Results 161 to 170 of about 53,020 (288)

Empirical Meropenem Versus Piperacillin/Tazobactam for Critically Ill Adults With Sepsis: Feasibility of a Randomised Trial

Acta Anaesthesiologica Scandinavica, Volume 70, Issue 9, October 2026.
ABSTRACT Background Meropenem and piperacillin/tazobactam are commonly used empirical antibiotics in critically ill adults with sepsis, but whether one is superior to the other is uncertain. Methods The Empirical Meropenem versus Piperacillin/Tazobactam for Adult Patients with Sepsis (EMPRESS) trial is an ongoing investigator‐initiated, randomised ...
Nick Frørup Meier, Morten Hylander Møller, Maj‐Brit Nørregaard Kjær, Fredrik Sjövall, Marie Warrer Munch, Benjamin Skov Kaas‐Hansen, Hans‐Christian Thorsen‐Meyer, Bodil Steen Rasmussen, Marie Helleberg, Frederik Boëtius Hertz, Theis Lange, Aksel Karl Georg Jensen, Lars Wiuff Andersen, Jakob Steen Andersen, Jens Michelsen, Lars Peter Kloster Andersen, Morten Heiberg Bestle, Anne Craveiro Brøchner, Theis Skovsgaard Itenov, Steffen Christensen, Ronni Thermann Reitz Plovsing, Klaus Ulrik Koch, Anders Møller, Olav Lilleholt Schjørring, Naia Bech Cranø, Kasper Vamdrup‐Andersen, Davide Placido, Tine Sylvest Meyhoff, Carl Thomas Anthon, Aske Tøgern, Milda Grigonyte‐Daraskeviciene, Zemira Engbakken, Anne Witte Kamstrup, Kis Rønn Uhre, Jehad Ahmad Barakji, Rikke Faebo Larsen, Anders Perner, Anders Granholm   +37 more
wiley   +1 more source

Crack-localization in elastomeric self-healing enabled by one supermolecule-analogous molecule. [PDF]

Nat Commun
Wang X, Han S, Luo S, Li Q, Li J, Li W, Gan L, Huang J.   +7 more
europepmc   +1 more source

The importance of cross‐talk in research and the body: An early career researcher perspective

Experimental Physiology, EarlyView.
Lucy J. Ryan, Jamie A. Elliott, Robert Little, Mhairi A. Paul   +3 more
wiley   +1 more source

Serum Copeptin Rises After Tolvaptan for Hyponatraemia, but Does Not Predict Risk of Rapid Sodium Rise: Pre‐Specified Secondary Analysis of the TVFR Trial

Clinical Endocrinology, Volume 105, Issue 4, Page 514-518, October 2026.
ABSTRACT Objective Hyponatraemia is a common electrolyte disorder often driven by excess arginine vasopressin (AVP). Copeptin is a stable surrogate marker co‐secreted with AVP. It is unclear whether treatment of hyponatraemia with tolvaptan, an AVP‐V2 receptor antagonist, impacts copeptin.
Annabelle M. Warren, Kay Weng Choy, Rudolf Hoermann, Nicholas Russell, Mathis Grossmann   +4 more
wiley   +1 more source

Whole-Cell Fungal Biotransformation of <i>para</i>-Hydroxycinnamic Acids Mediated by Phenolic Acid Decarboxylase, Carboxylic Acid Reductase and Alcohol Dehydrogenase. [PDF]

Molecules
Baskaran A, Serra S, El-Sayed ER, Tronina T, Łyczko J, Olejniczak T, Brenna E, Boratyński F.   +7 more
europepmc   +1 more source

IMPROVE 2025: The 3rd International Meeting on Pathway‐Related Obesity: Vision & Evidence

Clinical Obesity, Volume 16, Issue 5, October 2026.
ABSTRACT An international cohort of 161 clinicians and researchers from 19 countries attended the 3rd International Meeting on Pathway‐Related Obesity: Vision & Evidence (IMPROVE) in Prague, Czech Republic, on 2–4 July 2025. The aims of the meeting were to advance understanding of hyperphagia and obesity caused by defects in the melanocortin‐4 receptor
Jesús Argente, Erica L. T. van den Akker, Metin Cetiner, Karine Clément, Elizabeth Forsythe, Alastair Garfield, Peter Kühnen, Gabriel Ángel Martos‐Moreno, David Meeker, Hermann L. Müller, Hanneke M. van Santen, Julia von Schnurbein, Bérénice Segrestin, Tomohiro Tanaka, Manuel Tena‐Sempere, Martin Wabitsch, Stefanie Zorn, I. Sadaf Farooqi   +17 more
wiley   +1 more source

Mechanosensitive TRPV4 immunohistochemistry improves deep learning-based classification of ductal carcinoma in situ beyond H&E morphology. [PDF]

J Pathol Clin Res
Yoo J, Karthikeyan R, Kamat K, Chan C, Samankan S, Arbzadeh E, Schwartz A, Latham PS, Chung I.   +8 more
europepmc   +1 more source

An Integrated Analysis of Manganese Metabolism‐Related Genes and Their Association With Biomarkers, Immune Infiltration, and Clinical Subtypes in Alzheimer's Disease

Genes, Brain and Behavior, Volume 25, Issue 5, October 2026.
This study investigates the role of manganese metabolism in Alzheimer's disease (AD) pathogenesis. Using integrated bioinformatics and machine learning, four core manganese‐related diagnostic genes (TSPO, PTBP1, GLO1, ACACB) were identified, showing high diagnostic accuracy. The analysis also revealed significant immune microenvironment alterations and
Shengnan Shu, Jiahao Hu, Shanshan Hu, Yefeng Yao   +3 more
wiley   +1 more source

Employing AC and DC Electrolysis to Modulate Electroenzymatic Pathways for Efficient and Stereoselective H-D Exchange. [PDF]

J Am Chem Soc
El Housseini W, Gerulskis R, Behera N, Guan H, Jadhav RG, Nguyen ZA, Baiarashov E, Pence MA, Kamaja VK, Larkin T, Luo L, Minteer SD.   +11 more
europepmc   +1 more source

Liver cirrhosis is associated with altered glucocorticoid metabolism related to disease severity

Journal of Internal Medicine, Volume 300, Issue 4, Page 513-527, October 2026.
Abstract Background Liver cirrhosis (LC) is frequently complicated by adrenal dysfunction; however, whether cirrhosis drives the coordinated, pathway‐specific reprogramming of cortisol metabolism remains unclear. Objectives We aimed to characterize axis‐specific alterations in cortisol metabolism in patients with LC, those with adrenal insufficiency ...
Soyeon Park, Min Jeong Park, Hye Won Yang, Jeayeon Park, Su Jong Yu, Seung Shin Park, Man‐Ho Choi, Eun Ju Cho, Jung Hee Kim   +8 more
wiley   +1 more source