Results 101 to 110 of about 385,423 (386)

Is Adult ADHD a Childhood-Onset Neurodevelopmental Disorder? Evidence From a Four-Decade Longitudinal Cohort Study.

American Journal of Psychiatry, 2015
OBJECTIVE Despite a prevailing assumption that adult ADHD is a childhood-onset neurodevelopmental disorder, no prospective longitudinal study has described the childhoods of the adult ADHD population. The authors report follow-back analyses of ADHD cases
T. Moffitt, R. Houts, P. Asherson, Daniel W Belsky, D. Corcoran, Maggie Hammerle, H. Harrington, Sean Hogan, M. Meier, G. Polanczyk, R. Poulton, S. Ramrakha, K. Sugden, Benjamin S. Williams, L. Rohde, A. Caspi   +15 more
semanticscholar   +1 more source

Personality traits in adults with attention-deficit hyperactivity disorder and their unaffected first-degree relatives

BJPsych Open, 2016
Background Attention-deficit hyperactivity disorder (ADHD) shows clear, albeit heterogeneous, cognitive dysfunctions.
Valentino Antonio Pironti, Meng-Chuan Lai, Ulrich Müller, Edward Thomas Bullmore, Barbara Jacquelyn Sahakian   +4 more
doaj   +1 more source

Social Difficulties in Youth with Autism With and Without Anxiety and ADHD Symptoms [PDF]

, 2018
Social difficulties inherent to autism spectrum disorder are often linked with co‐occurring symptoms of anxiety and attention deficit hyperactivity disorder (ADHD).
Carlson, Mary E., Casnar, Christina L., Dolan, Bridget Kathleen, Haendel, Angela D., Karst, Jeffrey S., Krueger, Wendy, McVey, Alana J., Murphy, Christina C., Pleiss, Sheryl, Schiltz, Hillary, Van Hecke, Amy V., Willar, Kirsten S., Yund, Brianna D.   +12 more
core   +2 more sources

The neurobiological basis of ADHD [PDF]

Italian Journal of Pediatrics, 2010
Attention-Deficit/Hyperactivity Disorder is not a single pathophysiological entity and appears to have a complex etiology. There are multiple genetic and environmental risk factors with small individual effect that act in concert to create a spectrum of neurobiological liability.
CURATOLO, PAOLO, D'Agati, E, MOAVERO, ROMINA   +2 more
openaire   +5 more sources

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

Discovery of the first genome-wide significant risk loci for ADHD

bioRxiv, 2017
Attention-Deficit/Hyperactivity Disorder (ADHD) is a highly heritable childhood behavioral disorder affecting 5% of school-age children and 2.5% of adults.
D. Demontis, R. Walters, Joanna Martin, M. Mattheisen, T. Als, E. Agerbo, R. Belliveau, J. Bybjerg-Grauholm, Marie Bækvad-Hansen, Felecia Cerrato, K. Chambert, C. Churchhouse, Ashley L. Dumont, N. Eriksson, M. Gandal, J. Goldstein, J. Grove, C. Hansen, M. Hauberg, M. Hollegaard, D. Howrigan, Hailiang Huang, J. Maller, Alicia R. Martin, J. Moran, Jonatan Pallesen, D. Palmer, C. Pedersen, M. Pedersen, T. Poterba, J. Poulsen, S. Ripke, E. Robinson, Kyle F. Satterstrom, C. Stevens, P. Turley, H. Won, O. Andreassen, C. Burton, D. Boomsma, B. Cormand, S. Dalsgaard, B. Franke, J. Gelernter, D. Geschwind, H. Hakonarson, J. Haavik, H. Kranzler, J. Kuntsi, K. Langley, K. Lesch, C. Middeldorp, A. Reif, L. Rohde, P. Roussos, R. Schachar, P. Sklar, E. Sonuga-Barke, P. Sullivan, A. Thapar, J. Tung, I. Waldman, M. Nordentoft, D. Hougaard, T. Werge, O. Mors, P. Mortensen, M. Daly, S. Faraone, A. Børglum, B. Neale   +70 more
semanticscholar   +1 more source

Effect of methylphenidate treatment during adolescence on norepinephrine transporter function in orbitofrontal cortex in a rat model of attention deficit hyperactivity disorder [PDF]

, 2010
Attention deficit hyperactivity disorder (ADHD) is associated with hypofunctional medial prefrontal cortex (mPFC) and orbitofrontal cortex (OFC). Methylphenidate (MPH) remediates ADHD, in part, by inhibiting the norepinephrine transporter (NET). MPH also
Somkuwar, Sucharita S., Kantak, Kathleen M., Dwoskin, Linda P.   +2 more
core   +4 more sources

Adolescent D-amphetamine treatment in a rodent model of ADHD: pro-cognitive effects during adolescence and cocaine abuse risk during adulthood [PDF]

, 2015
Attention-deficit/hyperactivity disorder (ADHD) is comorbid with cocaine abuse. Whereas initiating ADHD medication in childhood does not alter later cocaine abuse risk, initiating medication during adolescence may increase risk.
Baskin, Britahny M., Dwoskin, Linda P., Jeon, Sae-Mi, Jordan, Chloe J., Kantak, Kathleen M., Taylor, Danielle M.   +5 more
core   +1 more source

The thioredoxin‐like and one glutaredoxin domain are required to rescue the iron‐starvation phenotype of HeLa GLRX3 knock out cells

FEBS Letters, EarlyView.
Glutaredoxin (Grx) 3 proteins contain a thioredoxin domain and one to three class II Grx domains. These proteins play a crucial role in iron homeostasis in eukaryotic cells. In human Grx3, at least one of the two Grx domains, together with the thioredoxin domain, is essential for its function in iron metabolism.
Laura Magdalena Jordt, Manuela Gellert, Finja Zelms, Sander Bekeschus, Christopher Horst Lillig   +4 more
wiley   +1 more source

Lack of kinase-independent activity of PI3Kγ in locus coeruleus induces ADHD symptoms through increased CREB signaling. [PDF]

, 2015
Although PI3Kγ has been extensively investigated in inflammatory and cardiovascular diseases, the exploration of its functions in the brain is just at dawning.
Alessandra Ghigo, Angelo Maffei, Daniela Carnevale, Emilio Hirsch, Fabio Pallante, Franklin KBJ, Giuseppe Lembo, Ivana D'Andrea, Roberta Iacobucci, Stefania Fardella, Valentina Fardella   +10 more
core   +1 more source