Results 81 to 90 of about 76,182 (200)

Optimization of ATP synthase function in mitochondria and chloroplasts via the adenylate kinase equilibrium

Frontiers in Plant Science, 2015
The bulk of ATP synthesis in plants is performed by ATP synthase, the main bioenergetics engine of cells, operating both in mitochondria and in chloroplasts.
Abir U Igamberdiev, Leszek A Kleczkowski
doaj   +1 more source

Machine Learning‐Based High‐Throughput Screening, Molecular Modeling and Quantum Chemical Analysis to Investigate Mycobacterium tuberculosis MetRS Inhibitors

ChemistryOpen, EarlyView.
This paper provides a comprehensive approach using the ChEMBL database to construct a machine learning model that screened 10 million compounds from the eMolecules database. Two promising inhibitors targeting Mycobacterium tuberculosis methionyl‐tRNA synthetase were identified.
Rajesh Maharjan, Kalpana Gyawali, Arjun Acharya, Madan Khanal, Kamal Khanal, Mohan Bahadur Kshetri, Madhav Prasad Ghimire, Tika Ram Lamichhane   +7 more
wiley   +1 more source

Multiscale coarse-graining of the protein energy landscape. [PDF]

PLoS Computational Biology, 2010
A variety of coarse-grained (CG) models exists for simulation of proteins. An outstanding problem is the construction of a CG model with physically accurate conformational energetics rivaling all-atom force fields.
Ronald D Hills, Lanyuan Lu, Gregory A Voth   +2 more
doaj   +1 more source

Cyclic AMP Receptor Protein from Yeast Mitochondria [PDF]

, 1985
We have identified and characterized a cyclic AMP receptor protein in mitochondria of the yeast Saccharomyces cerevisiae. The binding is specific for cyclic nucleotides, particularly for cyclic AMP which is bound with high affinity (Kd of 10(-9) M) at 1 ...
Bandlow, Wolfhard, Müller, Günter, Rödel, Gerhard   +2 more
core  

Organic Reactivity Matters for the Emergence of Life: Kinetic Barriers and Molecular Diversity Are Suggested as Crucial Factors by Emerging Autonomous System Models

ChemSystemsChem, EarlyView.
Self‐organisation may result from organic systems fed with free energy provided that reactivity becomes a determining factor. The propensity of carbon to form covalent bonds can give rise to kinetically stable thermodynamically activated compounds possibly undergoing non‐linear kinetic processes.
Robert Pascal
wiley   +1 more source

Anthrax edema toxin modulates PKA- and CREB-dependent signaling in two phases.

PLoS ONE, 2008
BackgroundAnthrax edema toxin (EdTx) is an adenylate cyclase which operates in the perinuclear region of host cells. However, the action of EdTx is poorly understood, especially at molecular level. The ability of EdTx to modulate cAMP-dependent signaling
Andrea Puhar, Federica Dal Molin, Stéphanie Horvath, Daniel Ladant, Cesare Montecucco   +4 more
doaj   +1 more source

Fabrication, characterisation and performance of hydrophilic and super-hydrophilic silica as cell culture surfaces [PDF]

, 2012
We demonstrate a straightforward procedure for the controlled formation of silica films on tissue culture polystyrene (PS) surfaces. The films were formed by sequentially treating PS with polyaniline, glutaric dialdehyde and protein prior to silica ...
Boocock, DJ, Hickman, GJ, Perry, CC, Rai, A, Rees, RC   +4 more
core   +1 more source

Cochlear Cell Atlas of Two Laryngeal Echolocating Bats—New Evidence for the Adaptive Nervous Physiology in Constant Frequency Bat

Molecular Ecology Resources, EarlyView.
ABSTRACT Bats have evolved highly adapted auditory mechanisms associated with ecological specialisation. However, there is scattered knowledge about the neurophysiological and cellular basis underlying high‐frequency hearing in echolocating bats. Herein, the total cochlear cell atlas of Rhinolophus ferrumequinum (constant frequency (CF) bat) and Myotis
Xue Wang, Mingyue Bao, Hui Wang, Ruyi Sun, Wentao Dai, Keping Sun, Yue Zhu, Yingting Pu, Yujia Chu, Xintong Li, Tianhui Wang, Minjie Zhang, Aiqing Lin, Jiqian Li, Jiang Feng   +14 more
wiley   +1 more source

The activity of cAMP-Phosphodiesterase 4D7 (PDE4D7) is regulated by protein kinase A-dependent phosphorylation within its unique N-terminus [PDF]

, 2015
The cyclic AMP phosphodiesterases type 4 (PDE4s) are expressed in a cell specific manner, with intracellular targeting directed by unique N-terminal anchor domains.
Ashleigh M. Byrne, Baillie, Brown, Carlisle Michel, Christina Elliott, Flacke, Francis, George S. Baillie, Gretarsdottir, Gutierrez-Canas, Henderson, Houslay, Houslay, Huston, Kasbohm, Kashiwagi, Kvissel, Lee, Li, Li, MacKenzie, Merkle, Perino, Ralf Hoffmann, Sin   +24 more
core   +1 more source

Reversal of age-related learning deficiency by the vertebrate PACAP and IGF-1 in a novel invertebrate model of aging: the pond snail (Lymnaea Stagnalis) [PDF]

, 2014
With the increase of life span, nonpathological age-related memory decline is affecting an increasing number of people. However, there is evidence that age-associated memory impairment only suspends, rather than irreversibly extinguishes, the intrinsic ...
Alexander, Audesirk, Chaudhury, D. Regl di, Delcourt, Du, G. Kemenes, Hattiangady, Hermann, Hernadi, I. Kemenes, J  zsa, Kemenes, Kemenes, Lee, Markowska, Otto, Otto, Patel, Patel, Pavlopoulos, Pirger, Pirger, Pirger, Roberto, S. Naskar, Sacchetti, Shioda, Silhol, Tamas, Telegdy, Vaudry, Watson, Watson, Yang, Yeoman, Z. Laszlo, Z. Pirger, Zhang   +38 more
core   +2 more sources