Results 51 to 60 of about 76,182 (200)

Rare hereditary nonspherocytic hemolytic anemia caused by a novel homozygous mutation, c.301C > A, (Q101K), in the AK1 gene in an Indian family

BMC Medical Genomics, 2021
Background Adenylate kinase (AK) deficiency is a rare red cell enzymopathy associated with moderate to severe congenital nonspherocytic hemolytic anemia, along with mental and psychomotor retardation (in exceptional cases).
Rashmi Dongerdiye, Abhilasha Sampagar, Rati Devendra, Prashant Warang, Prabhakar Kedar   +4 more
doaj   +1 more source

Identification and Expression Analysis of Adenylate Kinase Gene Family in Potato

Horticulturae, 2023
Adenylate kinase (ADK) is a key enzyme that is widely distributed in animals and plants. It plays an important role in growth and stress response. However, ADK genes in potato (StADK) have been little reported. It is of great significance to identify ADK
Xiang Li, Chengcheng Lyu, Jun Song, Yifei Lu, Fuchun Zeng, Liming Lu, Liqin Li   +6 more
doaj   +1 more source

A cAMP-binding ectoprotein in the yeast Saccharomyces cerevisiae [PDF]

, 1991
tides 10, 593 ...
Achstetter T., Baroni M. D., Behrens M. M., Biilow R., Bregman D. B., Brunton L. L., Cannon J. F., Caras I. W., Caras I. W., Carr S. A., Clegg C., Conzelmann A., Conzelmann A., Corbin J. D., Cross G. A. M., Dallner G., Davitz M. A., Davitz M. A., DeCamilli P., Doering T. L., Edelman A. M., Ferguson M. A. J., Ferguson M. A. J., Ferguson R., Fersht A., Flockart D. A., Gruber W., Hixson C. S., Ishihara M., Jaynes P. K., Johnson K. E., Kamps M. P., Kiibler D., Korc-Grodzicki B., Kunisawa R., Lang B., Lohmann S. M., Lohmann S. M., Low M. G., Low M. G., Matsumoto K., Matsumoto K., Matsumoto K., Matsumoto K., Matsumoto K., Merino A., Mitts M. R., Mostov K. E., Muller G., Muller G., Muller G., Muller G„, Nairn A. C., Nigam S. K., Nigg E. A., Nigg E. A., Olson S., Pall G., Rhee T., Rodel G., Sakar D., Salomon Y., Smith M. E., Srere P. A., Stieger A., Takami N., Thorner J., Toda T., Trams E. G., Uno I., Vai M., Wen T. C., Wingender-Drissen R.   +72 more
core   +3 more sources

Architecture of androgen receptor pathways amplifying glucagon-like peptide-1 insulinotropic action in male pancreatic β cells

Cell Reports, 2023
Summary: Male mice lacking the androgen receptor (AR) in pancreatic β cells exhibit blunted glucose-stimulated insulin secretion (GSIS), leading to hyperglycemia.
Weiwei Xu, M.M. Fahd Qadir, Daniela Nasteska, Paula Mota de Sa, Caroline M. Gorvin, Manuel Blandino-Rosano, Charles R. Evans, Thuong Ho, Evgeniy Potapenko, Rajakrishnan Veluthakal, Fiona B. Ashford, Stavroula Bitsi, Jia Fan, Manika Bhondeley, Kejing Song, Venkata N. Sure, Siva S.V.P. Sakamuri, Lina Schiffer, Wandy Beatty, Rachael Wyatt, Daniel E. Frigo, Xiaowen Liu, Prasad V. Katakam, Wiebke Arlt, Jochen Buck, Lonny R. Levin, Tony Hu, Jay Kolls, Charles F. Burant, Alejandra Tomas, Matthew J. Merrins, Debbie C. Thurmond, Ernesto Bernal-Mizrachi, David J. Hodson, Franck Mauvais-Jarvis   +34 more
doaj  

Activation of Serotonin 5-HT7 Receptors Modulates Hippocampal Synaptic Plasticity by Stimulation of Adenylate Cyclases and Rescues Learning and Behavior in a Mouse Model of Fragile X Syndrome

Frontiers in Molecular Neuroscience, 2018
We have previously demonstrated that activation of serotonin 5-HT7 receptors (5-HT7R) reverses metabotropic glutamate receptor-mediated long term depression (mGluR-LTD) in the hippocampus of wild-type (WT) and Fmr1 Knockout (KO) mice, a model of Fragile ...
Lara Costa, Lara Maria Sardone, Carmela Maria Bonaccorso, Simona D’Antoni, Michela Spatuzza, Walter Gulisano, Maria Rosaria Tropea, Daniela Puzzo, Marcello Leopoldo, Enza Lacivita, Maria Vincenza Catania, Maria Vincenza Catania, Lucia Ciranna   +12 more
doaj   +1 more source

Co‐expression of HSV‐1 ICP34.5 enhances the expression of gene delivered by self‐amplifying RNA and mitigates its immunogenicity

FEBS Open Bio, EarlyView.
ICP34.5 is one of the most important antihost response proteins. The saRNA‐encoding HSV‐1 neurovirulence protein ICP34.5 clearly mediated the eukaryotic initiation factor 2 alpha subunit (eIF2α) dephosphorylation and significant suppression of innate immune responses in vitro, leading to enhanced expression of the saRNA‐encoded gene.
Xuemin Lu, Yabin Wu, Chunye Zhao, Jie Zheng, Shangwu Chen, Yigang Wang, Yulong Xia   +6 more
wiley   +1 more source

Functional modes of proteins are among the most robust ones [PDF]

, 2004
It is shown that a small subset of modes which are likely to be involved in protein functional motions of large amplitude can be determined by retaining the most robust normal modes obtained using different protein models.
A. Atilgan, B. R. Brooks, C. Chennubhotla, G. Li, K. Hinsen, M. Tirion, S. Nicolay, Y. Wu, Y.-H. Sanejouand   +8 more
core   +3 more sources

Serotonergic signals enhanced hamster sperm hyperactivation

The Journal of Reproduction and Development, 2021
In the present study, we investigated the regulatory mechanisms underlying sperm hyperactivation enhanced by 5-hydroxytryptamine (5-HT) in hamsters. First, we examined the types of 5-HT receptors that regulate hyperactivation.
Chiyori SAKAMOTO, Masakatsu FUJINOKI, Masafumi KITAZAWA, Satoshi OBAYASHI   +3 more
doaj   +1 more source

Localized Activation of Bending in Proximal, Medial and Distal Regions of Sea-Urchin Sperm Flagella [PDF]

, 1973
Spermatozoa from the sea urchin, Colobocentrotus atratus, were partially demembranated by extraction with solutions containing Triton X-100 at a concentration which was insufficient to solubilize the membranes completely.
Brokaw, C. J., Gibbons, I. R.
core  

Toward Design Principles for Biomolecular Condensates for Metabolic Pathways

Advanced Biology, EarlyView.
Biomolecular condensates are membrane‐less compartments found through‐out nature which can serve as reaction crucibles for biochemical processes. This review explores the design strategies underlying how condensates can be used in biotechnology to enhance multistep enzyme cascades including enhancement by mass action and substrate channeling, and ...
Alain A.M. André, Nikita Rehnberg, Ankush Garg, Magnus Kjærgaard   +3 more
wiley   +1 more source