Results 91 to 100 of about 1,622 (220)

P-glycoprotein inhibition using valspodar (PSC-833) does not improve outcomes for patients younger than age 60 years with newly diagnosed acute myeloid leukemia: Cancer and Leukemia Group B study 19808

, 2010
Cancer and Leukemia Group B 19808 (CALGB 19808) is the only randomized trial of a second-generation P-glycoprotein (Pgp) modulator in untreated patients with acute myeloid leukemia (AML) younger than age 60 years.
Stephen L. George, Clara D. Bloomfield, Thomas C. Shea, Daniel J. DeAngelo, Maria R. Baer, Ravi Vij, Kati Maharry, James W. Vardiman, Eva Hoke, Jonathan E. Kolitz, Wendy Stock, Richard A. Larson, null null, Guido Marcucci, Steven L. Allen, Bayard L. Powell, Vera Hars   +16 more
core   +1 more source

Acyldepsipeptide analogs dysregulate human mitochondrial ClpP protease activity and cause apoptotic cell death

, 2018
Acyldepsipeptides (ADEPs) are potential antibiotics that dysregulate the activity of the highly conserved tetradecameric bacterial ClpP protease, leading to bacterial cell death. Here, we identified ADEP analogs that are potent dysregulators of the human
Wong, Keith S, Mennella, Vito, Babu, Mohan, Batey, Robert A, Houry, Walid A, Mabanglo, Mark F, Seraphim, Thiago V, Mao, Yu-Qian, Phanse, Sadhna, Leung, Elisa, Schimmer, Aaron D, Barbosa, Leandro R S, Mollica, Antonio, Moutaoufik, Mohamed T, Goodreid, Jordan, Ramos, Carlos H I, Rizzolo, Kamran, Hoell, Larissa   +17 more
core   +1 more source

Determinants of fibrinogen in an Italian population suffering from claudication. Lower fibrinogen in the south compared to middle and north of Italy. The ADEP Group

Haematologica, 1998
BACKGROUND AND OBJECTIVE: Prospective studies have shown that high plasma levels of fibrinogen are independently associated with the risk of cardiovascular complications.
S Basili, M Milani, A Longoni, M Vieri, L Iuliano, F Violi   +5 more
doaj  

Cost-based optimizations of power density and target-blanket modularity for {sup 232}Th/{sup 233}U-based ADEP

, 1995
A cost-based parametric systems model is developed for an Accelerator-Driven Energy Production (ADEP) system based on a {sup 232}Th/{sup 233}U fuel cycle and a molten-salt (LiF/BeF{sub 2}/ThF{sub 3}) fluid-fuel primary system. Simplified neutron-balance,
Krakowski, Robert A.
core  

30 ans après que veut le peuple ... : la démocratie ou la dictature éclairée?

, 2022
Friedrich-Ebert-Stiftung, adep, Association des Dessinateurs de Presse; préfacé par Mr Manuel Wollschläger, directeur pays de Friedrich-Ebert-Stiftung ; Texte: Adrien Vanda et Philippe ...

core  

AAA+ chaperones and acyldepsipeptides activate the ClpP protease via conformational control.

, 2015
The Clp protease complex degrades a multitude of substrates, which are engaged by a AAA+ chaperone such as ClpX and subsequently digested by the dynamic, barrel-shaped ClpP protease.
Sieber, S.A., Famulla, K., Korotkov, V.S., Sass, P., Richter, K., Gersch, M., Brötz-Oesterhelt, H., Göbl, C., Rübsamen-Schaeff, H., Madl, T., Dahmen, M., Malik, I.   +11 more
core   +1 more source

Antibiotic acyldepsipeptides activate ClpP peptidase to degrade the cell division protein FtsZ

, 2011
The worldwide spread of antibiotic-resistant bacteria has lent urgency to the search for antibiotics with new modes of action that are devoid of preexisting cross-resistances.
Peter Sass, Heike Brötz-Oesterhelt, Kirsten Famulla, Michaele Josten, Leendert Hamoen, Hans-Georg Sahl, Guido Schiffer   +6 more
core   +1 more source

Investigation of the effects of quercetin on the structure and properties of zinc-modified hydroxyapatites

In this study, hydroxyapatite (HAp) samples, co-doped with 0.44 at.% of zinc and different amount of quercetin (Zn/Que-HAp), were synthesised using a wet-chemical method and calcined at 900 degrees C.
Mahmood, Bahroz Kareem, Kaya, Semih, Bulut, Niyazi, Barzinjy, Azeez A., Kareem, Rebaz Obaid, Temuz, Mehmet Mursit, Keser, Serhat   +6 more
core   +1 more source

ADEP - Ambiente Digital das Escolas Públicas

Projeto de um ambiente digital para escolas públicas do estado de São Paulo.  Com o objetivo de facilitar a organização pessoal e institucional dentro das escolas.
Gebin Souza de Almeida, Luan, Oliveira, Raquel Oliveira Ferreira, Aparecida, Juliana da Silva Oliveira, Jesus, Daniela Vicente   +3 more
openaire   +1 more source

Synthesis and Characterization of CeO2 samples doped with Bi

FF.24.03 ve ADEP.24.09[Abstract Not Available]The Management Unit of Scientific Research Projects of Firat University (FUBAP), COST ...
Bulut, Niyazi, Kaygılı, Omer, Ateş, Tankut, Keser, Serhat   +3 more
core   +1 more source