Results 151 to 160 of about 41,061 (259)

Activation parameters, enthalpy–entropy compensation and the temperature‐dependent activity of enzymes

open access: yesProtein Science, Volume 35, Issue 8, August 2026.
Abstract The increase in enzyme‐catalyzed reaction rates with temperature is typically modeled using Arrhenius or Eyring relations. Interpretation of extracted parameters is subject to multiple caveats. Here we analyze the impact of temperature variations of underlying activation or Eyring parameters and of temperature‐dependent contributions to ...
Matthew J. McLeod, Robert E. Thorne
wiley   +1 more source

DNA‐Enzyme Hybrid Nanostructures: Functional Materials to Modulate Enzymatic Activity

open access: yesSmall, Volume 22, Issue 43, 3 August 2026.
DNA–enzyme hybrid nanostructures enable precise spatial and stoichiometric control over enzyme organization, offering a powerful platform to modulate catalytic activity. This review critically evaluates key mechanistic hypotheses, including proximity effects, microenvironment changes, confinement, and stabilization, as well as highlighting ...
Manar Elnaggar, Amelie Heuer‐Jungemann
wiley   +1 more source

From prediction to intervention: Paradigm shifts in causal AI for precision medicine and large‐scale cohorts

open access: yesVIEW, Volume 7, Issue 4, August 2026.
Large‐scale cohorts and multimodal biomedical data have enabled powerful predictive models for clinical risk stratification, but prediction alone cannot guide effective interventions. This review introduces causal artificial intelligence as a design‐first framework that integrates target trial emulation, causal discovery, and robust effect estimation ...
Linlin Cao   +5 more
wiley   +1 more source

Pituitary apoplexy presenting as refractory hyponatremia. [PDF]

open access: yesJCEM Case Rep
Chandra S   +4 more
europepmc   +1 more source

Maternal glucocorticoids have persistent effects on offspring social phenotype irrespective of opportunity for social buffering

open access: yesJournal of Animal Ecology, Volume 95, Issue 8, Page 1326-1338, August 2026.
This study tests whether early‐life maternal association buffers offspring from the effects of prenatal stress in a facultatively social lizard. Despite clear effects of maternal glucocorticoids on growth and social behaviour, social associations did not mitigate these effects, revealing limits to social buffering in this species.
Kirsty J. MacLeod   +4 more
wiley   +1 more source

Dexamethasone Versus Placebo in Comatose Survivors of Out‐of‐Hospital Cardiac Arrest: Study Protocol for a Multicenter Randomized Comparison Within the Danish Out‐of‐Hospital Cardiac Arrest Trial (DANOHCA)

open access: yesActa Anaesthesiologica Scandinavica, Volume 70, Issue 7, August 2026.
ABSTRACT Background The inflammatory response to whole‐body ischemia, as seen in comatose survivors after out‐of‐hospital cardiac arrest (OHCA), is associated with increased morbidity and mortality. Early high‐dose dexamethasone may dampen the inflammatory response, which may diminish secondary brain damage and other organ injury and decrease mortality.
Jo B. Andreasen   +12 more
wiley   +1 more source

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