Results 101 to 110 of about 381,964 (386)

Autophagy in cancer and protein conformational disorders

open access: yesFEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

ADHD AND AUTISM SPECTRUM DISORDER IN EARLY CHILDHOOD [PDF]

open access: yesRomanian Journal of Pediatrics, 2008
In recent years, currently, we come to grip with „aflutter little child“ which, forth somatic disorders, present also hyperactivity, inattention, and social interaction deficits and communication disorders.
Florina Rad   +2 more
doaj   +1 more source

Protonophore activity of short‐chain fatty acids induces their intracellular accumulation and acidification

open access: yesFEBS Letters, EarlyView.
The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang   +2 more
wiley   +1 more source

Can the Child Behavior Checklist (CBCL) help characterize the types of psychopathologic conditions driving child psychiatry referrals? [PDF]

open access: yesScandinavian Journal of Child and Adolescent Psychiatry and Psychology, 2020
Joseph Biederman   +7 more
doaj   +1 more source

Attention deficit hyperactivity symptoms predict problematic mobile phone use [PDF]

open access: yes, 2020
Attention-deficit-hyperactivity disorder (ADHD) is the most commonly diagnosed childhood disorder characterised by inattention, hyperactivity/impulsivity, or both.
A Bianchi   +52 more
core   +3 more sources

A stepwise emergence of evolution in the RNA world

open access: yesFEBS Letters, EarlyView.
How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley   +1 more source

Association Between ADHD and Obesity: A Systematic Review and Meta-Analysis.

open access: yesAmerican Journal of Psychiatry, 2015
OBJECTIVE Impulsivity and inattention related to attention deficit hyperactivity disorder (ADHD) may increase food intake and, consequently, weight gain. However, findings on the association between obesity/overweight and ADHD are mixed.
S. Cortese   +5 more
semanticscholar   +1 more source

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

open access: yesFEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp   +5 more
wiley   +1 more source

Further evidence of the Diagnostic Utility of the Child Behavior Checklist for identifying pediatric Bipolar I Disorder [PDF]

open access: yesScandinavian Journal of Child and Adolescent Psychiatry and Psychology, 2019
Amy Yule   +8 more
doaj   +1 more source

The familial co-aggregation of ASD and ADHD: a register-based cohort study

open access: yesMolecular Psychiatry, 2017
Autism spectrum disorders (ASD) and attention-deficit/hyperactivity disorder (ADHD) frequently co-occur. The presence of a genetic link between ASD and ADHD symptoms is supported by twin studies, but the genetic overlap between clinically ascertained ASD
L. Ghirardi   +8 more
semanticscholar   +1 more source

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