Results 31 to 40 of about 41,061 (259)

Preparation and properties of Pue-loaded HA-ADH-PS nanomicelles

open access: yesDesigned Monomers and Polymers, 2021
Puerarin (Pue) is the most abundant isoflavonoid in kudzu root. It has been widely used as a therapeutic agent for the treatment of cardiovascular diseases.
Huiru Wang   +7 more
doaj   +1 more source

Wineries, drosophila, alcohol, and Adh [PDF]

open access: yesOecologia, 1980
Uploaded by Plazi for TaxoDros. We do not have abstracts.
Marks, R William   +4 more
openaire   +5 more sources

Bioadhesive Hydrogel With Polyphenol‐Armored Nanogene Rejuvenates Chondrocyte Senescence for Aged Osteoarthritis Therapy

open access: yesAdvanced Science, EarlyView.
An adhesive hydrogel depot with polyphenol‐armored nanogenes is developed for treating aged osteoarthritis. This system maintains miR‐140 bioactivity, prolongs its intra‐articular retention, and enhances transfection into chondrocytes, leading to the downregulation of senescence‐associated pathways.
Liwei Yan   +10 more
wiley   +1 more source

A Cholesterol Analogue for Cell‐Surface Enzyme Display

open access: yesAngewandte Chemie, EarlyView.
We report a non‐genetic strategy for bacterial cell surface enzyme immobilisation using cholesterol‐based artificial lipids containing Ni2+‐NTA binding groups that can integrate into biological membranes. The engineered cells can capture His‐tagged enzymes directly from cell lysates while preserving intracellular and surface activity, allowing for ...
Vasco F. Batista   +3 more
wiley   +2 more sources

Linking Dysregulated AMPK Signaling and ER Stress in Ethanol-Induced Liver Injury in Hepatic Alcohol Dehydrogenase Deficient Deer Mice

open access: yesBiomolecules, 2019
Ethanol (EtOH) metabolism itself can be a predisposing factor for initiation of alcoholic liver disease (ALD). Therefore, a dose dependent study to evaluate liver injury was conducted in hepatic alcohol dehydrogenase (ADH) deficient (ADH−) and ADH normal
Mukund P. Srinivasan   +6 more
doaj   +1 more source

ADH IB expression, but not ADH III, is decreased in human lung cancer. [PDF]

open access: yesPLoS ONE, 2012
Endogenous S-nitrosothiols, including S-nitrosoglutathione (GSNO), mediate nitric oxide (NO)-based signaling, inflammatory responses, and smooth muscle function.
Sarah C Mutka   +6 more
doaj   +1 more source

Activity of Total Alcohol Dehydrogenase, Alcohol Dehydrogenase Isoenzymes and Aldehyde Dehydrogenase in the Serum of Patients with Alcoholic Fatty Liver Disease

open access: yesMedicina, 2021
Background and objectives: The aim of the current study was to assess the use of determinations of total alcohol dehydrogenase and the activity of its isoenzymes as well as aldehyde dehydrogenase in the serum of patients with alcohol liver disease ...
Blanka Wolszczak-Biedrzycka   +5 more
doaj   +1 more source

Palatable‐Food–Driven Top‐Down Circuit Inhibits PVNCRF Activity to Mitigate Stress Via Peri‐PVNCRFR1 Neurons

open access: yesAdvanced Science, EarlyView.
Palatable food alleviates stress and prevents anxiety. This study uncovers a dedicated neural pathway: dopamine release in the PFC activates D1R neurons, whose projections to the peri‐PVN engage a population of anxiolytic CRFR1 neurons. These neurons then inhibit stress‐induced hyperactivity of PVNCRF neurons, providing a circuit‐level explanation for ...
Yuchuan Hong   +12 more
wiley   +1 more source

Developing syndrome of inappropriate antidiuretic hormone secretion in Guillain-Barre syndrome

open access: yesOpen Health
Guillain-Barre Syndrome (GBS) is associated with weakness of limbs along with pain and numbness of the affected limbs. There may develop other features in GBS patients as well, especially in those who are ventilated, such as paralysis of respiratory and ...
Tajwar Sakib
doaj   +1 more source

酶解法制备火麻仁乙醇脱氢酶激活肽的工艺研究Preparation of hemp seed alcohol dehydrogenase-activating peptides by enzymolysis

open access: yesZhongguo youzhi
为高值化开发火麻仁蛋白,以火麻仁蛋白为原料,采用蛋白酶对其酶解制备火麻仁乙醇脱氢酶(ADH)激活肽,以ADH激活率为评价指标,筛选出最佳的蛋白酶,在此基础上,采用单因素实验和响应面实验优化火麻仁ADH激活肽的制备工艺。测定了火麻仁ADH激活肽的分子质量分布和氨基酸组成,并通过扫描电子显微镜对其微观结构进行分析。结果表明:采用中性蛋白酶酶解得到的火麻仁ADH激活肽对ADH的激活率最高,更适于火麻仁蛋白的酶解;火麻仁ADH激活肽的最佳制备工艺为酶解温度44 ℃、酶解时间2.75 h、pH 6.2、酶添加量3.
魏连会,温维浩,葛婧仪,董艳 WEI Lianhui, WEN Weihao, GE Jingyi, DONG Yan
doaj   +1 more source

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