Results 71 to 80 of about 76,182 (200)

Adenylate kinase hCINAP determines self-renewal of colorectal cancer stem cells by facilitating LDHA phosphorylation

Nature Communications, 2017
Targeting the specific metabolic phenotypes of colorectal cancer stem cells (CRCSCs) is a potential therapeutic strategy for colorectal cancer (CRC). Here, the authors show that adenylate kinase hCINAP is overexpressed in CRC, binds to the C-terminal ...
Yapeng Ji, Chuanzhen Yang, Zefang Tang, Yongfeng Yang, Yonglu Tian, Hongwei Yao, Xi Zhu, Zemin Zhang, Jiafu Ji, Xiaofeng Zheng   +9 more
doaj   +1 more source

Engineered Living Energy Materials

Interdisciplinary Materials, EarlyView.
Engineered living energy materials (ELEMs) are nascent research frontier for enabling sustainable energy conversion and storage. These materials exhibit unique characteristics such as self‐regeneration, biodegradability, environmental response, and evolutionary adaptability. This paper overviews different energy conversion bio‐modules, summarizes their
Xinyi Yuan, Haiyi Xu, Xingwu Liu, Jicong Zhang, Jing Li, Qianyi Liang, Bolin An, Giuseppe Maria Paternò, Minyue Zhang, Yuqing Tang, Chen Zhang, Dake Xu, Chao Zhong, Ke Li, Xinyu Wang   +14 more
wiley   +1 more source

Stable Isotope Tracing Uncovers Reduced γ/β-ATP Turnover and Metabolic Flux Through Mitochondrial-Linked Phosphotransfer Circuits in Aggressive Breast Cancer Cells

Frontiers in Oncology, 2022
Changes in dynamics of ATP γ- and β-phosphoryl turnover and metabolic flux through phosphotransfer pathways in cancer cells are still unknown. Using 18O phosphometabolite tagging technology, we have discovered phosphotransfer dynamics in three breast ...
Aleksandr Klepinin, Aleksandr Klepinin, Sten Miller, Sten Miller, Indrek Reile, Marju Puurand, Egle Rebane-Klemm, Egle Rebane-Klemm, Ljudmila Klepinina, Ljudmila Klepinina, Heiki Vija, Song Zhang, Andre Terzic, Andre Terzic, Petras Dzeja, Tuuli Kaambre   +15 more
doaj   +1 more source

Exploring the Role of T‐Cell Metabolism in Modulating Immunotherapy Efficacy for Non‐Small Cell Lung Cancer Based on Clustering

Journal of Clinical Laboratory Analysis, EarlyView.
We conducted a comprehensive investigation of the metabolic profiles of infiltrating T cells in NSCLC tumors and found metabolic heterogeneity in three T‐cell subtypes, which are associated with the prognosis of ICB therapy. We defined these metabolic clusters as response‐dependent (R) clusters and non‐response‐dependent (NR) clusters, and elucidated ...
Hongzhe Guo, Liangyu Zhang, Hu Tang, Peiwen Liu, Bin Hu, Yue Gong, Rui Hou, Ziheng Wu   +7 more
wiley   +1 more source

Inhibition of Streptococcus pneumoniae adenylate kinase by some 5-arylidene-thiazolidin-4-on-2-thione derivates

Romanian Journal of Laboratory Medicine, 2013
Adenilat kinaza este o enzimă ubiquitară prezentă atât la procariote cât şi la eucariote. în această lucrare am testat acţiunea inhibitorie a şase 5-ariliden-tiazolidin-4-on-2-tione faţă de adenilat kinaza din Strepto- coccus pneumoniae (A\Ksp) prin ...
Ionescu Miliaela Ileana, Costache Adriana Z., Oniga Ovidiu, Banciu Horia L., Lupan Iulia   +4 more
doaj   +1 more source

Time Course of the Increase in the Myocardial Slow Inward Current after a Photochemically Generated Concentration Jump of Intracellular cAMP [PDF]

, 1983
Voltage-clamped atrial trabeculae from bullfrog hearts were exposed to membrane-permeant photolyzable o-nitrobenzyl esters of cAMP and cGMP. UV flashes produced intracellular concentration jumps of cAMP or cGMP. With the cAMP derivative, flashes resulted
Engels, Joachim, Lester, Henry A., Nargeot, Joel, Nerbonne, Jeanne M.   +3 more
core   +1 more source

Photoaffinity labeling coupled to MS to identify peptide biological partners: Secondary reactions, for better or for worse?

Mass Spectrometry Reviews, EarlyView.
Abstract Affinity photolabeling is a smart method to study noncovalent and transient interactions and provide a submolecular picture of the contacts between interacting partners. In this review, we will focus on the identification of peptide partners using photoaffinity labeling coupled to mass spectrometry in different contexts such as in vitro with a
Astrid Walrant, Emmanuelle Sachon
wiley   +1 more source

Monoclonal antibodies to a membrane glycoprotein induce the phosphorylation of histone H1 in sea urchin spermatozoa. [PDF]

, 1988
Two groups of mAbs reacting with external domains of a major sea urchin sperm membrane glycoprotein of 210 kD were isolated. Previous studies have shown that group I mAbs inhibit the acrosome reaction induced by egg jelly and also cause large increases ...
Ebina, Y, Moy, GW, Porter, DC, Trimmer, JS, Vacquier, VD   +4 more
core  

Domain movement in rabbit muscle adenylate kinase might involve proline isomerization [PDF]

, 1997
The fluorescence probe, 8-anilino-1-naphthalenesulfonic acid (ANS), was used to monitor the induced-fit conformational movement in rabbit muscle adenylate kinase.
Li, X.F, Pan, X.M, Sheng, X.R, Zhang, H.J, Zhou, J.M   +4 more
core   +1 more source

Investigating the Mechanism of Conditioning Versus Postoperative Electrical Stimulation to Enhance Nerve Regeneration: One Therapy, Two Distinct Effects

Muscle &Nerve, EarlyView.
ABSTRACT Regeneration after peripheral nerve injury is often insufficient for functional recovery. Postoperative electrical stimulation (PES) following injury and repair significantly improves clinical outcomes; recently, conditioning electrical stimulation (CES), delivered before nerve injury, has been introduced as a candidate for clinical ...
Paige B. Hardy, Bonnie Y. Wang, K. Ming Chan, Christine A. Webber, Jenna‐Lynn B. Senger   +4 more
wiley   +1 more source