (IL-8) plays key roles in both chronic inflammatory diseases and tumor modulation. We previously observed that IL-8 secretion and function can be modulated by nucleotide (P2) receptors.
Fariborz Bahrami+6 more
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Neurons undergo long term, activity dependent changes that are mediated by activation of second messenger cascades. In particular, calcium-dependent activation of the cyclic-AMP/Protein kinase A signaling cascade has been implicated in several ...
Timothy A Dunn+2 more
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Bacillus anthracis edema factor substrate specificity: evidence for new modes of action [PDF]
Since the isolation of Bacillus anthracis exotoxins in the 1960s, the detrimental activity of edema factor (EF) was considered as adenylyl cyclase activity only.
Agrawal+94 more
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Linkage between Fitness of Yeast Cells and Adenylate Kinase Catalysis. [PDF]
Enzymes have evolved with highly specific values of their catalytic parameters kcat and KM. This poses fundamental biological questions about the selection pressures responsible for evolutionary tuning of these parameters.
Hasan Tükenmez+4 more
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Considering that Alzheimer's disease is a prevalent neurodegenerative disease worldwide, we investigated the activities of three key kinases: creatine kinase, pyruvate kinase and adenylate kinase in the hippocampus and cerebral cortex in Alzheimer's ...
FRANCINE R. IANISKI+6 more
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Nature Communications 8: Article number:15308 (2017); Published: 18 May 2017; Updated: 16 June 2017 The original version of this Article contained an error in the spelling of the author Zemin Zhang, which was incorrectly given as Zeming Zhang.
Yapeng Ji+9 more
semanticscholar +1 more source
Advances in RIPK1 kinase inhibitors
Programmed necrosis is a new modulated cell death mode with necrotizing morphological characteristics. Receptor interacting protein 1 (RIPK1) is a critical mediator of the programmed necrosis pathway that is involved in stroke, myocardial infarction ...
Lu Chen+13 more
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Refolding of urea-denatured adenylate kinase [PDF]
The refolding of urea-denatured adenylate kinase (EC 2.7.4.3) has been followed by formation of the secondary structure, change of surface hydrophobicity and recovery of catalytic activity. During refolding of adenylate kinase with a 20–80-fold dilution of 4 M urea-denatured enzyme at 10 °C, the formation of the secondary structure is a fast process ...
Jun-Mei Zhou+3 more
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Adenylate Kinase in Human Tissues
Abstract The organ specificity of human adenylate kinase isoenzymes was established among adenylate kinase isoenzymes of different tissue origins by differences in the degree of inhibitions by sulfhydryl reagents; by differences in isoelectric points; by differences of enzyme distribution patterns; and in some instances by differences in molecular ...
Leonard Goins+4 more
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