Results 51 to 60 of about 945,743 (288)

Interplay between adenylate metabolizing enzymes and AMP‐activated protein kinase

The FEBS Journal, 2018
Purine nucleotides are involved in a variety of cellular functions, such as energy storage and transfer, and signalling, in addition to being the precursors of nucleic acids and cofactors of many biochemical reactions.
M. Camici, S. Allegrini, M. Tozzi
semanticscholar   +1 more source

Modulation of anti-cancer drug sensitivity through the regulation of mitochondrial activity by adenylate kinase 4

Journal of experimental & clinical cancer research : CR, 2016
Adenylate kinase is a key enzyme in the high-energy phosphoryl transfer reaction in living cells. An isoform of this enzyme, adenylate kinase 4 (AK4), is localized in the mitochondrial matrix and is believed to be involved in stress, drug resistance ...
K. Fujisawa, S. Terai, T. Takami, N. Yamamoto, T. Yamasaki, Toshihiko Matsumoto, K. Yamaguchi, Y. Owada, H. Nishina, T. Noma, I. Sakaida   +10 more
semanticscholar   +1 more source

Primary cilia elongation in response to interleukin-1 mediates the inflammatory response [PDF]

, 2012
Primary cilia are singular, cytoskeletal organelles present in the majority of mammalian cell types where they function as coordinating centres for mechanotransduction, Wnt and hedgehog signalling. The length of the primary cilium is proposed to modulate
A. K. T. Wann, AC Lin, AJ Espanol, AM Malone, BD Engel, BK Yoder, CA Dinarello, CG Jensen, CM Asleson, D Qian, DA Lee, E Verghese, E Verghese, EJ Michaud, EM Mokrzan, GJ Pazour, H Tukachinsky, I Memon, J Kim, JA Deane, JL Rosenbaum, JM Neugebauer, K Gardner, KJ Palmer, L Schneider, M Barzi, M Cao, M. M. Knight, MA Lancaster, MB Hovater, N Sharma, P Tummala, PA Lefebvre, PV Tran, RY Kwon, S Abdul-Majeed, S Agarwal, S Kim, S Massinen, S Mukhopadhyay, S Pritchard, S Toffoli, SC Goetz, SM Nauli, SR McGlashan, SR McGlashan, SR McGlashan, TT Chowdhury, TY Besschetnova, Y Chen, Y Ou, YH Choi   +51 more
core   +2 more sources

A homolog of the vertebrate pituitary adenylate cyclase-activating polypeptide is both necessary and instructive for the rapid formation of associative memory in an invertebrate [PDF]

, 2010
Similar to other invertebrate and vertebrate animals, cAMP dependent signaling cascades are key components of long-term memory (LTM) formation in the snail Lymnaea stagnalis, an established experimental model for studying evolutionarily conserved ...
Kemenes, György, Kemenes, Ildikó, László, Zita, Pirger, Zsolt, Reglődi, Dóra, Tóth, Gábor   +5 more
core   +1 more source

Water content, adenylate kinase, and mitochondria drive adenylate balance in dehydrating and imbibing seeds

Journal of Experimental Botany, 2017
AMP accumulation in dry seeds, which powers the rapid resumption of energy flow during imbibition, is driven by dehydration through the interplay between ATP demand, adenylate kinase, and oxidative phosphorylation.
M. Raveneau, A. Benamar, D. Macherel
semanticscholar   +1 more source

Identification and Expression Analysis of Adenylate Kinase Gene Family in Potato

Horticulturae, 2023
Adenylate kinase (ADK) is a key enzyme that is widely distributed in animals and plants. It plays an important role in growth and stress response. However, ADK genes in potato (StADK) have been little reported. It is of great significance to identify ADK
Xiang Li, Chengcheng Lyu, Jun Song, Yifei Lu, Fuchun Zeng, Liming Lu, Liqin Li   +6 more
doaj   +1 more source

Cyclic AMP metabolism and adenylate cyclase concentration in patients with advanced hepatic cirrhosis [PDF]

, 1978
Glucagon was tested for its effect on plasma adenosine 3′,5′-cyclic monophosphate (cyclic AMP), insulin, and glucose in healthy subjects and in patients with advanced cirrhosis of the liver. In the normal subjects, intravenous infusion of glucagon caused
Antonio Francavilla, Arthur F. Jones, Ball, Blonde, Bressler, Broadus, Broadus, Broadus, Brooker, Charles, Cherrington, Claycomb, Conn, Conn, Conn, Davies, Exton, Exton, Felig, Foa, Francavilla, Gilman, Hendy, Jerumo, Kaminsky, Kimmel, Krishna, Lambert, Lambert, Lambert, Levine, Liljenquist, Mackrell, Makman, Marco, McCullough, Milner, Miyamoto, Mori, Robison, Salomon, Sherwin, Srikant, Starzl, Strange, Strange, Sullivan, Sutherland, Taylor, Thomas E. Starzl, Turinsky, Turtle, Unger, Van Itallie, Vecchio, Verhaegen, Wahren, Walsh, White, Williams, Yalow, Zenser   +61 more
core   +1 more source

Rare hereditary nonspherocytic hemolytic anemia caused by a novel homozygous mutation, c.301C > A, (Q101K), in the AK1 gene in an Indian family

BMC Medical Genomics, 2021
Background Adenylate kinase (AK) deficiency is a rare red cell enzymopathy associated with moderate to severe congenital nonspherocytic hemolytic anemia, along with mental and psychomotor retardation (in exceptional cases).
Rashmi Dongerdiye, Abhilasha Sampagar, Rati Devendra, Prashant Warang, Prabhakar Kedar   +4 more
doaj   +1 more source

Functional modes of proteins are among the most robust ones [PDF]

, 2004
It is shown that a small subset of modes which are likely to be involved in protein functional motions of large amplitude can be determined by retaining the most robust normal modes obtained using different protein models.
A. Atilgan, B. R. Brooks, C. Chennubhotla, G. Li, K. Hinsen, M. Tirion, S. Nicolay, Y. Wu, Y.-H. Sanejouand   +8 more
core   +3 more sources

Energetics and Structural Characterization of the large-scale Functional Motion of Adenylate Kinase

Scientific Reports, 2015
Adenylate Kinase (AK) is a signal transducing protein that regulates cellular energy homeostasis balancing between different conformations. An alteration of its activity can lead to severe pathologies such as heart failure, cancer and neurodegenerative ...
Elena Formoso, V. Limongelli, M. Parrinello   +2 more
semanticscholar   +1 more source