Results 231 to 240 of about 295,250 (283)

Insights into a long life without cancer: The case of the bowhead whale

open access: yesMolecular Oncology, EarlyView.
Long‐lived, large‐bodied organisms have evolved powerful anticancer mechanisms that preserve cellular and tissue integrity across extended lifespans. A recent study by Firsanov et al. shows that greater genome stability is a key factor underlying the remarkable longevity and cancer resistance of one such species, the bowhead whale.
Inés Paniagua, Johanna A. Joyce
wiley   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata   +10 more
wiley   +1 more source

Molecular cancer prevention: Intercepting disease

open access: yesMolecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco   +2 more
wiley   +1 more source

DSM-5 Changes, COVID-19, and ADHD Diagnosis Rates in Individuals Younger Than 30 Years.

open access: yesJAMA Netw Open
Cui Z   +5 more
europepmc   +1 more source

Measuring Accuracy (Classification Probabilities, Positive, and Negative Predictive Values) of Executive Function Electroencephalogram Metrics in Attention-Deficit/Hyperactivity Disorder Diagnosis: Protocol for and Perspectives From the SINCRONIA Study.

open access: yesJMIR Res Protoc
Blasco-Fontecilla H   +12 more
europepmc   +1 more source

Examination of Peer Interactions During Cooperative and Competitive Board Games Among Children with Attention-Deficit/Hyperactivity Disorder on and off Methylphenidate. [PDF]

open access: yesRes Child Adolesc Psychopathol
Jusko ML   +8 more
europepmc   +1 more source

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